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The map label for this gene is dxs

Identifier: 124025679

GI number: 124025679

Start: 892530

End: 894416

Strand: Direct

Name: dxs

Synonym: NATL1_09721

Alternate gene names: 124025679

Gene position: 892530-894416 (Clockwise)

Preceding gene: 124025675

Following gene: 124025684

Centisome position: 47.86

GC content: 38.84

Gene sequence:

>1887_bases
ATGCGTCTGAGCCAGTTAAGTCATCCGAATGAGCTTCATGGCTTAGCCATTAGTGAATTGGAAGATGTTGCTTGCCAAAT
TAGAGAAAGGCATCTTCAAGTAGTTTCTACTAGTGGTGGGCACTTAGGTCCAGGTCTTGGTGTTGTTGAGTTAACAATTG
CTCTCTATCAGACTTTAGATCTAGATGTAGATAAAGTTATTTGGGATGTTGGACATCAAGCTTATCCTCACAAGTTACTT
ACGGGAAGATATAACCGATTTGATTCTCTCAGACAGCAAAAAGGCGTAGCTGGTTATCTAAAAAGAACAGAAAGTAAATT
TGATCATTTTGGAGCTGGACATGCGAGCACATCAATTTCAGCCGCTCTTGGTATGGCTATTGCCAGAGACCGAAAAGGGG
AAGATTATAAATGTGTTGCGGTAATTGGAGATGGTGCTCTTACCGGTGGAATGGCTTTAGAGGCTATTAATCATGCAGGA
CATCTTCCAAAAACACCTCTTTTGGTTGTCCTAAATGATAATGATATGTCGATTTCTCCTCCTGTTGGAGCATTATCGAC
TTATTTAAATCGTATGCGTCATAGCCCGCCTGTTCAATTCATATCTGATAGTGTCCAAGAAAGTGTGAAAAATCTTCCTT
TCATGGGAGATGCTATGCAAGAGGAATTTAAATCTCTTACAGGCAGTGTTAGACGTTTAGCAGTTCCAAGTGTTGGTGCA
GTTTTTGAGGAATTGGGTTTTACTTATATGGGTCCTGTAGATGGGCATGATATTGCTGAATTGACTAGAACCTTTAATGC
TGCGCATAAAGTTGGTGGACCTGTTATGGTCCATGTCGCTACTACAAAGGGAAAAGGTTATCCATATGCTGAAGCTGATC
AGGTTGGTTACCATGCTCAGTCTTCCTTTGATCTAACAACAGGAAAATCTATTCCTTCTAAAACTCCTAAACCTCCAAGT
TTTAGCAAGGTATTTGGTCAAACTTTAGTAAAACTTTGCGAGCAAGACAGCAAAATTGTAGGTATTACTGCTGCAATGGC
AGAAGGCACAGCTTTAAATCTTTTACAGAAAGCTATTCCTGATCAATATGTTGATGTTGGTATAGCAGAACAACATGCTG
TAACTCTTGCTGGTGGTATGGCTTGCGAAGGTATCAAACCAGTTGTTGCCATTTACAGTACTTTTTTACAACGTGCATAT
GATCAGTTGATCCATGATATTGGAATACAGAATTTACCTGTAACTTTCGTATTAGATAGAGCTGGAATTGTTGGTGCTGA
TGGTCCAACTCATCAAGGGCAATATGACATTAGTTATTTAAGGTGTATTCCTAACTTTACTGTTATGGCTCCAAAAGATG
AGTCTGAATTGCAGCAAATGCTGGTTACATGTATTAATCACAATGGTCCATCAGCTTTAAGGATACCTAGAGGTTCTGGA
GAAGGAGCAGCTTTGATGGAGGAAGGATGGGAATCTCTAGAAATTGGTAAAGCTGAGACTATAGAAGAGGGCGAAAACTT
ATTAATAATTGGTTATGGCTCTATGGTTTTCCCAGCAATTAAAACTGCAGCAATACTGAAAGAATTTGGAGTGAATTGTA
CTGTTATTAATGCTCGCTTCATAAGACCATTAGACGAGGATACTATTCATGAGGCAGCAAAAAGAATAGGCAAAGTAGTA
ACAATGGAAGAAGGAACACTATTGGGCGGCTTTGGATCTGCTGTTGTTGAATCTTTTAATGATAATGATATTTTTGTCCC
TACATTAAGAATTGGAATACCTGATAAATTAGTCGATCATGCAACGCCGCAACAAAGCAAGGAATCGCTTGGATTAACTC
CCGAAATGATGGCTGATCAAATTAGAAATAAATTTAATTTTAATTAA

Upstream 100 bases:

>100_bases
TTTGATTCTTGTGTTTTCTACATTCCATTTGTTCTTGTGCAAGTTTTATCAAAATGTACGGTAGACCTCGTAGATTGGAG
GAATTCAATCTCAGAGTTAT

Downstream 100 bases:

>100_bases
TTATCAAACAATAAAAAAAGGATTATTGATTAATAATCCTTTTTTTTCTATTTAATTTAGTAACTTAATTTATAAAACGC
CTCTAGCAGCAAGACCCAAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MRLSQLSHPNELHGLAISELEDVACQIRERHLQVVSTSGGHLGPGLGVVELTIALYQTLDLDVDKVIWDVGHQAYPHKLL
TGRYNRFDSLRQQKGVAGYLKRTESKFDHFGAGHASTSISAALGMAIARDRKGEDYKCVAVIGDGALTGGMALEAINHAG
HLPKTPLLVVLNDNDMSISPPVGALSTYLNRMRHSPPVQFISDSVQESVKNLPFMGDAMQEEFKSLTGSVRRLAVPSVGA
VFEELGFTYMGPVDGHDIAELTRTFNAAHKVGGPVMVHVATTKGKGYPYAEADQVGYHAQSSFDLTTGKSIPSKTPKPPS
FSKVFGQTLVKLCEQDSKIVGITAAMAEGTALNLLQKAIPDQYVDVGIAEQHAVTLAGGMACEGIKPVVAIYSTFLQRAY
DQLIHDIGIQNLPVTFVLDRAGIVGADGPTHQGQYDISYLRCIPNFTVMAPKDESELQQMLVTCINHNGPSALRIPRGSG
EGAALMEEGWESLEIGKAETIEEGENLLIIGYGSMVFPAIKTAAILKEFGVNCTVINARFIRPLDEDTIHEAAKRIGKVV
TMEEGTLLGGFGSAVVESFNDNDIFVPTLRIGIPDKLVDHATPQQSKESLGLTPEMMADQIRNKFNFN

Sequences:

>Translated_628_residues
MRLSQLSHPNELHGLAISELEDVACQIRERHLQVVSTSGGHLGPGLGVVELTIALYQTLDLDVDKVIWDVGHQAYPHKLL
TGRYNRFDSLRQQKGVAGYLKRTESKFDHFGAGHASTSISAALGMAIARDRKGEDYKCVAVIGDGALTGGMALEAINHAG
HLPKTPLLVVLNDNDMSISPPVGALSTYLNRMRHSPPVQFISDSVQESVKNLPFMGDAMQEEFKSLTGSVRRLAVPSVGA
VFEELGFTYMGPVDGHDIAELTRTFNAAHKVGGPVMVHVATTKGKGYPYAEADQVGYHAQSSFDLTTGKSIPSKTPKPPS
FSKVFGQTLVKLCEQDSKIVGITAAMAEGTALNLLQKAIPDQYVDVGIAEQHAVTLAGGMACEGIKPVVAIYSTFLQRAY
DQLIHDIGIQNLPVTFVLDRAGIVGADGPTHQGQYDISYLRCIPNFTVMAPKDESELQQMLVTCINHNGPSALRIPRGSG
EGAALMEEGWESLEIGKAETIEEGENLLIIGYGSMVFPAIKTAAILKEFGVNCTVINARFIRPLDEDTIHEAAKRIGKVV
TMEEGTLLGGFGSAVVESFNDNDIFVPTLRIGIPDKLVDHATPQQSKESLGLTPEMMADQIRNKFNFN
>Mature_628_residues
MRLSQLSHPNELHGLAISELEDVACQIRERHLQVVSTSGGHLGPGLGVVELTIALYQTLDLDVDKVIWDVGHQAYPHKLL
TGRYNRFDSLRQQKGVAGYLKRTESKFDHFGAGHASTSISAALGMAIARDRKGEDYKCVAVIGDGALTGGMALEAINHAG
HLPKTPLLVVLNDNDMSISPPVGALSTYLNRMRHSPPVQFISDSVQESVKNLPFMGDAMQEEFKSLTGSVRRLAVPSVGA
VFEELGFTYMGPVDGHDIAELTRTFNAAHKVGGPVMVHVATTKGKGYPYAEADQVGYHAQSSFDLTTGKSIPSKTPKPPS
FSKVFGQTLVKLCEQDSKIVGITAAMAEGTALNLLQKAIPDQYVDVGIAEQHAVTLAGGMACEGIKPVVAIYSTFLQRAY
DQLIHDIGIQNLPVTFVLDRAGIVGADGPTHQGQYDISYLRCIPNFTVMAPKDESELQQMLVTCINHNGPSALRIPRGSG
EGAALMEEGWESLEIGKAETIEEGENLLIIGYGSMVFPAIKTAAILKEFGVNCTVINARFIRPLDEDTIHEAAKRIGKVV
TMEEGTLLGGFGSAVVESFNDNDIFVPTLRIGIPDKLVDHATPQQSKESLGLTPEMMADQIRNKFNFN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=512, Percent_Identity=23.6328125, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4507521, Length=512, Percent_Identity=23.6328125, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI133778974, Length=638, Percent_Identity=23.3542319749216, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI225637461, Length=397, Percent_Identity=26.7002518891688, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637459, Length=397, Percent_Identity=26.7002518891688, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=397, Percent_Identity=26.7002518891688, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4557353, Length=236, Percent_Identity=23.728813559322, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI34101272, Length=236, Percent_Identity=23.728813559322, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI156564403, Length=300, Percent_Identity=24.6666666666667, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=44.122383252818, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539652, Length=417, Percent_Identity=27.5779376498801, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538422, Length=255, Percent_Identity=24.7058823529412, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=202, Percent_Identity=23.2673267326733, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=318, Percent_Identity=24.8427672955975, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551847, Length=650, Percent_Identity=24, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45550715, Length=650, Percent_Identity=24, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24645119, Length=546, Percent_Identity=24.9084249084249, Blast_Score=134, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24666278, Length=633, Percent_Identity=22.9067930489731, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI160714832, Length=237, Percent_Identity=24.4725738396624, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI160714828, Length=237, Percent_Identity=24.4725738396624, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358145, Length=245, Percent_Identity=24.8979591836735, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650940, Length=245, Percent_Identity=24.8979591836735, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PROM1 (A2C220)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014795.1
- ProteinModelPortal:   A2C220
- SMR:   A2C220
- STRING:   A2C220
- GeneID:   4780095
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_09721
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   PMAR167555:NATL1_09721-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67828; Mature: 67828

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSQLSHPNELHGLAISELEDVACQIRERHLQVVSTSGGHLGPGLGVVELTIALYQTLD
CCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDVDKVIWDVGHQAYPHKLLTGRYNRFDSLRQQKGVAGYLKRTESKFDHFGAGHASTSIS
CCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAIARDRKGEDYKCVAVIGDGALTGGMALEAINHAGHLPKTPLLVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTYLNRMRHSPPVQFISDSVQESVKNLPFMGDAMQEEFKSLTGSVRRLAVPSVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPVDGHDIAELTRTFNAAHKVGGPVMVHVATTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SSFDLTTGKSIPSKTPKPPSFSKVFGQTLVKLCEQDSKIVGITAAMAEGTALNLLQKAIP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHCC
DQYVDVGIAEQHAVTLAGGMACEGIKPVVAIYSTFLQRAYDQLIHDIGIQNLPVTFVLDR
HHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYLRCIPNFTVMAPKDESELQQMLVTCINHNGPSALRIPRGSG
CCEECCCCCCCCCCCCHHHHEECCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
EGAALMEEGWESLEIGKAETIEEGENLLIIGYGSMVFPAIKTAAILKEFGVNCTVINARF
CCCHHHHCCCHHHCCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHC
IRPLDEDTIHEAAKRIGKVVTMEEGTLLGGFGSAVVESFNDNDIFVPTLRIGIPDKLVDH
CCCCCHHHHHHHHHHHCCEEEECCCCEECCCHHHHHHCCCCCCEEEEEEEECCCHHHHHC
ATPQQSKESLGLTPEMMADQIRNKFNFN
CCCCHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLSQLSHPNELHGLAISELEDVACQIRERHLQVVSTSGGHLGPGLGVVELTIALYQTLD
CCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDVDKVIWDVGHQAYPHKLLTGRYNRFDSLRQQKGVAGYLKRTESKFDHFGAGHASTSIS
CCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAIARDRKGEDYKCVAVIGDGALTGGMALEAINHAGHLPKTPLLVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTYLNRMRHSPPVQFISDSVQESVKNLPFMGDAMQEEFKSLTGSVRRLAVPSVGA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
VFEELGFTYMGPVDGHDIAELTRTFNAAHKVGGPVMVHVATTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SSFDLTTGKSIPSKTPKPPSFSKVFGQTLVKLCEQDSKIVGITAAMAEGTALNLLQKAIP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHCC
DQYVDVGIAEQHAVTLAGGMACEGIKPVVAIYSTFLQRAYDQLIHDIGIQNLPVTFVLDR
HHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYLRCIPNFTVMAPKDESELQQMLVTCINHNGPSALRIPRGSG
CCEECCCCCCCCCCCCHHHHEECCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
EGAALMEEGWESLEIGKAETIEEGENLLIIGYGSMVFPAIKTAAILKEFGVNCTVINARF
CCCHHHHCCCHHHCCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHC
IRPLDEDTIHEAAKRIGKVVTMEEGTLLGGFGSAVVESFNDNDIFVPTLRIGIPDKLVDH
CCCCCHHHHHHHHHHHCCEEEECCCCEECCCHHHHHHCCCCCCEEEEEEEECCCHHHHHC
ATPQQSKESLGLTPEMMADQIRNKFNFN
CCCCHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA