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The map label for this gene is hisG

Identifier: 124025326

GI number: 124025326

Start: 558223

End: 558885

Strand: Direct

Name: hisG

Synonym: NATL1_06151

Alternate gene names: 124025326

Gene position: 558223-558885 (Clockwise)

Preceding gene: 124025322

Following gene: 124025327

Centisome position: 29.94

GC content: 39.82

Gene sequence:

>663_bases
ATGTTTACTGTTGCATTAGCTAAAGGTGCCTTATTGCAAGAATCAGTCTCAATGTTTTCTGACGTTGGACTTGATTTCTC
TGCTGTTTTAGACGATAGCAATCGGCAATTAATGGTTCCGTCAGCTTGTGGCCGTGCTAAAGCTCTTTTGGTTAGGAATA
GCGATGTTCCTGTTTACGTATCTTATGGTCAGGCGCAACTAGGAATAGTGGGTTTTGATGTATTACAAGAGCAAAAATTA
CAAGTTTCTAATTTAGTTGACCTTGGATTTGGAGAGTGTCATATGTCGGTTGCAGTTAAATCCAGCAGTGGTTATTTGAG
TGCTTCTGATCTACCACCAAACTGTCGCGTGGCAAGTAAATTTACTAACTGCGCAAAGCATTTTTTTGATCAAATTGATT
TGCCCGTTCAATTGGTACATTTGAGTGGATCTGTTGAACTGGGTCCCATAACGGGTATGGCTGAAGCAATCGTTGATTTA
GTCGCAACTGGTCGTACTCTTAGAGATAATGGTCTTGTAGAAATTGAAGAACTTTTTAAATCAAGTGCTCGGCTTGTCGG
TCATCCACTATCCCTGAGACTTGATAAAGGGCCACTTCAAGAAATTATTGATTCAATTCAAATCCAATCTCAGACAAACC
TCCTTTCTGATGGCAAAAAATGA

Upstream 100 bases:

>100_bases
TGTAAGACATTAATTGGGTGAATAGTGAAGTCGCTTTTTTCCCCTAACATTGTTTCTTTAGGTAATGGAGTAATTAGAGT
CCATTTCAAGAGTTTTTGAC

Downstream 100 bases:

>100_bases
TTTTCGAAGAATTAAGAAACTTGGAAAGTATTTAAAAAGAGAAAAAAAACGTTTAATTCTCATACTTTTAATATTAATAC
CTGTTGCATTAGCTGGTTCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MFTVALAKGALLQESVSMFSDVGLDFSAVLDDSNRQLMVPSACGRAKALLVRNSDVPVYVSYGQAQLGIVGFDVLQEQKL
QVSNLVDLGFGECHMSVAVKSSSGYLSASDLPPNCRVASKFTNCAKHFFDQIDLPVQLVHLSGSVELGPITGMAEAIVDL
VATGRTLRDNGLVEIEELFKSSARLVGHPLSLRLDKGPLQEIIDSIQIQSQTNLLSDGKK

Sequences:

>Translated_220_residues
MFTVALAKGALLQESVSMFSDVGLDFSAVLDDSNRQLMVPSACGRAKALLVRNSDVPVYVSYGQAQLGIVGFDVLQEQKL
QVSNLVDLGFGECHMSVAVKSSSGYLSASDLPPNCRVASKFTNCAKHFFDQIDLPVQLVHLSGSVELGPITGMAEAIVDL
VATGRTLRDNGLVEIEELFKSSARLVGHPLSLRLDKGPLQEIIDSIQIQSQTNLLSDGKK
>Mature_220_residues
MFTVALAKGALLQESVSMFSDVGLDFSAVLDDSNRQLMVPSACGRAKALLVRNSDVPVYVSYGQAQLGIVGFDVLQEQKL
QVSNLVDLGFGECHMSVAVKSSSGYLSASDLPPNCRVASKFTNCAKHFFDQIDLPVQLVHLSGSVELGPITGMAEAIVDL
VATGRTLRDNGLVEIEELFKSSARLVGHPLSLRLDKGPLQEIIDSIQIQSQTNLLSDGKK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=172, Percent_Identity=33.7209302325581, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.8108108108108, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PROM1 (A2C117)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014442.1
- ProteinModelPortal:   A2C117
- SMR:   A2C117
- STRING:   A2C117
- GeneID:   4779596
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_06151
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   PMAR167555:NATL1_06151-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23607; Mature: 23607

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVALAKGALLQESVSMFSDVGLDFSAVLDDSNRQLMVPSACGRAKALLVRNSDVPVYV
CEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEEEECCCCCEEE
SYGQAQLGIVGFDVLQEQKLQVSNLVDLGFGECHMSVAVKSSSGYLSASDLPPNCRVASK
ECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEECCCCCCCHHHHH
FTNCAKHFFDQIDLPVQLVHLSGSVELGPITGMAEAIVDLVATGRTLRDNGLVEIEELFK
HHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHCCCEECCCCCCHHHHHHH
SSARLVGHPLSLRLDKGPLQEIIDSIQIQSQTNLLSDGKK
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFTVALAKGALLQESVSMFSDVGLDFSAVLDDSNRQLMVPSACGRAKALLVRNSDVPVYV
CEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEEEECCCCCEEE
SYGQAQLGIVGFDVLQEQKLQVSNLVDLGFGECHMSVAVKSSSGYLSASDLPPNCRVASK
ECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEECCCCCCCHHHHH
FTNCAKHFFDQIDLPVQLVHLSGSVELGPITGMAEAIVDLVATGRTLRDNGLVEIEELFK
HHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHCCCEECCCCCCHHHHHHH
SSARLVGHPLSLRLDKGPLQEIIDSIQIQSQTNLLSDGKK
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA