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The map label for this gene is thrB [H]

Identifier: 124027694

GI number: 124027694

Start: 810158

End: 810832

Strand: Reverse

Name: thrB [H]

Synonym: Hbut_0816

Alternate gene names: 124027694

Gene position: 810832-810158 (Counterclockwise)

Preceding gene: 124027695

Following gene: 124027693

Centisome position: 48.64

GC content: 52.59

Gene sequence:

>675_bases
ATGGGTCTCGGGAGTAGTGGTGCTACAGCGGCAGCCACGGTGTACGCTATCAACGCGCTCCTTGGTAGTCCTCTCGAGCC
GATAGAGCTAGTACGATTTGCTGGCCTTGCTGAGGCGCTGACAGCGGGTGCACCACACTACGATAACGTTGCTGCCAGCC
TACTGGGTGGTTTGGTCATTCTGCTAAACCGTAAAAAACCGAGAATAGCACGGCTAAGACTACCGCCAGGCATGAGAATA
GTCCTCTTTATCCCGAAGACAATGGTGTTAAGACTGTTGCCTGGAAAGGCTAAAACACAAGTTATGAGGGAGGTTCTCCC
AGAAACTATAGAGCACAGCGATGCAGTTGAATGGGTAGAAAAGGCGGTTGCATTAGCCCTCGGCCTCAGCGGTGCAGATC
CATACGAAGCAATAAAGACAATAAATTATGGAGGTCCAATTGAGGCGACACGGGCAAAGCTGATTCCAGGCTATTGGGAA
GCCAAGAAGGAGGCTCTCCAGTCAGGCGCGCTAGCATTCAACATAAGCGGCGCAGGACCAACCCTCTTCGCAGTTGTAAG
GGAGGGTGAGGAGGACCAGGTTATGAGAAGGGTCTCAGCCGTGCTAGAGAAGTATTGGGGGTCTCTGGAGGCTAGAGTCG
TAGACGTGGACTATGATGGTGCAAGGCTGGAATAG

Upstream 100 bases:

>100_bases
GTGAGTCTAACACGGCATACGTGGCAGCCCGCAAACTGCTAGAGTATCTAGATGAGAAGCTTCATGTACGTATACTGTTG
AGAAGGGCATACCGCCCGGC

Downstream 100 bases:

>100_bases
GGTGTCGGACCAACTAACCGTCTACACAAACGGTGATCACTTACTCGAAGCCCACAAGGCTGGTGGCCTCGAGGTAGATG
ATGCAGGTTTAGTCCTCGTC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MGLGSSGATAAATVYAINALLGSPLEPIELVRFAGLAEALTAGAPHYDNVAASLLGGLVILLNRKKPRIARLRLPPGMRI
VLFIPKTMVLRLLPGKAKTQVMREVLPETIEHSDAVEWVEKAVALALGLSGADPYEAIKTINYGGPIEATRAKLIPGYWE
AKKEALQSGALAFNISGAGPTLFAVVREGEEDQVMRRVSAVLEKYWGSLEARVVDVDYDGARLE

Sequences:

>Translated_224_residues
MGLGSSGATAAATVYAINALLGSPLEPIELVRFAGLAEALTAGAPHYDNVAASLLGGLVILLNRKKPRIARLRLPPGMRI
VLFIPKTMVLRLLPGKAKTQVMREVLPETIEHSDAVEWVEKAVALALGLSGADPYEAIKTINYGGPIEATRAKLIPGYWE
AKKEALQSGALAFNISGAGPTLFAVVREGEEDQVMRRVSAVLEKYWGSLEARVVDVDYDGARLE
>Mature_223_residues
GLGSSGATAAATVYAINALLGSPLEPIELVRFAGLAEALTAGAPHYDNVAASLLGGLVILLNRKKPRIARLRLPPGMRIV
LFIPKTMVLRLLPGKAKTQVMREVLPETIEHSDAVEWVEKAVALALGLSGADPYEAIKTINYGGPIEATRAKLIPGYWEA
KKEALQSGALAFNISGAGPTLFAVVREGEEDQVMRRVSAVLEKYWGSLEARVVDVDYDGARLE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=226, Percent_Identity=30.0884955752212, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 23958; Mature: 23827

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGSSGATAAATVYAINALLGSPLEPIELVRFAGLAEALTAGAPHYDNVAASLLGGLVI
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEE
LLNRKKPRIARLRLPPGMRIVLFIPKTMVLRLLPGKAKTQVMREVLPETIEHSDAVEWVE
EEECCCCCEEEEECCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHH
KAVALALGLSGADPYEAIKTINYGGPIEATRAKLIPGYWEAKKEALQSGALAFNISGAGP
HHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCC
TLFAVVREGEEDQVMRRVSAVLEKYWGSLEARVVDVDYDGARLE
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
GLGSSGATAAATVYAINALLGSPLEPIELVRFAGLAEALTAGAPHYDNVAASLLGGLVI
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEE
LLNRKKPRIARLRLPPGMRIVLFIPKTMVLRLLPGKAKTQVMREVLPETIEHSDAVEWVE
EEECCCCCEEEEECCCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHH
KAVALALGLSGADPYEAIKTINYGGPIEATRAKLIPGYWEAKKEALQSGALAFNISGAGP
HHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCC
TLFAVVREGEEDQVMRRVSAVLEKYWGSLEARVVDVDYDGARLE
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]