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The map label for this gene is apt

Identifier: 123968763

GI number: 123968763

Start: 1047827

End: 1048339

Strand: Reverse

Name: apt

Synonym: A9601_12301

Alternate gene names: 123968763

Gene position: 1048339-1047827 (Counterclockwise)

Preceding gene: 123968766

Following gene: 123968761

Centisome position: 62.78

GC content: 30.8

Gene sequence:

>513_bases
ATGAAAAAATTAGAAGATTTGATTCTCACTTATAAGGATTTTCCAAAAAAAGGGATTGAATTTAAGGACGTTCTCGAAAT
TCTTCAATATCCAGATATTTTTCAGGACATAATTTTAAAAATGTCTTCAAATCAATTCCTAAAAAAAGCTGAAGCAATAA
TTTCCATAGATGCGAGGGGATTTATTTTTGGTTCAGCAGTTGCTCTAGAATCATCTAAACCTATGATTGTGGCACGTAAA
CCTGGGAAACTACCAGGACAGTTATTAACAAGAGAATATGATTTGGAATATGGGAAAAATTCTCTTTCAATACAAGTTAA
TGCCCTGAAAAAATTTAATTCTTTTGTAATCGTAGATGATTTATTAGCTACAGGAGGAACAGTTAAATCTGTATCAAGGT
TGATTCGTGATCAAAAGAAGAAAATATTGGGATTAATAACTGTTGTTGAATTGAAGAGTTTAAAAGGCAAATCTAAGTTG
GATTTTCCAGTACACTCAATAGTTACCTTATAG

Upstream 100 bases:

>100_bases
TATTAGTTCGCTTTGAAATGTTTTTAATTTACGACATATTAAAAATGTGAATTGAAATCCATAAGGATATCCATCTGAAT
TGCTTTTGAGAATTTGAAGT

Downstream 100 bases:

>100_bases
AATCACAAAAGTGGAATTTTAAAAAAAGTATCTATTAGTGAGCTTTAGTAATTTGTCTATCAAGTAGAAAATTTTTAGTT
TTTAGTAAAAATTTGAGAGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MKKLEDLILTYKDFPKKGIEFKDVLEILQYPDIFQDIILKMSSNQFLKKAEAIISIDARGFIFGSAVALESSKPMIVARK
PGKLPGQLLTREYDLEYGKNSLSIQVNALKKFNSFVIVDDLLATGGTVKSVSRLIRDQKKKILGLITVVELKSLKGKSKL
DFPVHSIVTL

Sequences:

>Translated_170_residues
MKKLEDLILTYKDFPKKGIEFKDVLEILQYPDIFQDIILKMSSNQFLKKAEAIISIDARGFIFGSAVALESSKPMIVARK
PGKLPGQLLTREYDLEYGKNSLSIQVNALKKFNSFVIVDDLLATGGTVKSVSRLIRDQKKKILGLITVVELKSLKGKSKL
DFPVHSIVTL
>Mature_170_residues
MKKLEDLILTYKDFPKKGIEFKDVLEILQYPDIFQDIILKMSSNQFLKKAEAIISIDARGFIFGSAVALESSKPMIVARK
PGKLPGQLLTREYDLEYGKNSLSIQVNALKKFNSFVIVDDLLATGGTVKSVSRLIRDQKKKILGLITVVELKSLKGKSKL
DFPVHSIVTL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=163, Percent_Identity=38.0368098159509, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=38.28125, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=35.9756097560976, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=35, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=36.1963190184049, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=33.9181286549708, Blast_Score=78, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=36.25, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROMS (A2BRV3)

Other databases:

- EMBL:   CP000551
- RefSeq:   YP_001009621.1
- ProteinModelPortal:   A2BRV3
- SMR:   A2BRV3
- STRING:   A2BRV3
- GeneID:   4717945
- GenomeReviews:   CP000551_GR
- KEGG:   pmb:A9601_12301
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A2BRV3
- ProtClustDB:   PRK02304
- BioCyc:   PMAR146891:A9601_12301-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19043; Mature: 19043

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLEDLILTYKDFPKKGIEFKDVLEILQYPDIFQDIILKMSSNQFLKKAEAIISIDARG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHEEECCCC
FIFGSAVALESSKPMIVARKPGKLPGQLLTREYDLEYGKNSLSIQVNALKKFNSFVIVDD
EEEECEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEEHHCCCEEEEHH
LLATGGTVKSVSRLIRDQKKKILGLITVVELKSLKGKSKLDFPVHSIVTL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MKKLEDLILTYKDFPKKGIEFKDVLEILQYPDIFQDIILKMSSNQFLKKAEAIISIDARG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHEEECCCC
FIFGSAVALESSKPMIVARKPGKLPGQLLTREYDLEYGKNSLSIQVNALKKFNSFVIVDD
EEEECEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEEHHCCCEEEEHH
LLATGGTVKSVSRLIRDQKKKILGLITVVELKSLKGKSKLDFPVHSIVTL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA