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The map label for this gene is srpG [H]

Identifier: 124025171

GI number: 124025171

Start: 419750

End: 420736

Strand: Reverse

Name: srpG [H]

Synonym: NATL1_04581

Alternate gene names: 124025171

Gene position: 420736-419750 (Counterclockwise)

Preceding gene: 124025172

Following gene: 124025165

Centisome position: 22.56

GC content: 42.05

Gene sequence:

>987_bases
ATGTCCAGAATCTATGAAGACAATAGTTTCGCTATTGGTCATACCCCATTAGTCAAGCTTAATTCAATTACAAAAAACGC
AAAAGCAACAGTATTGGCAAAGATAGAAGGCCGTAACCCCGCCTACAGCGTTAAGTGCAGAATAGGAGCGAACATGATCT
GGGATGCTGAGAAGAAAGGTTTACTCAATAAAGATAAAGTCATTATTGAACCAACTTCTGGAAATACTGGAATAGCCCTT
GCTTACACAGCTGCTGCTCGAGGTTACAAGTTAATCCTCACGATGCCTGAGTCCATGTCAATTGAACGTCGGAGGATGAT
GGCTGTTCTTGGTGCTGAATTAATACTAACTGAAGCAGCAAAAGGAATGCCTGGTGCCATTGCAAAAGCGAAGGAGATAG
CTGATGGCGACCCTCAAAAATACTTCATGCCAGGCCAATTTGATAATCCAGCTAATCCAGAAATACATTTCAAAACAACA
GGTCCTGAAATTTGGGATGATACCGATGGCCAAATTGATGTTTTAGTCTCTGGCGTCGGGACAGGTGGAACAATAACAGG
TGTCTCTCGTTTTATAAAACAAGAAAAAAATCATTCATTATTATCTGTTGCCGTTGAGCCCACTCATAGCCCAGTAATAA
CACAAACTCTCAATGGAGAAGAGGTAAAGCCCGGCCCTCACAAGATTCAAGGGATCGGAGCTGGGTTTATCCCTAAAAAT
CTTGACTTATCAGTAGTCGATCAAGTTGAGCAAGTCTCTAATGATGAGTCTATTGCAATGGCATTACGTTTAGCACAAGA
AGAAGGTCTACTAGTTGGAATCTCATGTGGTGCCGCTGCAGCTGTGGCTTTAAGACTTGCCGAAAAAGAAGAGTTCGCAG
GGAAGACAATCGTTGTGGTTCTTCCTGACCTTGCAGAAAGATATATCTCATCCGTAATGTTTGAGAATGTTCCTACAGGC
GTTATTAAAGAACCATCATTAGCTTGA

Upstream 100 bases:

>100_bases
TCAGTAATATAAAAAAATCACTAATAAAGATTATCTAAACAACCAATTACCGAGATTTTTATATAGATTTAGAGTATTAG
TTAATTAAGTCATTTAAAAA

Downstream 100 bases:

>100_bases
CTTTTGAGTTTAAATAACCGACTCAGGTGTTATTAACATCGCATCTCCATAAGAGAAAAATCGATATTTGTTAGAGATAG
CATGTTTATAAAGTTTCAAC

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSRIYEDNSFAIGHTPLVKLNSITKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKKGLLNKDKVIIEPTSGNTGIAL
AYTAAARGYKLILTMPESMSIERRRMMAVLGAELILTEAAKGMPGAIAKAKEIADGDPQKYFMPGQFDNPANPEIHFKTT
GPEIWDDTDGQIDVLVSGVGTGGTITGVSRFIKQEKNHSLLSVAVEPTHSPVITQTLNGEEVKPGPHKIQGIGAGFIPKN
LDLSVVDQVEQVSNDESIAMALRLAQEEGLLVGISCGAAAAVALRLAEKEEFAGKTIVVVLPDLAERYISSVMFENVPTG
VIKEPSLA

Sequences:

>Translated_328_residues
MSRIYEDNSFAIGHTPLVKLNSITKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKKGLLNKDKVIIEPTSGNTGIAL
AYTAAARGYKLILTMPESMSIERRRMMAVLGAELILTEAAKGMPGAIAKAKEIADGDPQKYFMPGQFDNPANPEIHFKTT
GPEIWDDTDGQIDVLVSGVGTGGTITGVSRFIKQEKNHSLLSVAVEPTHSPVITQTLNGEEVKPGPHKIQGIGAGFIPKN
LDLSVVDQVEQVSNDESIAMALRLAQEEGLLVGISCGAAAAVALRLAEKEEFAGKTIVVVLPDLAERYISSVMFENVPTG
VIKEPSLA
>Mature_327_residues
SRIYEDNSFAIGHTPLVKLNSITKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKKGLLNKDKVIIEPTSGNTGIALA
YTAAARGYKLILTMPESMSIERRRMMAVLGAELILTEAAKGMPGAIAKAKEIADGDPQKYFMPGQFDNPANPEIHFKTTG
PEIWDDTDGQIDVLVSGVGTGGTITGVSRFIKQEKNHSLLSVAVEPTHSPVITQTLNGEEVKPGPHKIQGIGAGFIPKNL
DLSVVDQVEQVSNDESIAMALRLAQEEGLLVGISCGAAAAVALRLAEKEEFAGKTIVVVLPDLAERYISSVMFENVPTGV
IKEPSLA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=332, Percent_Identity=38.5542168674699, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI295821200, Length=332, Percent_Identity=38.5542168674699, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4557415, Length=332, Percent_Identity=38.5542168674699, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=65.625, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=41.9141914191419, Blast_Score=204, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=317, Percent_Identity=51.4195583596215, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI115535073, Length=316, Percent_Identity=50.9493670886076, Blast_Score=270, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17562970, Length=320, Percent_Identity=44.6875, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=45.5128205128205, Blast_Score=263, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17561720, Length=328, Percent_Identity=44.8170731707317, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=43.4977578475336, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=323, Percent_Identity=38.6996904024768, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=38.4615384615385, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=136, Percent_Identity=38.2352941176471, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=34.2857142857143, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=33.1288343558282, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=40.8360128617363, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=40.8360128617363, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35062; Mature: 34931

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIYEDNSFAIGHTPLVKLNSITKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKKG
CCCEECCCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCHHCC
LLNKDKVIIEPTSGNTGIALAYTAAARGYKLILTMPESMSIERRRMMAVLGAELILTEAA
CCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
KGMPGAIAKAKEIADGDPQKYFMPGQFDNPANPEIHFKTTGPEIWDDTDGQIDVLVSGVG
CCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEECC
TGGTITGVSRFIKQEKNHSLLSVAVEPTHSPVITQTLNGEEVKPGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCC
LDLSVVDQVEQVSNDESIAMALRLAQEEGLLVGISCGAAAAVALRLAEKEEFAGKTIVVV
CCHHHHHHHHHHCCCCHHHHHEEHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEE
LPDLAERYISSVMFENVPTGVIKEPSLA
CCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRIYEDNSFAIGHTPLVKLNSITKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKKG
CCEECCCCEEECCCCEEEEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEECCHHCC
LLNKDKVIIEPTSGNTGIALAYTAAARGYKLILTMPESMSIERRRMMAVLGAELILTEAA
CCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
KGMPGAIAKAKEIADGDPQKYFMPGQFDNPANPEIHFKTTGPEIWDDTDGQIDVLVSGVG
CCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEECC
TGGTITGVSRFIKQEKNHSLLSVAVEPTHSPVITQTLNGEEVKPGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCC
LDLSVVDQVEQVSNDESIAMALRLAQEEGLLVGISCGAAAAVALRLAEKEEFAGKTIVVV
CCHHHHHHHHHHCCCCHHHHHEEHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEE
LPDLAERYISSVMFENVPTGVIKEPSLA
CCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]