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The map label for this gene is nagB [H]

Identifier: 124022246

GI number: 124022246

Start: 519729

End: 520553

Strand: Direct

Name: nagB [H]

Synonym: P9303_05361

Alternate gene names: 124022246

Gene position: 519729-520553 (Clockwise)

Preceding gene: 124022245

Following gene: 124022247

Centisome position: 19.37

GC content: 56.0

Gene sequence:

>825_bases
TTGAACCTCTTGCGGCCTTCTGTGGCCTCTGAGCAAGGGTTCGCAAGCACGATCACGGTGCGAGAGAACCTGCCAAGCCT
TGTGGAAGCGGTTGTTGATGCGCTGGAGGGGCATCTAAGGCAGCGGCTGGGGGAGCAGAGGCCGAAACCGCTTGGCTTGG
CCACTGGCCGCACGATGGTGCCGATCTATGCCGCACTGGTGGCCCGTGTGCAGCGTTGGCCAGCTGATGAGCTGGAGCAT
CTGCGGCGCAGTTGGTGCAGCTTCAATCTCGATGAGTATGTGGGCTTGGGGGCAGCTGATCGGCGCAGCTTTGCGGCCTA
TATGGCGCGTCATGTAGGCAAGCCGTTGCAATTGAGCCCGCAGCAGTTGCATCTTCCCGATGGCGAGGCGATTAATCCAG
TACAGCAGGCTGGCAGTTATGCCGCTCAGTTGCAGAGTTTTGGTGGTGTTGGTGTGCAGTTGTTGGGCTTAGGCAGCAAT
GGCCATGTGGGCTTCAATGAGCCGCCTTGTGGCCCAGAGGCGTCTTGCCGGGTGGTGTCGTTATCGCAGTCCACTCGGCA
ACAGAATGCAGCTGCTTTTGGTGGTGATCCCAGTCAGGTGCCATCTCAATCATTCACGCTTGGATTAAAAGAAATACTCG
CGGCAGATGAGATTCATCTGATCGTGACGGGTTCAGCTAAAGCAGAGATTCTTAAGAAGTTGCTTAATTCGCCATGCACG
GATCAGTTGCCGGCAAGTTGGTTGCGCAATCATCCTCGGGTTTCACTTTGGGCAGATCAAGCAGCTGTTAATGGAGAGAT
CGTTGCTGAAGCGAAGCTCAGTTAA

Upstream 100 bases:

>100_bases
CGCAGAGATTGTTCCCTATCGGCAGCTGCAGAATTCCTCTTTGGCCTTCCTGTGGCGCTCTCGCCAGCCTGGAGGAGTTG
AGAGAATGGGAGGCGCCTAA

Downstream 100 bases:

>100_bases
AAGTTGATTGGCGTTTTTGGTCTTTCTTTCTTTCTTGCAAGAAAATCACTAGTGATAGCAGGTAATTAATCACGCCTCAG
CAAGGCGATACTGGCATAGT

Product: 6-phosphogluconolactonase/glucosamine-6- phosphate isomerase/deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYAALVARVQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHVGKPLQLSPQQLHLPDGEAINPVQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEASCRVVSLSQSTRQQNAAAFGGDPSQVPSQSFTLGLKEILAADEIHLIVTGSAKAEILKKLLNSPCT
DQLPASWLRNHPRVSLWADQAAVNGEIVAEAKLS

Sequences:

>Translated_274_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYAALVARVQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHVGKPLQLSPQQLHLPDGEAINPVQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEASCRVVSLSQSTRQQNAAAFGGDPSQVPSQSFTLGLKEILAADEIHLIVTGSAKAEILKKLLNSPCT
DQLPASWLRNHPRVSLWADQAAVNGEIVAEAKLS
>Mature_274_residues
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMVPIYAALVARVQRWPADELEH
LRRSWCSFNLDEYVGLGAADRRSFAAYMARHVGKPLQLSPQQLHLPDGEAINPVQQAGSYAAQLQSFGGVGVQLLGLGSN
GHVGFNEPPCGPEASCRVVSLSQSTRQQNAAAFGGDPSQVPSQSFTLGLKEILAADEIHLIVTGSAKAEILKKLLNSPCT
DQLPASWLRNHPRVSLWADQAAVNGEIVAEAKLS

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=221, Percent_Identity=29.8642533936652, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI13027378, Length=231, Percent_Identity=28.1385281385281, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786893, Length=215, Percent_Identity=29.7674418604651, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789530, Length=209, Percent_Identity=32.0574162679426, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI48994958, Length=109, Percent_Identity=35.7798165137615, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554876, Length=212, Percent_Identity=28.7735849056604, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24581960, Length=230, Percent_Identity=28.2608695652174, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19920764, Length=230, Percent_Identity=28.2608695652174, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 29423; Mature: 29423

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMV
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
PIYAALVARVQRWPADELEHLRRSWCSFNLDEYVGLGAADRRSFAAYMARHVGKPLQLSP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
QQLHLPDGEAINPVQQAGSYAAQLQSFGGVGVQLLGLGSNGHVGFNEPPCGPEASCRVVS
CEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
LSQSTRQQNAAAFGGDPSQVPSQSFTLGLKEILAADEIHLIVTGSAKAEILKKLLNSPCT
CCHHHHHHCCHHCCCCHHHCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
DQLPASWLRNHPRVSLWADQAAVNGEIVAEAKLS
CCCCHHHHHCCCCEEEEECCHHCCCCEEEEECCC
>Mature Secondary Structure
MNLLRPSVASEQGFASTITVRENLPSLVEAVVDALEGHLRQRLGEQRPKPLGLATGRTMV
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
PIYAALVARVQRWPADELEHLRRSWCSFNLDEYVGLGAADRRSFAAYMARHVGKPLQLSP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
QQLHLPDGEAINPVQQAGSYAAQLQSFGGVGVQLLGLGSNGHVGFNEPPCGPEASCRVVS
CEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
LSQSTRQQNAAAFGGDPSQVPSQSFTLGLKEILAADEIHLIVTGSAKAEILKKLLNSPCT
CCHHHHHHCCHHCCCCHHHCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCC
DQLPASWLRNHPRVSLWADQAAVNGEIVAEAKLS
CCCCHHHHHCCCCEEEEECCHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]