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The map label for this gene is ahpC [C]

Identifier: 124025740

GI number: 124025740

Start: 952360

End: 952956

Strand: Direct

Name: ahpC [C]

Synonym: NATL1_10331

Alternate gene names: 124025740

Gene position: 952360-952956 (Clockwise)

Preceding gene: 124025738

Following gene: 124025742

Centisome position: 51.07

GC content: 37.19

Gene sequence:

>597_bases
ATGACGACAAATGAGTGCCTAAGGGTAGGAATGCAAGCACCAGATTTTGCTACAACAGCAGTAGTAGATCAAGAATTTAA
GGACATAACACTTTCTCAGTACAGAGGAAAGTATGTTGTTCTATTTTTCTATCCATTAGACTTCACGTTTGTTTGCCCTA
CTGAAATCACGGCCTTCAGTGACAGATATAGCGATTTCAGTAGTAAAAACACAGAAGTTTTAGGTGTTTCGGTTGATAGT
AAATTTACACATCTTGCATGGATTCAAACACCAAGGAATGAGGGAGGAATTGGTGACATTAACTATCCACTAGTATCTGA
TTTAAAACGTGAAATTTGCCAATCTTATAATGTTTTAAATGAGGATGGAGAAGCTGATAGAGGTTTATTTATAATTAATC
CAAGCGGAATAATTATGCACTCAACAATCAATAAAGCACCTGTTGGCCGAAATATAGACGAAACTCTAAGAGTATTACAG
GCATATCAATACGTTGAATCTCACCCTGATGAAGTATGTCCAGCAGGATGGACTCCTGGTGACAAAACCATGAAAGAAGA
TCCTAAAGGAAGCAAGGAATACTTCTCTGCACTATAA

Upstream 100 bases:

>100_bases
TAGAAAGAGTAAGTCTCTTTGATCTTTACATGATAAATTATAAAGAGGAAAAGGGGAATTTCTCTACTCTCCAAACCATT
CAAAATACGAAACAAATTCC

Downstream 100 bases:

>100_bases
AAATTATAGATAATATTTACTTAGTTGCTAGATAAGTAAGAATTAAGTGAATCAATTATAAAATCAGATTCAAGAGTTTC
CTTAACTATTAATTCATCAA

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTTNECLRVGMQAPDFATTAVVDQEFKDITLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYSDFSSKNTEVLGVSVDS
KFTHLAWIQTPRNEGGIGDINYPLVSDLKREICQSYNVLNEDGEADRGLFIINPSGIIMHSTINKAPVGRNIDETLRVLQ
AYQYVESHPDEVCPAGWTPGDKTMKEDPKGSKEYFSAL

Sequences:

>Translated_198_residues
MTTNECLRVGMQAPDFATTAVVDQEFKDITLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYSDFSSKNTEVLGVSVDS
KFTHLAWIQTPRNEGGIGDINYPLVSDLKREICQSYNVLNEDGEADRGLFIINPSGIIMHSTINKAPVGRNIDETLRVLQ
AYQYVESHPDEVCPAGWTPGDKTMKEDPKGSKEYFSAL
>Mature_197_residues
TTNECLRVGMQAPDFATTAVVDQEFKDITLSQYRGKYVVLFFYPLDFTFVCPTEITAFSDRYSDFSSKNTEVLGVSVDSK
FTHLAWIQTPRNEGGIGDINYPLVSDLKREICQSYNVLNEDGEADRGLFIINPSGIIMHSTINKAPVGRNIDETLRVLQA
YQYVESHPDEVCPAGWTPGDKTMKEDPKGSKEYFSAL

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=190, Percent_Identity=61.0526315789474, Blast_Score=242, Evalue=1e-64,
Organism=Homo sapiens, GI32483377, Length=194, Percent_Identity=58.2474226804124, Blast_Score=237, Evalue=5e-63,
Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=59.6858638743455, Blast_Score=236, Evalue=7e-63,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=59.6858638743455, Blast_Score=236, Evalue=7e-63,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=59.6858638743455, Blast_Score=236, Evalue=7e-63,
Organism=Homo sapiens, GI5802974, Length=188, Percent_Identity=59.0425531914894, Blast_Score=236, Evalue=8e-63,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=57.2916666666667, Blast_Score=230, Evalue=5e-61,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=69.3181818181818, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=28.042328042328, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786822, Length=170, Percent_Identity=38.8235294117647, Blast_Score=136, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=60.6382978723404, Blast_Score=235, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=60.6382978723404, Blast_Score=235, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=52.6881720430108, Blast_Score=208, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25153706, Length=179, Percent_Identity=26.2569832402235, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=51.3089005235602, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320661, Length=188, Percent_Identity=50.531914893617, Blast_Score=190, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319407, Length=188, Percent_Identity=29.7872340425532, Blast_Score=95, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24656348, Length=185, Percent_Identity=58.3783783783784, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17864676, Length=185, Percent_Identity=58.3783783783784, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=55.1546391752577, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI17157991, Length=184, Percent_Identity=57.0652173913043, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24641739, Length=184, Percent_Identity=57.0652173913043, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=48.4210526315789, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17975518, Length=188, Percent_Identity=32.4468085106383, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=31.9148936170213, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24652434, Length=188, Percent_Identity=31.9148936170213, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581278, Length=190, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22259; Mature: 22128

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNECLRVGMQAPDFATTAVVDQEFKDITLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CCHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHCCCCEEEEEEECCCEEEECCCHHHHHH
DRYSDFSSKNTEVLGVSVDSKFTHLAWIQTPRNEGGIGDINYPLVSDLKREICQSYNVLN
HHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EDGEADRGLFIINPSGIIMHSTINKAPVGRNIDETLRVLQAYQYVESHPDEVCPAGWTPG
CCCCCCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DKTMKEDPKGSKEYFSAL
CCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TTNECLRVGMQAPDFATTAVVDQEFKDITLSQYRGKYVVLFFYPLDFTFVCPTEITAFS
CHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHCCCCEEEEEEECCCEEEECCCHHHHHH
DRYSDFSSKNTEVLGVSVDSKFTHLAWIQTPRNEGGIGDINYPLVSDLKREICQSYNVLN
HHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EDGEADRGLFIINPSGIIMHSTINKAPVGRNIDETLRVLQAYQYVESHPDEVCPAGWTPG
CCCCCCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DKTMKEDPKGSKEYFSAL
CCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]