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The map label for this gene is aroB

Identifier: 124025449

GI number: 124025449

Start: 683270

End: 684376

Strand: Reverse

Name: aroB

Synonym: NATL1_07421

Alternate gene names: 124025449

Gene position: 684376-683270 (Counterclockwise)

Preceding gene: 124025451

Following gene: 124025447

Centisome position: 36.7

GC content: 36.13

Gene sequence:

>1107_bases
GTGAATAAGGACAACCACCATATTAAAGTCTCTCTAACTAACAACCCATACGAAATAGTTATTGGAAAAAATAGTCTTGA
AAGCATAGGAGATGAGTTATTTAATATTGGTTTTAGGGAAGGACTAAAAGTATTAGTCGTGTCCAACAAGGAAGTCTCTG
ATCACTATGGTGATTGCATAATCAAAAGTCTGATAAAAAGTAAATTCAAACCAAAGCTTTTGATAATAAAAGCTGGAGAA
GATCAAAAAAATCAATCTTCTATAGATTTAATCCACAATGCGGCATATGAAGCGAGGTTAGAGAGAGGATCATTAATGAT
TGCCCTTGGAGGTGGCGTGATTGGAGATATGACTGGCTTTGCAGCTGCTACATGGTTGCGTGGAGTAAATGTAGTCCAAA
TCCCCACCACATTACTCGCCATGGTTGATGCTTCTATTGGTGGTAAAACAGGGATAAATCATTCAAAAGGTAAAAATCTT
ATAGGTGCTTTTCATCAACCTAGACTGGTCTTAATAGACCCTAAAACATTAATTTCTCTCCCATCACGAGAGTTCAAAGC
AGGTATGGCTGAAATAATAAAGTACGGAGTTATATCAGACTTAGAACTATTCGATCTTCTTGAAAGGCAAGAAAATATTG
CTGATCTTTCAAACATAAAAGAAAAACTACTATTAGAAATAATTAAGCGTTCTGCTAAATCTAAAGCAGAAATTGTTATA
AAAGATGAGAAGGAAAGTGGAGTTAGAGCATTTTTAAATTATGGTCACACATTTGGCCACGTAATAGAAAATCTTTGTGG
TTATGGAAAATGGCTGCATGGCGAGGCAGTTGCAATGGGTATGGTTGCAGTTGGTCAGTTAGCGGTTCAGAGGGGACTAT
GGAACGAGGATAACGCGAAAAGGCAGAAACGATTAATAGAGAAAGCAGGCTTACCCTCTAATTGGCCTAAGCTTGATATA
GAAAGTGTTCTAAGCTCACTTCAAGGAGACAAGAAAGTTAAGAACGGCAAGGTGAGTTTCGTTATGCCCTTAAAAATTGG
TGATGTAAAATTATTTAATAATATTTCTAATAAAGAAATACGTGAATGCTTGCAAAAAATTAGCTAA

Upstream 100 bases:

>100_bases
TATCATTTACCTATAAAATGTGTTCATCAACCATATAATTATTTCTATATTTTGATGATTTAACGTAATAAACCATCAAA
CAATTTATACCCTCACAACT

Downstream 100 bases:

>100_bases
TTGGCTCTTCAAGAAAACGGTTTCTTAAAATCAAATCATCACTATTATCCTTCTGAAAAGCCAACCACCTAAAGTCACCT
AGTCCAATTGGATCAACTAG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNKDNHHIKVSLTNNPYEIVIGKNSLESIGDELFNIGFREGLKVLVVSNKEVSDHYGDCIIKSLIKSKFKPKLLIIKAGE
DQKNQSSIDLIHNAAYEARLERGSLMIALGGGVIGDMTGFAAATWLRGVNVVQIPTTLLAMVDASIGGKTGINHSKGKNL
IGAFHQPRLVLIDPKTLISLPSREFKAGMAEIIKYGVISDLELFDLLERQENIADLSNIKEKLLLEIIKRSAKSKAEIVI
KDEKESGVRAFLNYGHTFGHVIENLCGYGKWLHGEAVAMGMVAVGQLAVQRGLWNEDNAKRQKRLIEKAGLPSNWPKLDI
ESVLSSLQGDKKVKNGKVSFVMPLKIGDVKLFNNISNKEIRECLQKIS

Sequences:

>Translated_368_residues
MNKDNHHIKVSLTNNPYEIVIGKNSLESIGDELFNIGFREGLKVLVVSNKEVSDHYGDCIIKSLIKSKFKPKLLIIKAGE
DQKNQSSIDLIHNAAYEARLERGSLMIALGGGVIGDMTGFAAATWLRGVNVVQIPTTLLAMVDASIGGKTGINHSKGKNL
IGAFHQPRLVLIDPKTLISLPSREFKAGMAEIIKYGVISDLELFDLLERQENIADLSNIKEKLLLEIIKRSAKSKAEIVI
KDEKESGVRAFLNYGHTFGHVIENLCGYGKWLHGEAVAMGMVAVGQLAVQRGLWNEDNAKRQKRLIEKAGLPSNWPKLDI
ESVLSSLQGDKKVKNGKVSFVMPLKIGDVKLFNNISNKEIRECLQKIS
>Mature_368_residues
MNKDNHHIKVSLTNNPYEIVIGKNSLESIGDELFNIGFREGLKVLVVSNKEVSDHYGDCIIKSLIKSKFKPKLLIIKAGE
DQKNQSSIDLIHNAAYEARLERGSLMIALGGGVIGDMTGFAAATWLRGVNVVQIPTTLLAMVDASIGGKTGINHSKGKNL
IGAFHQPRLVLIDPKTLISLPSREFKAGMAEIIKYGVISDLELFDLLERQENIADLSNIKEKLLLEIIKRSAKSKAEIVI
KDEKESGVRAFLNYGHTFGHVIENLCGYGKWLHGEAVAMGMVAVGQLAVQRGLWNEDNAKRQKRLIEKAGLPSNWPKLDI
ESVLSSLQGDKKVKNGKVSFVMPLKIGDVKLFNNISNKEIRECLQKIS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=347, Percent_Identity=40.0576368876081, Blast_Score=251, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6320332, Length=263, Percent_Identity=39.5437262357414, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_PROM1 (A2C1E0)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014565.1
- ProteinModelPortal:   A2C1E0
- SMR:   A2C1E0
- STRING:   A2C1E0
- GeneID:   4780370
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_07421
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   PMAR167555:NATL1_07421-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40602; Mature: 40602

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDNHHIKVSLTNNPYEIVIGKNSLESIGDELFNIGFREGLKVLVVSNKEVSDHYGDCI
CCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCHHCCCEEEEEECCCHHHHHHHHH
IKSLIKSKFKPKLLIIKAGEDQKNQSSIDLIHNAAYEARLERGSLMIALGGGVIGDMTGF
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
AAATWLRGVNVVQIPTTLLAMVDASIGGKTGINHSKGKNLIGAFHQPRLVLIDPKTLISL
HHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCEEEEECCHHHHHC
PSREFKAGMAEIIKYGVISDLELFDLLERQENIADLSNIKEKLLLEIIKRSAKSKAEIVI
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
KDEKESGVRAFLNYGHTFGHVIENLCGYGKWLHGEAVAMGMVAVGQLAVQRGLWNEDNAK
ECCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
RQKRLIEKAGLPSNWPKLDIESVLSSLQGDKKVKNGKVSFVMPLKIGDVKLFNNISNKEI
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHCCCCHHHH
RECLQKIS
HHHHHHCC
>Mature Secondary Structure
MNKDNHHIKVSLTNNPYEIVIGKNSLESIGDELFNIGFREGLKVLVVSNKEVSDHYGDCI
CCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHCCHHCCCEEEEEECCCHHHHHHHHH
IKSLIKSKFKPKLLIIKAGEDQKNQSSIDLIHNAAYEARLERGSLMIALGGGVIGDMTGF
HHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
AAATWLRGVNVVQIPTTLLAMVDASIGGKTGINHSKGKNLIGAFHQPRLVLIDPKTLISL
HHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCEEEEECCHHHHHC
PSREFKAGMAEIIKYGVISDLELFDLLERQENIADLSNIKEKLLLEIIKRSAKSKAEIVI
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
KDEKESGVRAFLNYGHTFGHVIENLCGYGKWLHGEAVAMGMVAVGQLAVQRGLWNEDNAK
ECCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
RQKRLIEKAGLPSNWPKLDIESVLSSLQGDKKVKNGKVSFVMPLKIGDVKLFNNISNKEI
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCHHHCCCCHHHH
RECLQKIS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA