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The map label for this gene is hemC

Identifier: 124025263

GI number: 124025263

Start: 499840

End: 500787

Strand: Reverse

Name: hemC

Synonym: NATL1_05521

Alternate gene names: 124025263

Gene position: 500787-499840 (Counterclockwise)

Preceding gene: 124025264

Following gene: 124025260

Centisome position: 26.86

GC content: 40.61

Gene sequence:

>948_bases
ATGACACTAGACCAACTGCGCATCGCCTCTCGCCGAAGCCAGCTGGCCATGGTTCAGACGAACTGGGTACGAGATGAACT
ACAAAGAGCACATCCTGATCTTGCTATAACTATCGAAGCAATGGCAACGCAGGGTGACAAAATACTTGATGTGGCTTTAG
CAAAAATAGGAGATAAAGGTCTTTTCACTAAAGAGCTTGAAGCTCAAATGCTTCTTGGTCATGCTGAAATTGCAGTCCAC
TCACTTAAGGATTTACCCACGAACCTTCCAGAGGGATTGATTCTTGGCTGCATCACAGAAAGAGAAGATCCTTCAGACGC
GTTAGTCGTTAATGAGAAAAATCAAATTCACAAACTAGAGACTCTGCCAGAAGGTTCTGTAGTGGGGACTAGTTCATTAA
GAAGGCTTGCTCAATTGAGATACCATTATCCACATCTTGTTTTCAAAGATGTAAGAGGAAATGTTATTACACGATTAGAA
AAGCTTGACTCAGGAGAATATGACTGTCTTATCTTGGCTGCTGCTGGATTGCAAAGACTTGGTTTTGCTAATCGAATACA
TCAATTAATCCCAACAGATATTTCACTCCATGCTGTGGGGCAGGGAGCTCTTGGTATTGAATGTGTAAGTGGTCAGCAAA
AGGTACTAGATATTTTAAAAACACTTGAACACGAATCAACATCTAAAAGATGTTTAGCTGAAAGGTCTTTCCTCAGAGAG
CTTGAAGGAGGATGTCAAGTTCCAATAGGCGTTAGAACGGAAATTAACAACAATGAATTAATTCTTGAAGGAATGGTCGC
AAGTTTAGATGGTAAAAGATTAATTAGAGATATAAAAAAAGGATCGGTAAGCTCTGCGGAGGAAATAGGAATAGACTTAG
CCAATGAATTAAAAGGCCGTGGAGCAGGGGAAATATTAGAAGAGATATTCAAGTCTGCAAGGGCCTAA

Upstream 100 bases:

>100_bases
CATAGATTTCATTTCACATCAACCTTATTAAATTATTTTCCAAGATTTTTAATTTGGTAAGGTTGACTGCTTAAGGTAAA
GAAATAGAAAATATTTGCTA

Downstream 100 bases:

>100_bases
ATCATTCATAAAATTTAATTAATTAAATTAGGATCTATTTCAGATAAGTAACGCTCCTCACAGGATTTAATAATCTGAAC
TGCTTTTTCAACACCAAAGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTLDQLRIASRRSQLAMVQTNWVRDELQRAHPDLAITIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLLGHAEIAVH
SLKDLPTNLPEGLILGCITEREDPSDALVVNEKNQIHKLETLPEGSVVGTSSLRRLAQLRYHYPHLVFKDVRGNVITRLE
KLDSGEYDCLILAAAGLQRLGFANRIHQLIPTDISLHAVGQGALGIECVSGQQKVLDILKTLEHESTSKRCLAERSFLRE
LEGGCQVPIGVRTEINNNELILEGMVASLDGKRLIRDIKKGSVSSAEEIGIDLANELKGRGAGEILEEIFKSARA

Sequences:

>Translated_315_residues
MTLDQLRIASRRSQLAMVQTNWVRDELQRAHPDLAITIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLLGHAEIAVH
SLKDLPTNLPEGLILGCITEREDPSDALVVNEKNQIHKLETLPEGSVVGTSSLRRLAQLRYHYPHLVFKDVRGNVITRLE
KLDSGEYDCLILAAAGLQRLGFANRIHQLIPTDISLHAVGQGALGIECVSGQQKVLDILKTLEHESTSKRCLAERSFLRE
LEGGCQVPIGVRTEINNNELILEGMVASLDGKRLIRDIKKGSVSSAEEIGIDLANELKGRGAGEILEEIFKSARA
>Mature_314_residues
TLDQLRIASRRSQLAMVQTNWVRDELQRAHPDLAITIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLLGHAEIAVHS
LKDLPTNLPEGLILGCITEREDPSDALVVNEKNQIHKLETLPEGSVVGTSSLRRLAQLRYHYPHLVFKDVRGNVITRLEK
LDSGEYDCLILAAAGLQRLGFANRIHQLIPTDISLHAVGQGALGIECVSGQQKVLDILKTLEHESTSKRCLAERSFLREL
EGGCQVPIGVRTEINNNELILEGMVASLDGKRLIRDIKKGSVSSAEEIGIDLANELKGRGAGEILEEIFKSARA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=46.6867469879518, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=46.6867469879518, Blast_Score=281, Evalue=5e-76,
Organism=Escherichia coli, GI48994974, Length=306, Percent_Identity=50.6535947712418, Blast_Score=297, Evalue=6e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=325, Percent_Identity=42.7692307692308, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=48.2394366197183, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_PROM1 (A2C0V4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014379.1
- ProteinModelPortal:   A2C0V4
- SMR:   A2C0V4
- STRING:   A2C0V4
- GeneID:   4780319
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_05521
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   PMAR167555:NATL1_05521-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 34598; Mature: 34467

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDQLRIASRRSQLAMVQTNWVRDELQRAHPDLAITIEAMATQGDKILDVALAKIGDKG
CCHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLLGHAEIAVHSLKDLPTNLPEGLILGCITEREDPSDALVVNEKNQIHKLE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHH
TLPEGSVVGTSSLRRLAQLRYHYPHLVFKDVRGNVITRLEKLDSGEYDCLILAAAGLQRL
CCCCCCEECHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHH
GFANRIHQLIPTDISLHAVGQGALGIECVSGQQKVLDILKTLEHESTSKRCLAERSFLRE
HHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIGVRTEINNNELILEGMVASLDGKRLIRDIKKGSVSSAEEIGIDLANELKGR
HCCCCCCCEEEEEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCC
GAGEILEEIFKSARA
CHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLDQLRIASRRSQLAMVQTNWVRDELQRAHPDLAITIEAMATQGDKILDVALAKIGDKG
CHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLLGHAEIAVHSLKDLPTNLPEGLILGCITEREDPSDALVVNEKNQIHKLE
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHH
TLPEGSVVGTSSLRRLAQLRYHYPHLVFKDVRGNVITRLEKLDSGEYDCLILAAAGLQRL
CCCCCCEECHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHH
GFANRIHQLIPTDISLHAVGQGALGIECVSGQQKVLDILKTLEHESTSKRCLAERSFLRE
HHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LEGGCQVPIGVRTEINNNELILEGMVASLDGKRLIRDIKKGSVSSAEEIGIDLANELKGR
HCCCCCCCEEEEEECCCCEEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCC
GAGEILEEIFKSARA
CHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA