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The map label for this gene is rfbC [H]

Identifier: 124025562

GI number: 124025562

Start: 784866

End: 785447

Strand: Direct

Name: rfbC [H]

Synonym: NATL1_08551

Alternate gene names: 124025562

Gene position: 784866-785447 (Clockwise)

Preceding gene: 124025561

Following gene: 124025563

Centisome position: 42.09

GC content: 34.02

Gene sequence:

>582_bases
ATGGAATACACAACACTAAGCAATGAAAAAGAAGAAATTGAGGGTCCCTTGCTTCTTACTCCAAATGTTTTCAATGATGA
AAGAGGATATTTTTACGAAAGTTGGAACGAAAAAATTTTTAATTCAATCTTAGGGAAAGAGGTCAGATTTAAACAAGATA
ATATTTCTCATTCAATAAAAGGAGTATTGAGAGGGCTTCATTATCAATTAAAACCTGAGTCACAAGGGAAGTTAGTTCGA
TGTAGTTATGGCTCAATTTTTGATGTTGCAGTTGACATTAGGAAAGAATCTAAAACCTTCGGTAAATGGCTTAGTGCAGA
GCTTAGTTCCGAAAATAAAAAACAATTATGGATACCAGTTGGATTTGCACATGGATTTCTAACTATTAGTGATCATGCTG
AAGTTAATTACAAAGCAACGGGATTCTGGAATAAAGACTGCGAACACTCTATTCGCTGGAATGACAAAGACTTGAAAATA
ACTTGGCCTATAAAGGAGTTTGGCTTTGAACCAGTCATTAACGAAAAAGATGCATCTGCTCCTTTCTTGAAAGAGTCAAT
AATGAAAGGGAACATATTTTAA

Upstream 100 bases:

>100_bases
TTGCTAGACCATTATTTAAAAGTTGTTATGGCACATACCTACTAAATTTATTAAAAGAACATCAATCCCATTTTTAATAG
ATATAAACACAATTTTTAAA

Downstream 100 bases:

>100_bases
TGAAAGTTTTACTCACAGGAGCATCAGGACAACTAGGGCAAGCAATCATTAAATCAAAGCCATCTTTTGTTGAGCTAATA
GCCACAACTCGACGTGAACT

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MEYTTLSNEKEEIEGPLLLTPNVFNDERGYFYESWNEKIFNSILGKEVRFKQDNISHSIKGVLRGLHYQLKPESQGKLVR
CSYGSIFDVAVDIRKESKTFGKWLSAELSSENKKQLWIPVGFAHGFLTISDHAEVNYKATGFWNKDCEHSIRWNDKDLKI
TWPIKEFGFEPVINEKDASAPFLKESIMKGNIF

Sequences:

>Translated_193_residues
MEYTTLSNEKEEIEGPLLLTPNVFNDERGYFYESWNEKIFNSILGKEVRFKQDNISHSIKGVLRGLHYQLKPESQGKLVR
CSYGSIFDVAVDIRKESKTFGKWLSAELSSENKKQLWIPVGFAHGFLTISDHAEVNYKATGFWNKDCEHSIRWNDKDLKI
TWPIKEFGFEPVINEKDASAPFLKESIMKGNIF
>Mature_193_residues
MEYTTLSNEKEEIEGPLLLTPNVFNDERGYFYESWNEKIFNSILGKEVRFKQDNISHSIKGVLRGLHYQLKPESQGKLVR
CSYGSIFDVAVDIRKESKTFGKWLSAELSSENKKQLWIPVGFAHGFLTISDHAEVNYKATGFWNKDCEHSIRWNDKDLKI
TWPIKEFGFEPVINEKDASAPFLKESIMKGNIF

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=154, Percent_Identity=55.1948051948052, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17550412, Length=162, Percent_Identity=45.679012345679, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 22361; Mature: 22361

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYTTLSNEKEEIEGPLLLTPNVFNDERGYFYESWNEKIFNSILGKEVRFKQDNISHSIK
CCCCCCCCCHHHCCCCEEECCCCCCCCCCCEEHHHHHHHHHHHHCCCEEECCCCHHHHHH
GVLRGLHYQLKPESQGKLVRCSYGSIFDVAVDIRKESKTFGKWLSAELSSENKKQLWIPV
HHHHHCCEEECCCCCCCEEEEECCCEEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEE
GFAHGFLTISDHAEVNYKATGFWNKDCEHSIRWNDKDLKITWPIKEFGFEPVINEKDASA
EECCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECHHHHCCCCCCCCCCCCC
PFLKESIMKGNIF
CHHHHHHHCCCCC
>Mature Secondary Structure
MEYTTLSNEKEEIEGPLLLTPNVFNDERGYFYESWNEKIFNSILGKEVRFKQDNISHSIK
CCCCCCCCCHHHCCCCEEECCCCCCCCCCCEEHHHHHHHHHHHHCCCEEECCCCHHHHHH
GVLRGLHYQLKPESQGKLVRCSYGSIFDVAVDIRKESKTFGKWLSAELSSENKKQLWIPV
HHHHHCCEEECCCCCCCEEEEECCCEEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEE
GFAHGFLTISDHAEVNYKATGFWNKDCEHSIRWNDKDLKITWPIKEFGFEPVINEKDASA
EECCCEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECHHHHCCCCCCCCCCCCC
PFLKESIMKGNIF
CHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 10802738 [H]