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The map label for this gene is ctaB

Identifier: 124022355

GI number: 124022355

Start: 607953

End: 608954

Strand: Direct

Name: ctaB

Synonym: P9303_06451

Alternate gene names: 124022355

Gene position: 607953-608954 (Clockwise)

Preceding gene: 124022354

Following gene: 124022356

Centisome position: 22.66

GC content: 56.19

Gene sequence:

>1002_bases
ATGGTTAGTTCAACGCCAGAGATGCTCCAGGGGGGGCTTACCCGTGAGCAGATCGTGCCTTCTCGCAAGCGGATCAAGCT
GCCAGCTTGGTTGGAGATTGCCAAACCACGCTTAATTCCACTGCTTTTGGCCACAACCCTTGGTGGGATGGCGCTATCCG
AAGGTTGGCCCCTACCTTCTCTCAGACTGGCCTGCACCCTAGGAGGAGGGGCTCTGGCTGCTGCTGCTGCTGGTGTTCTC
AACTGCATTTGGGAACAGGATCTTGATGGGCGCATGCAACGCACAAGTGGTAGGGCTTTGCCTTCAGGACGCTTGTCTCC
AACTGCGGCGTTCATCGGTGCCATCTCTTGCACCTTGGCGGCAGCGGCTCTGTTGGTAAGTGGTGTGAACTGTCTTGCGG
CTGGCCTGTCTTTGCTTGGTCTGTGCAGTTACGTGCTGCTTTACACGGCAATCTTGAAGCCCCGCACTCCCCAAAACATT
GTCATTGGAGGGGTTGCTGGAGCGATCCCCCCTCTCGTGGGTGCGGCTGCGGCCAGTGGGCATGTGGGCCTTAGTGGATG
GTGGTTGTTTGCCCTGGTCATGCTTTGGACCCCAGCGCATTTTTGGGCACTGGCCCTGTTGCTGCGAGACGACTACAGGG
CTGTTGGGATACCCATGCTTCCTGTCGTTAAGGGCCCTGTGGTCACCGTCAGAGCCATTTCTCGTTATGGCTGGGCCACG
GTTCTACTCAGCGGTTTTGGTGTCTGGGCCTTGCCGGAGGGGGGCTTGCTCTACGGACTTTTGTTGATCCCTTTCAATGC
TCGTCTGCTGCAAATGGTTCATCAGCTAGGTGCTGCTCCGGAGAATGTTGATCGAGCCAAGGGGCTCTTCCGTTGGTCGA
TCTTCTATATGTTTGGTATCTGCCTTCTTCTGGTGGTTAGTCGTTTGCCTATGGCGGCTAATTTTGATCTTCAGGCCTGG
TCTTTGCTTCAGCAGATGGCGAGCAGTGGGCAGTTCATCTAA

Upstream 100 bases:

>100_bases
CTGCTTGTGGCCTTGCTTGCCGCCCTTACCTTCCGTAATCCGGAAGGATCACCTTTGGTGGTGTCTGCCGTTGGTGATGC
ATCCTCGATAGACCATTGTC

Downstream 100 bases:

>100_bases
ACAGAAGTCACTAGAGACCCCCTGGAGGGTCTGGTAGCTCTATAGAGCTGCCTAGATTTTTAAGACTTGTACGACGTTCC
CTCTTGATGCCGATGATTGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVSSTPEMLQGGLTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFALVMLWTPAHFWALALLLRDDYRAVGIPMLPVVKGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI

Sequences:

>Translated_333_residues
MVSSTPEMLQGGLTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFALVMLWTPAHFWALALLLRDDYRAVGIPMLPVVKGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI
>Mature_333_residues
MVSSTPEMLQGGLTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPSLRLACTLGGGALAAAAAGVL
NCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNI
VIGGVAGAIPPLVGAAAASGHVGLSGWWLFALVMLWTPAHFWALALLLRDDYRAVGIPMLPVVKGPVVTVRAISRYGWAT
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGICLLLVVSRLPMAANFDLQAW
SLLQQMASSGQFI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=196, Percent_Identity=35.2040816326531, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1786631, Length=207, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71998235, Length=264, Percent_Identity=29.5454545454545, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=216, Percent_Identity=31.0185185185185, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921064, Length=282, Percent_Identity=30.8510638297872, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_PROM3 (A2C7D7)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016662.1
- STRING:   A2C7D7
- GeneID:   4778802
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_06451
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEGW
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35316; Mature: 35316

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x150032f8)-; HASH(0x15013388)-; HASH(0x1500a3c0)-; HASH(0x1501355c)-; HASH(0x15016404)-; HASH(0x1500a660)-; HASH(0x15016248)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSTPEMLQGGLTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPS
CCCCCHHHHHCCCCHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCC
LRLACTLGGGALAAAAAGVLNCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLA
EEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNIVIGGVAGAIPPLVGAAAASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCC
HVGLSGWWLFALVMLWTPAHFWALALLLRDDYRAVGIPMLPVVKGPVVTVRAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGI
HHHHCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
CLLLVVSRLPMAANFDLQAWSLLQQMASSGQFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MVSSTPEMLQGGLTREQIVPSRKRIKLPAWLEIAKPRLIPLLLATTLGGMALSEGWPLPS
CCCCCHHHHHCCCCHHHHCCCHHHCCCCHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCC
LRLACTLGGGALAAAAAGVLNCIWEQDLDGRMQRTSGRALPSGRLSPTAAFIGAISCTLA
EEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AAALLVSGVNCLAAGLSLLGLCSYVLLYTAILKPRTPQNIVIGGVAGAIPPLVGAAAASG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHCCC
HVGLSGWWLFALVMLWTPAHFWALALLLRDDYRAVGIPMLPVVKGPVVTVRAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VLLSGFGVWALPEGGLLYGLLLIPFNARLLQMVHQLGAAPENVDRAKGLFRWSIFYMFGI
HHHHCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
CLLLVVSRLPMAANFDLQAWSLLQQMASSGQFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA