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The map label for this gene is purK [H]

Identifier: 124025450

GI number: 124025450

Start: 684650

End: 685795

Strand: Direct

Name: purK [H]

Synonym: NATL1_07431

Alternate gene names: 124025450

Gene position: 684650-685795 (Clockwise)

Preceding gene: 124025448

Following gene: 124025453

Centisome position: 36.72

GC content: 37.35

Gene sequence:

>1146_bases
ATGATTGGGGTCGTGGGTGGAGGACAGCTTGCAATGCTTTTGATTGAGGCTGGAAAGAAAAGAAATGTTGATGTCGTTGT
TCAGACGGCTGCTAAAACTGATCCTGCTGCTAAAAAGACAAATCAACTCGTTTTGCATGACCCTACGAATCCTGTGGGTA
CAAAACTTCTTGCAGAAAAGACCCGCTTGATTACTTTTGAAAATGAATGGGTTGATATCTCAAGTTTACTTTCTCTTGAA
AATAATGGAGTTTCTTTTGTCCCTAGACTTCAATCAATAAGACCTTTAATTAATAAAATAACTCAAAGGGAGCTATTAAA
CAGTCTTGATATTCCCTGCCCTGATTGGTTGTCTATACCATTAAAAAAATCAACAGAAATTGATCTTCCTGCAGATTGGG
GATTTCCTTTGATGGCAAAAGCTGCCAAAGGTGGATATGACGGGAAAGGAACTAAAATTATTAAAAATCTAAAGCAACTT
CAAGAATTTCTATCAGTTGAAAGAGAAGGGCAATGGATGTTAGAGAAATGGATCTCTTTTGATAAGGAATTATCCATTGT
TTCTAGTAGGGATTCAAAAGGAATTGTACGTAGTCTGCCAATCGTAGAGACATATCAATCTAAACAAGTATGTGACTGGG
TCCTTGCTCCAGCTGATATCAATCATGACGTTGATCTTATGGTTAGAAATATCGCAGCTTCGTTGCTTGCTGAGTTGCAA
TATGTTGGAGTTATTGCTATTGAATTTTTCTATGGATCTGAAGGATTACTTGTAAATGAAATAGCTCCAAGAACTCATAA
CTCAGGTCATTTTTCTATTGATGCTTGTAGCAGCAGTCAGTTTGATCAACAAATATGTATCACCTCTGGTATTGATGTAC
CCATGCCTGAAATGCTTGTTAATGGTGCTTTAATGGCAAACTTGCTTGGTTTGCAAAGTAACTATCCAACATCACTTACC
CAAAGATTGAATGATTTGAGGGGTATTCCTGGCTTGAATGTTCATTGGTATGAAAAAGAGGAAGAAAAAAAGGGCAGGAA
GCTTGGTCACGTTACATATCTCTTGAATAATAAGGACGCTTTGTCTAGAAAAAAAGAAGCATTAGATGTTTTACAAACCA
TACGGTCAATTTGGCCGACCTCTTGA

Upstream 100 bases:

>100_bases
TTTTTATTAAAATCAGACTTCATACATTATTTTATTTGTTTGTTCGCGATTTTGTTATTTGCTTGCTAAGCAATGCTCTA
AAAATGAGGTCTTTAACTAA

Downstream 100 bases:

>100_bases
TAATATTTCTTTTAGATTGTTCCAGTACTGCTTTGTTGGTATAGGCCTTCTCAAGTGCTCTGATCTGACTCTCTTTCGAT
TTGGGGAAGCTGTCGTGAAA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIGVVGGGQLAMLLIEAGKKRNVDVVVQTAAKTDPAAKKTNQLVLHDPTNPVGTKLLAEKTRLITFENEWVDISSLLSLE
NNGVSFVPRLQSIRPLINKITQRELLNSLDIPCPDWLSIPLKKSTEIDLPADWGFPLMAKAAKGGYDGKGTKIIKNLKQL
QEFLSVEREGQWMLEKWISFDKELSIVSSRDSKGIVRSLPIVETYQSKQVCDWVLAPADINHDVDLMVRNIAASLLAELQ
YVGVIAIEFFYGSEGLLVNEIAPRTHNSGHFSIDACSSSQFDQQICITSGIDVPMPEMLVNGALMANLLGLQSNYPTSLT
QRLNDLRGIPGLNVHWYEKEEEKKGRKLGHVTYLLNNKDALSRKKEALDVLQTIRSIWPTS

Sequences:

>Translated_381_residues
MIGVVGGGQLAMLLIEAGKKRNVDVVVQTAAKTDPAAKKTNQLVLHDPTNPVGTKLLAEKTRLITFENEWVDISSLLSLE
NNGVSFVPRLQSIRPLINKITQRELLNSLDIPCPDWLSIPLKKSTEIDLPADWGFPLMAKAAKGGYDGKGTKIIKNLKQL
QEFLSVEREGQWMLEKWISFDKELSIVSSRDSKGIVRSLPIVETYQSKQVCDWVLAPADINHDVDLMVRNIAASLLAELQ
YVGVIAIEFFYGSEGLLVNEIAPRTHNSGHFSIDACSSSQFDQQICITSGIDVPMPEMLVNGALMANLLGLQSNYPTSLT
QRLNDLRGIPGLNVHWYEKEEEKKGRKLGHVTYLLNNKDALSRKKEALDVLQTIRSIWPTS
>Mature_381_residues
MIGVVGGGQLAMLLIEAGKKRNVDVVVQTAAKTDPAAKKTNQLVLHDPTNPVGTKLLAEKTRLITFENEWVDISSLLSLE
NNGVSFVPRLQSIRPLINKITQRELLNSLDIPCPDWLSIPLKKSTEIDLPADWGFPLMAKAAKGGYDGKGTKIIKNLKQL
QEFLSVEREGQWMLEKWISFDKELSIVSSRDSKGIVRSLPIVETYQSKQVCDWVLAPADINHDVDLMVRNIAASLLAELQ
YVGVIAIEFFYGSEGLLVNEIAPRTHNSGHFSIDACSSSQFDQQICITSGIDVPMPEMLVNGALMANLLGLQSNYPTSLT
QRLNDLRGIPGLNVHWYEKEEEKKGRKLGHVTYLLNNKDALSRKKEALDVLQTIRSIWPTS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=373, Percent_Identity=29.2225201072386, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=364, Percent_Identity=33.7912087912088, Blast_Score=199, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42341; Mature: 42341

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVVGGGQLAMLLIEAGKKRNVDVVVQTAAKTDPAAKKTNQLVLHDPTNPVGTKLLAEK
CEEECCCCCEEEHEECCCCCCCCEEEEEECCCCCCCHHCCCEEEEECCCCCHHHHHHHCC
TRLITFENEWVDISSLLSLENNGVSFVPRLQSIRPLINKITQRELLNSLDIPCPDWLSIP
EEEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LKKSTEIDLPADWGFPLMAKAAKGGYDGKGTKIIKNLKQLQEFLSVEREGQWMLEKWISF
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DKELSIVSSRDSKGIVRSLPIVETYQSKQVCDWVLAPADINHDVDLMVRNIAASLLAELQ
CCCEEEEECCCCCCHHHHCCCHHHHCCHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
YVGVIAIEFFYGSEGLLVNEIAPRTHNSGHFSIDACSSSQFDQQICITSGIDVPMPEMLV
HHEEEEEEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCEEHEECCCCCCCHHHHH
NGALMANLLGLQSNYPTSLTQRLNDLRGIPGLNVHWYEKEEEKKGRKLGHVTYLLNNKDA
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCEEEEEEEEECCCHH
LSRKKEALDVLQTIRSIWPTS
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIGVVGGGQLAMLLIEAGKKRNVDVVVQTAAKTDPAAKKTNQLVLHDPTNPVGTKLLAEK
CEEECCCCCEEEHEECCCCCCCCEEEEEECCCCCCCHHCCCEEEEECCCCCHHHHHHHCC
TRLITFENEWVDISSLLSLENNGVSFVPRLQSIRPLINKITQRELLNSLDIPCPDWLSIP
EEEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LKKSTEIDLPADWGFPLMAKAAKGGYDGKGTKIIKNLKQLQEFLSVEREGQWMLEKWISF
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DKELSIVSSRDSKGIVRSLPIVETYQSKQVCDWVLAPADINHDVDLMVRNIAASLLAELQ
CCCEEEEECCCCCCHHHHCCCHHHHCCHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
YVGVIAIEFFYGSEGLLVNEIAPRTHNSGHFSIDACSSSQFDQQICITSGIDVPMPEMLV
HHEEEEEEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCEEHEECCCCCCCHHHHH
NGALMANLLGLQSNYPTSLTQRLNDLRGIPGLNVHWYEKEEEKKGRKLGHVTYLLNNKDA
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHCCCEEEEEEEEECCCHH
LSRKKEALDVLQTIRSIWPTS
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA