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The map label for this gene is ugd [H]

Identifier: 124025392

GI number: 124025392

Start: 629904

End: 631307

Strand: Direct

Name: ugd [H]

Synonym: NATL1_06831

Alternate gene names: 124025392

Gene position: 629904-631307 (Clockwise)

Preceding gene: 124025391

Following gene: 124025393

Centisome position: 33.78

GC content: 35.54

Gene sequence:

>1404_bases
ATGAGCTCCATTAAAATCCAAAAAATATGTTGTATTGGCGCTGGTTATGTAGGTGGTCCAACCATGTCTGTTATTGCAGA
TAAATGTCCTGATTTAGAAATTAGGGTTGTTGATATCAATAAAGAACGAATAGATGCATGGAATGATTTAGATCTCAATA
AATTGCCAATATTTGAACCTGGATTAGATCGGATAATTTCAAGAACAAGAGGGCGGAACCTTTTCTTTAGCACAGAAATG
GAAAAGTCGATATCTGATGCTGATATGATTTTCATATCAGTCAATACTCCAACAAAAACAAAAGGTCTTGGAGCAGGACA
AGCAAGTGATCTTAGTTGGGTTGAAGCTAGTGCAAGGCAAGTCGCTAAATACGCAAAAGGTCACACGATAGTAATTGAAA
AAAGTACTCTTCCAGTTCGTACTGCACAGGCAATAAAAGAGATACTTAAGACAACAGATAAAGAGACGCAAAAAAATGAA
ATTTCAAAAACTTTTTCTGTTTTATCGAATCCTGAATTTTTGGCTGAAGGTACCGCAATTGATGACTTAGAAAAACCTGA
TAGGGTTTTAATTGGTGGAGAAGATTCTGACTCTATAGATGCACTGGTTAAGATTTATTTGAACTGGGTTCCTTATGAAC
AAATAATTTGTACTAATCTTTGGAGTAGCGAACTTTCAAAATTAGCTGCTAATGCATTCTTAGCTCAGAGAATTAGTTCC
ATCAATTCTATTTCAGCCTTTTGTGAGGCTACTGGAGCTGATGTTCAGGAAGTTGCTAAAGCAATAGGAACAGATAAAAG
GATTGGTAATCAATTTCTTAGTGCAGGTCCTGGGTTTGGTGGGAGCTGCTTTAAAAAGGATATTTTGAATTTAGTTTATT
TGAGTGGATATTTTGGATTACCAGAGGTTGCTAATTACTGGAATCAAGTTGTTGTGCTCAATACTTGGCAGCAAGATAGA
ATTTATAAAATTGTCCTAGAGAAGCTTTTTGGTACAGTTAATGGAAAAAATATAGCAATACTCGGTTTTTCTTTTAAGGC
AAACACCAACGATACCCGAGAATCACCTGCGATAAGAATTTCCAGTGACTTACTCGAAGAAGGAGCAATTTTATCAATTT
ATGACCCTAAGGTTACATTCGAGAGAATAGAAGAAGATTTTGAAAAATTTTCATTTAATAATCAAGGGATTTGGAAAATG
GCCACTTCTATTCCAGAAGCATTGAAAAATGTTGATGCAGTTATAATTCTTACTGCATGGGATGAATTCTTTGGACTTGA
TTGGAATTATTTAGCTTCTTTAATGAGATCACCAGCTTGGGTCTTTGATACCAGATCTGTTGTTAATCGACAAGAAGTTG
AAGATACAGGTGTAAATCTTTGGAAGCTGGGTGAGGGGAACTAA

Upstream 100 bases:

>100_bases
ACAAAAGGATGAGGAGAGTAGGGAATATATTTTCTCAAAGGGGGATCTAGATCAGTTAATTAAAAAGTTGATTGCTTAAA
AAAATGATGAATTATTTTAA

Downstream 100 bases:

>100_bases
AATATCTTCATAAAAAAAATAATATGCCTATAATTGATGCTTAAATAAATCTGATTGATTTTAAGTCTGTTATTAATTTA
ATTTTAGAAAAAATAATGCT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSSIKIQKICCIGAGYVGGPTMSVIADKCPDLEIRVVDINKERIDAWNDLDLNKLPIFEPGLDRIISRTRGRNLFFSTEM
EKSISDADMIFISVNTPTKTKGLGAGQASDLSWVEASARQVAKYAKGHTIVIEKSTLPVRTAQAIKEILKTTDKETQKNE
ISKTFSVLSNPEFLAEGTAIDDLEKPDRVLIGGEDSDSIDALVKIYLNWVPYEQIICTNLWSSELSKLAANAFLAQRISS
INSISAFCEATGADVQEVAKAIGTDKRIGNQFLSAGPGFGGSCFKKDILNLVYLSGYFGLPEVANYWNQVVVLNTWQQDR
IYKIVLEKLFGTVNGKNIAILGFSFKANTNDTRESPAIRISSDLLEEGAILSIYDPKVTFERIEEDFEKFSFNNQGIWKM
ATSIPEALKNVDAVIILTAWDEFFGLDWNYLASLMRSPAWVFDTRSVVNRQEVEDTGVNLWKLGEGN

Sequences:

>Translated_467_residues
MSSIKIQKICCIGAGYVGGPTMSVIADKCPDLEIRVVDINKERIDAWNDLDLNKLPIFEPGLDRIISRTRGRNLFFSTEM
EKSISDADMIFISVNTPTKTKGLGAGQASDLSWVEASARQVAKYAKGHTIVIEKSTLPVRTAQAIKEILKTTDKETQKNE
ISKTFSVLSNPEFLAEGTAIDDLEKPDRVLIGGEDSDSIDALVKIYLNWVPYEQIICTNLWSSELSKLAANAFLAQRISS
INSISAFCEATGADVQEVAKAIGTDKRIGNQFLSAGPGFGGSCFKKDILNLVYLSGYFGLPEVANYWNQVVVLNTWQQDR
IYKIVLEKLFGTVNGKNIAILGFSFKANTNDTRESPAIRISSDLLEEGAILSIYDPKVTFERIEEDFEKFSFNNQGIWKM
ATSIPEALKNVDAVIILTAWDEFFGLDWNYLASLMRSPAWVFDTRSVVNRQEVEDTGVNLWKLGEGN
>Mature_466_residues
SSIKIQKICCIGAGYVGGPTMSVIADKCPDLEIRVVDINKERIDAWNDLDLNKLPIFEPGLDRIISRTRGRNLFFSTEME
KSISDADMIFISVNTPTKTKGLGAGQASDLSWVEASARQVAKYAKGHTIVIEKSTLPVRTAQAIKEILKTTDKETQKNEI
SKTFSVLSNPEFLAEGTAIDDLEKPDRVLIGGEDSDSIDALVKIYLNWVPYEQIICTNLWSSELSKLAANAFLAQRISSI
NSISAFCEATGADVQEVAKAIGTDKRIGNQFLSAGPGFGGSCFKKDILNLVYLSGYFGLPEVANYWNQVVVLNTWQQDRI
YKIVLEKLFGTVNGKNIAILGFSFKANTNDTRESPAIRISSDLLEEGAILSIYDPKVTFERIEEDFEKFSFNNQGIWKMA
TSIPEALKNVDAVIILTAWDEFFGLDWNYLASLMRSPAWVFDTRSVVNRQEVEDTGVNLWKLGEGN

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=471, Percent_Identity=53.2908704883227, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI296040438, Length=373, Percent_Identity=51.4745308310992, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI296040443, Length=310, Percent_Identity=54.1935483870968, Blast_Score=319, Evalue=3e-87,
Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=27.2093023255814, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788340, Length=419, Percent_Identity=25.2983293556086, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560350, Length=467, Percent_Identity=52.4625267665953, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=52.4625267665953, Blast_Score=487, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51852; Mature: 51721

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIKIQKICCIGAGYVGGPTMSVIADKCPDLEIRVVDINKERIDAWNDLDLNKLPIFEP
CCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCCCCCCC
GLDRIISRTRGRNLFFSTEMEKSISDADMIFISVNTPTKTKGLGAGQASDLSWVEASARQ
CHHHHHHHHCCCCEEEECHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
VAKYAKGHTIVIEKSTLPVRTAQAIKEILKTTDKETQKNEISKTFSVLSNPEFLAEGTAI
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCCCC
DDLEKPDRVLIGGEDSDSIDALVKIYLNWVPYEQIICTNLWSSELSKLAANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSISAFCEATGADVQEVAKAIGTDKRIGNQFLSAGPGFGGSCFKKDILNLVYLSGYFGL
HHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
PEVANYWNQVVVLNTWQQDRIYKIVLEKLFGTVNGKNIAILGFSFKANTNDTRESPAIRI
HHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCEEE
SSDLLEEGAILSIYDPKVTFERIEEDFEKFSFNNQGIWKMATSIPEALKNVDAVIILTAW
EHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEC
DEFFGLDWNYLASLMRSPAWVFDTRSVVNRQEVEDTGVNLWKLGEGN
HHHHCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure 
SSIKIQKICCIGAGYVGGPTMSVIADKCPDLEIRVVDINKERIDAWNDLDLNKLPIFEP
CCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCCCCCCC
GLDRIISRTRGRNLFFSTEMEKSISDADMIFISVNTPTKTKGLGAGQASDLSWVEASARQ
CHHHHHHHHCCCCEEEECHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
VAKYAKGHTIVIEKSTLPVRTAQAIKEILKTTDKETQKNEISKTFSVLSNPEFLAEGTAI
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHCCCCCC
DDLEKPDRVLIGGEDSDSIDALVKIYLNWVPYEQIICTNLWSSELSKLAANAFLAQRISS
CCCCCCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INSISAFCEATGADVQEVAKAIGTDKRIGNQFLSAGPGFGGSCFKKDILNLVYLSGYFGL
HHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
PEVANYWNQVVVLNTWQQDRIYKIVLEKLFGTVNGKNIAILGFSFKANTNDTRESPAIRI
HHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCEEE
SSDLLEEGAILSIYDPKVTFERIEEDFEKFSFNNQGIWKMATSIPEALKNVDAVIILTAW
EHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEC
DEFFGLDWNYLASLMRSPAWVFDTRSVVNRQEVEDTGVNLWKLGEGN
HHHHCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]