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The map label for this gene is pth [H]

Identifier: 124027644

GI number: 124027644

Start: 757187

End: 757564

Strand: Reverse

Name: pth [H]

Synonym: Hbut_0765

Alternate gene names: 124027644

Gene position: 757564-757187 (Counterclockwise)

Preceding gene: 124027647

Following gene: 124027643

Centisome position: 45.44

GC content: 58.47

Gene sequence:

>378_bases
ATGGTGGATGGCACGGAGTATAAGCAAGTTATTGTTGTTAGGGCTGATCTAAAGATGAGCCGTGGGAAGCTGGCTGCCCA
GGCTGCTCATGCAGCTGTTGAAGCTGTACTAGAGATTCTTGACTCGGGCCATCCGGAGTGGAGGAGGTGGCTGGAGGAGT
GGAGGAGGCAGGGCCAGAAGAAGGTCGTGGTGAAGGTTGATAGCGAGGCTGAGCTGCTCCGGGTTTACCAGGAGGCGCTC
CGCCTTGGGCTCCCAACAAGCCTCATAGCTGACGCGGGGCGGACAGAGCTGCCACCCGGTACTAGGACGGCTGTGGCTGT
GGGGCCAGCGCCTTCACCTATTGTTGACCGGGTAACAGGAAAGCTAAAGCTGCTCTAG

Upstream 100 bases:

>100_bases
ATTGGCGGTGAATTATACCAGAAGACCTCAAAAGCATGATAAGATTGTGAGAGGCTAGGGATCTGCGGGATAGCAGCTGT
GGCAGCCTGGGGTGCTAATA

Downstream 100 bases:

>100_bases
TGCATCTCCTCCCACCCGGAGCCCAGCACCTCCCGGCCTTCCGGGTTCTCACGTGCAGCGGGGTGCCTAGGCGTCTTGCA
GGCACACCTCGTGATTGTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MVDGTEYKQVIVVRADLKMSRGKLAAQAAHAAVEAVLEILDSGHPEWRRWLEEWRRQGQKKVVVKVDSEAELLRVYQEAL
RLGLPTSLIADAGRTELPPGTRTAVAVGPAPSPIVDRVTGKLKLL

Sequences:

>Translated_125_residues
MVDGTEYKQVIVVRADLKMSRGKLAAQAAHAAVEAVLEILDSGHPEWRRWLEEWRRQGQKKVVVKVDSEAELLRVYQEAL
RLGLPTSLIADAGRTELPPGTRTAVAVGPAPSPIVDRVTGKLKLL
>Mature_125_residues
MVDGTEYKQVIVVRADLKMSRGKLAAQAAHAAVEAVLEILDSGHPEWRRWLEEWRRQGQKKVVVKVDSEAELLRVYQEAL
RLGLPTSLIADAGRTELPPGTRTAVAVGPAPSPIVDRVTGKLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family [H]

Homologues:

Organism=Homo sapiens, GI7706351, Length=122, Percent_Identity=49.1803278688525, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17558188, Length=124, Percent_Identity=37.0967741935484, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319414, Length=123, Percent_Identity=34.9593495934959, Blast_Score=89, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281376919, Length=120, Percent_Identity=47.5, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644665, Length=120, Percent_Identity=47.5, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646438, Length=122, Percent_Identity=41.8032786885246, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002833 [H]

Pfam domain/function: PF01981 PTH2 [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 13744; Mature: 13744

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDGTEYKQVIVVRADLKMSRGKLAAQAAHAAVEAVLEILDSGHPEWRRWLEEWRRQGQK
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
KVVVKVDSEAELLRVYQEALRLGLPTSLIADAGRTELPPGTRTAVAVGPAPSPIVDRVTG
EEEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCC
KLKLL
CEECC
>Mature Secondary Structure
MVDGTEYKQVIVVRADLKMSRGKLAAQAAHAAVEAVLEILDSGHPEWRRWLEEWRRQGQK
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
KVVVKVDSEAELLRVYQEALRLGLPTSLIADAGRTELPPGTRTAVAVGPAPSPIVDRVTG
EEEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCC
KLKLL
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]