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The map label for this gene is ubiB [C]

Identifier: 123968722

GI number: 123968722

Start: 1003681

End: 1005210

Strand: Reverse

Name: ubiB [C]

Synonym: A9601_11891

Alternate gene names: 123968722

Gene position: 1005210-1003681 (Counterclockwise)

Preceding gene: 123968725

Following gene: 123968721

Centisome position: 60.2

GC content: 30.98

Gene sequence:

>1530_bases
ATGAAAAGATCTTATTCGGAATATTCAGCAAAAGAAGACTTTCTTTGGTTGATTTTGAGACCATGGATTTTTATCCCAAG
AGTTTTATATATCCTTTTAACTTTTATTTTTCTTTTTTTAAGAATACTTTTTCAAGGTAACAGTAAAAATAAAAATGTAC
AAAAAAATCTCTCGAAATATCTTTTTGATGTGATAACGGATTTAGGGCCTTGTTTTATCAAATTAGGCCAAGCACTCTCA
ACTAGACCAGATCTTGTTAGACAAGATTGGCTTACTGAACTTACAAACTTACAAGATAATCTCCCAGCATTTGATCACAA
AATTTCTTTAAAAATCATTGAAGAGGAACTTGGATCCCCTGCTAATGAATTATTTGAAGAGTTTCCAGATAGTCCTATTG
CTTCAGCAAGCTTAGGTCAAGTTTATAAAGCAAAATTAAATAATTCTTATCTAGCTGTGAAAGTACAGCGGCCAAATTTA
TACTTCCTTATAAGAAGAGATGTTGTAATCTTAAGGTTTTTAGGAACTTTTTTATCCCCACTCTTACCATTAAATATAGG
TGTTGGAATTGGAGAGATAATAGATGAATTCGGTAAGGCACTTTTTGATGAAATTGACTATCAAAAAGAGGCCGAAAATG
CTTTGAAGTTTGCAAATTTATTCAAAGAAAATCCAAATATTTTTATTCCTAAATTAGAAAAACAGTTTTCATCCAAAAGG
GTAATCACAACTTCTTGGATTGATGGAGTTAAGTTAAGAGATAGATTTTTACTAGAGGAAAATAACTTAATACCTGCTTC
GTTTATAAAAACATGTGTCATCAGTGGACTGCAGCAATTATTTGAATTTGGATATTTTCATGCAGACCCACATCCAGGAA
ATATGTTCGCTCTCAAAGGAGGAAATGCAGATAGTGGGAATTTAGCTTATGTTGATTTTGGAATGATGGATACTATTACA
AACTCAGATAGACTTACTCTTATTAAGGCAATAGTTCACATAATAAACGAAGAATATTATCTTCTCGCAGAAGATTTCCA
GAAATTAGGTTTTTTAACCAAAGAACAAGATCTTCAAAAACTTGTTGAACCATTAAAAGAAGTTCTAGGAGGATCTTTTG
GCGCTGAGGTTGGTAATTTTAATCTTAAAAATGTAACTGATAAATTCTCAAAACTAATGTATTCCTATCCTTTCAGGGTT
CCAAGTAGGTTTGCCTTAATAATTAGAGCAGTTGTTAGTCAAGAGGGTTTAGCACTAAGGTTGGATCCTGAATTTAAAAT
TCTAAAAATAGCTTATCCATATATTGCAAAAAAATTACTGACCGATAATTCTGAAGAGATTTTAGACATACTTTTAGAAG
TCGTTTTTGATAAAAAAGGTCAAATCCAAATAGAAAAAGTTGAAAGTTTACTAAACATTTTATTTAGAGATTCAGAGAAT
ATTAATTCAGATCTTATACCAGTTGCGAACGCTGGATTGAAATTATTTGTCAGTAAAAAGGATCCGAAGTTAGGAAGAAT
CTTCTTTTAG

Upstream 100 bases:

>100_bases
TAAAAACTTTTTAGTTAGAAAAGATGAAATGCTCATAAAGTATTATTGACATATATAGAATGGACTACATGGTAATCTTT
TTTGATATTTTTTAACTTTA

Downstream 100 bases:

>100_bases
TCTTATAAAAGATGAAAAATTAGAATTTACTGATGCAAAAAAACTCTTGGCTTTAATTAGAGATACTTTTAGTCCTCTAA
ATATTGCAAAAAGTGCAGTA

Product: kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKRSYSEYSAKEDFLWLILRPWIFIPRVLYILLTFIFLFLRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKISLKIIEEELGSPANELFEEFPDSPIASASLGQVYKAKLNNSYLAVKVQRPNL
YFLIRRDVVILRFLGTFLSPLLPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEKQFSSKR
VITTSWIDGVKLRDRFLLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADSGNLAYVDFGMMDTIT
NSDRLTLIKAIVHIINEEYYLLAEDFQKLGFLTKEQDLQKLVEPLKEVLGGSFGAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILDILLEVVFDKKGQIQIEKVESLLNILFRDSEN
INSDLIPVANAGLKLFVSKKDPKLGRIFF

Sequences:

>Translated_509_residues
MKRSYSEYSAKEDFLWLILRPWIFIPRVLYILLTFIFLFLRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKISLKIIEEELGSPANELFEEFPDSPIASASLGQVYKAKLNNSYLAVKVQRPNL
YFLIRRDVVILRFLGTFLSPLLPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEKQFSSKR
VITTSWIDGVKLRDRFLLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADSGNLAYVDFGMMDTIT
NSDRLTLIKAIVHIINEEYYLLAEDFQKLGFLTKEQDLQKLVEPLKEVLGGSFGAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILDILLEVVFDKKGQIQIEKVESLLNILFRDSEN
INSDLIPVANAGLKLFVSKKDPKLGRIFF
>Mature_509_residues
MKRSYSEYSAKEDFLWLILRPWIFIPRVLYILLTFIFLFLRILFQGNSKNKNVQKNLSKYLFDVITDLGPCFIKLGQALS
TRPDLVRQDWLTELTNLQDNLPAFDHKISLKIIEEELGSPANELFEEFPDSPIASASLGQVYKAKLNNSYLAVKVQRPNL
YFLIRRDVVILRFLGTFLSPLLPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEKQFSSKR
VITTSWIDGVKLRDRFLLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKGGNADSGNLAYVDFGMMDTIT
NSDRLTLIKAIVHIINEEYYLLAEDFQKLGFLTKEQDLQKLVEPLKEVLGGSFGAEVGNFNLKNVTDKFSKLMYSYPFRV
PSRFALIIRAVVSQEGLALRLDPEFKILKIAYPYIAKKLLTDNSEEILDILLEVVFDKKGQIQIEKVESLLNILFRDSEN
INSDLIPVANAGLKLFVSKKDPKLGRIFF

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=280, Percent_Identity=27.5, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI41393593, Length=268, Percent_Identity=28.7313432835821, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI217035081, Length=255, Percent_Identity=27.843137254902, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34147522, Length=246, Percent_Identity=29.6747967479675, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI27363457, Length=212, Percent_Identity=28.7735849056604, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI217416386, Length=212, Percent_Identity=28.7735849056604, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI2367309, Length=433, Percent_Identity=25.635103926097, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=276, Percent_Identity=30.4347826086957, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32565180, Length=210, Percent_Identity=31.4285714285714, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323282, Length=268, Percent_Identity=30.5970149253731, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325148, Length=445, Percent_Identity=22.0224719101124, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=246, Percent_Identity=28.0487804878049, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24662575, Length=386, Percent_Identity=24.8704663212435, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI22024280, Length=351, Percent_Identity=25.3561253561254, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859849, Length=352, Percent_Identity=25.5681818181818, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58231; Mature: 58231

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSYSEYSAKEDFLWLILRPWIFIPRVLYILLTFIFLFLRILFQGNSKNKNVQKNLSKY
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPAFDHKISLKIIEEELGSP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHHCCC
ANELFEEFPDSPIASASLGQVYKAKLNNSYLAVKVQRPNLYFLIRRDVVILRFLGTFLSP
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHH
LLPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEKQFSSKR
HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCC
VITTSWIDGVKLRDRFLLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKG
EEEECCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
GNADSGNLAYVDFGMMDTITNSDRLTLIKAIVHIINEEYYLLAEDFQKLGFLTKEQDLQK
CCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHH
LVEPLKEVLGGSFGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLALR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
LDPEFKILKIAYPYIAKKLLTDNSEEILDILLEVVFDKKGQIQIEKVESLLNILFRDSEN
ECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
INSDLIPVANAGLKLFVSKKDPKLGRIFF
CCCCCCEECCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKRSYSEYSAKEDFLWLILRPWIFIPRVLYILLTFIFLFLRILFQGNSKNKNVQKNLSKY
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LFDVITDLGPCFIKLGQALSTRPDLVRQDWLTELTNLQDNLPAFDHKISLKIIEEELGSP
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHHCCC
ANELFEEFPDSPIASASLGQVYKAKLNNSYLAVKVQRPNLYFLIRRDVVILRFLGTFLSP
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHH
LLPLNIGVGIGEIIDEFGKALFDEIDYQKEAENALKFANLFKENPNIFIPKLEKQFSSKR
HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCC
VITTSWIDGVKLRDRFLLEENNLIPASFIKTCVISGLQQLFEFGYFHADPHPGNMFALKG
EEEECCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
GNADSGNLAYVDFGMMDTITNSDRLTLIKAIVHIINEEYYLLAEDFQKLGFLTKEQDLQK
CCCCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHH
LVEPLKEVLGGSFGAEVGNFNLKNVTDKFSKLMYSYPFRVPSRFALIIRAVVSQEGLALR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEE
LDPEFKILKIAYPYIAKKLLTDNSEEILDILLEVVFDKKGQIQIEKVESLLNILFRDSEN
ECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCC
INSDLIPVANAGLKLFVSKKDPKLGRIFF
CCCCCCEECCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]