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The map label for this gene is tmk [H]

Identifier: 124027289

GI number: 124027289

Start: 383206

End: 383877

Strand: Reverse

Name: tmk [H]

Synonym: Hbut_0397

Alternate gene names: 124027289

Gene position: 383877-383206 (Counterclockwise)

Preceding gene: 124027293

Following gene: 124027287

Centisome position: 23.03

GC content: 51.93

Gene sequence:

>672_bases
TTGGCTAGGCCCGTATATGTTGTGTTCGAGGGTATAGACGGGGCTGGAACAACAACTCATGCCAGGTTGCTGGCTGAAAA
GTTGCGTCTTCTTGGCTACTGTGTAGAGCTTGTCGAGGAGCCCTCAAAGGATGTTGTGGGCGGTGTTATTCGGCACATGC
TCCGGCACGGTCCCTTCCACCAGGATGTACTAGCGTTGCTCTTTGCCGCTGATAGGCTCCTACTGCAGCGCTCGCTTGAG
GAAAGGCTGCAGGGTAGGAGCTGCATCGTTGTAAGTGATAGGAGCTGGATTTCAAGCCTAGCATATCAGACTTGCGAACT
CTTTCCCTACGCTGTGGATGCTGACTGGGTTTATATCGTTAACAAGTATGCATGGAGGCCAGACATACTTGTATACATTG
ATGTAGAGCCTCTCATAGCTTTTCGGCGCCTTGCCTCTAGGGGCAGGGTACGCGAGCTACCTGAAACACTTGCAGCTCTT
CGTGCGCTCAGAGAGAGTTACAGGCACGTCATCCAGCGGGTTAGCCGCGTGGTGCCAGTTGTACTATGGGTTGAAGGATC
TAGGAATGGTGTAGAGAAGCCTATCGATAAGCTGTCAAGGGAGATTGCTGTACGTGTACTCGCAGCAATAAAGTACTCCG
AGCATAGAGGCGCTCTAGACTCTGATGAGTAG

Upstream 100 bases:

>100_bases
AGAGCCGTTTATCCCCAGCACCCTTATACCAGCCATACAGCACCAGCCCCCAGCTGGAAGGGCGTGGATAGCCCCACTTA
GGCGTCCGAGGGCACGAACA

Downstream 100 bases:

>100_bases
TGCTGCAAAGCCACCCGTACACTTAGACATGTGGGGGTATACGCGCTGTGTCTTCCTCATGAAGGGGCTCCATACGCCTA
TGAGGGGCTTAGCCTCCACG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MARPVYVVFEGIDGAGTTTHARLLAEKLRLLGYCVELVEEPSKDVVGGVIRHMLRHGPFHQDVLALLFAADRLLLQRSLE
ERLQGRSCIVVSDRSWISSLAYQTCELFPYAVDADWVYIVNKYAWRPDILVYIDVEPLIAFRRLASRGRVRELPETLAAL
RALRESYRHVIQRVSRVVPVVLWVEGSRNGVEKPIDKLSREIAVRVLAAIKYSEHRGALDSDE

Sequences:

>Translated_223_residues
MARPVYVVFEGIDGAGTTTHARLLAEKLRLLGYCVELVEEPSKDVVGGVIRHMLRHGPFHQDVLALLFAADRLLLQRSLE
ERLQGRSCIVVSDRSWISSLAYQTCELFPYAVDADWVYIVNKYAWRPDILVYIDVEPLIAFRRLASRGRVRELPETLAAL
RALRESYRHVIQRVSRVVPVVLWVEGSRNGVEKPIDKLSREIAVRVLAAIKYSEHRGALDSDE
>Mature_222_residues
ARPVYVVFEGIDGAGTTTHARLLAEKLRLLGYCVELVEEPSKDVVGGVIRHMLRHGPFHQDVLALLFAADRLLLQRSLEE
RLQGRSCIVVSDRSWISSLAYQTCELFPYAVDADWVYIVNKYAWRPDILVYIDVEPLIAFRRLASRGRVRELPETLAALR
ALRESYRHVIQRVSRVVPVVLWVEGSRNGVEKPIDKLSREIAVRVLAAIKYSEHRGALDSDE

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25389; Mature: 25258

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPVYVVFEGIDGAGTTTHARLLAEKLRLLGYCVELVEEPSKDVVGGVIRHMLRHGPFH
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCH
QDVLALLFAADRLLLQRSLEERLQGRSCIVVSDRSWISSLAYQTCELFPYAVDADWVYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCEEECCCCEEEE
NKYAWRPDILVYIDVEPLIAFRRLASRGRVRELPETLAALRALRESYRHVIQRVSRVVPV
EHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VLWVEGSRNGVEKPIDKLSREIAVRVLAAIKYSEHRGALDSDE
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ARPVYVVFEGIDGAGTTTHARLLAEKLRLLGYCVELVEEPSKDVVGGVIRHMLRHGPFH
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCH
QDVLALLFAADRLLLQRSLEERLQGRSCIVVSDRSWISSLAYQTCELFPYAVDADWVYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCCEEECCCCEEEE
NKYAWRPDILVYIDVEPLIAFRRLASRGRVRELPETLAALRALRESYRHVIQRVSRVVPV
EHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VLWVEGSRNGVEKPIDKLSREIAVRVLAAIKYSEHRGALDSDE
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]