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The map label for this gene is hemC [H]

Identifier: 123968087

GI number: 123968087

Start: 479244

End: 480194

Strand: Reverse

Name: hemC [H]

Synonym: A9601_05521

Alternate gene names: 123968087

Gene position: 480194-479244 (Counterclockwise)

Preceding gene: 123968088

Following gene: 123968085

Centisome position: 28.76

GC content: 34.7

Gene sequence:

>951_bases
ATGACTAATTTTAAGCTAAAAATAGCTAGTAGAAGAAGTAAGCTAGCAATGGTTCAAACTTTATGGGTTAAAGATCAACT
AGAAAAAAATATTCCCAATTTAGAGGTATCTATAGAAGCCATGGCAACTCAAGGTGACAAAATCCTTGATGTAGCCTTAG
CAAAAATAGGCGACAAAGGCTTATTTACAAAAGAGCTTGAAGCACAAATGCTCGTAGGCCATGCAGATATAGCAGTACAT
TCTCTAAAAGATTTACCAACCAATTTGCCTAATGGACTTAAATTAGGATGCATTACAAAAAGGGAGGATCCTGCAGATGC
TTTAGTAGTAAACAAGAAAAATGACTGTTATAAATTAGAAAACTTACCTGAAGGTTCGATTGTTGGAACAAGCTCTCTAA
GAAGACTTGCACAATTAAGAAATAAGTACCCACATCTTGTTTTCAAAGATATCAGGGGAAATGTTATTACAAGAATTGAA
AAATTAGATGCAGGAGAATTTGATTGTATAATTCTTGCGGCCGCTGGTTTAAAGAGATTAGGCTTTGAATCAAGAATTCA
CCAGATTATCCCAAGTGAAGTTTCCCTTCATGCCGTTGGCCAAGGAGCACTAGGCATTGAATGTAAATCTGATGATAAAA
AAGTTTTAGAAATTATAAGTATCTTAGAAGATAAACCCACCTGTCAAAGATGTCTAGCAGAAAGGGCTTTTTTAAGAGAG
CTTGAAGGTGGATGCCAAGTCCCAATAGGTGTGAATAGTAAAATTCAAAATGAACAACTTTGCCTTACTGGTATGGTTGC
ATCTCTTGATGGAGAAAGGCTTATTAAAGATCAATATATTGGCGATATTAATGATCCCGAAGAAGTAGGCAAAGAACTAG
CTAAAAAATTAAAGCAGCAAGGTGCCGAAGAAATACTAAGCGAAATATTTAAAAAATTTAGAGAAAAATAA

Upstream 100 bases:

>100_bases
TAAAAAAAGTTAAGTATAATAATTAGCTTTAAAAACTGGCAAAATAATAGCTTAAAATAAATTCGACTTAATTTTTAATT
CAAACTCAAAATAATATTTA

Downstream 100 bases:

>100_bases
AATTAGTTAATTTACTAATTTAGGATCAATTTCTATTTTGTATCTCTCTTCACAATCTTTAATCACTTTAACAGCTTCTT
CTATCCCAAAAAAACCATTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVH
SLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLENLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEVSLHAVGQGALGIECKSDDKKVLEIISILEDKPTCQRCLAERAFLRE
LEGGCQVPIGVNSKIQNEQLCLTGMVASLDGERLIKDQYIGDINDPEEVGKELAKKLKQQGAEEILSEIFKKFREK

Sequences:

>Translated_316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVH
SLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLENLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEVSLHAVGQGALGIECKSDDKKVLEIISILEDKPTCQRCLAERAFLRE
LEGGCQVPIGVNSKIQNEQLCLTGMVASLDGERLIKDQYIGDINDPEEVGKELAKKLKQQGAEEILSEIFKKFREK
>Mature_315_residues
TNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVHS
LKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLENLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIEK
LDAGEFDCIILAAAGLKRLGFESRIHQIIPSEVSLHAVGQGALGIECKSDDKKVLEIISILEDKPTCQRCLAERAFLREL
EGGCQVPIGVNSKIQNEQLCLTGMVASLDGERLIKDQYIGDINDPEEVGKELAKKLKQQGAEEILSEIFKKFREK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=51.4084507042254, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=51.4084507042254, Blast_Score=288, Evalue=5e-78,
Organism=Escherichia coli, GI48994974, Length=311, Percent_Identity=50.1607717041801, Blast_Score=296, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=44.9367088607595, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI20130425, Length=315, Percent_Identity=44.1269841269841, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35034; Mature: 34903

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEECC
NLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
CCCCCCEECHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHH
GFESRIHQIIPSEVSLHAVGQGALGIECKSDDKKVLEIISILEDKPTCQRCLAERAFLRE
CHHHHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEGGCQVPIGVNSKIQNEQLCLTGMVASLDGERLIKDQYIGDINDPEEVGKELAKKLKQQ
HCCCCEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAEEILSEIFKKFREK
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEECC
NLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
CCCCCCEECHHHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHH
GFESRIHQIIPSEVSLHAVGQGALGIECKSDDKKVLEIISILEDKPTCQRCLAERAFLRE
CHHHHHHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEGGCQVPIGVNSKIQNEQLCLTGMVASLDGERLIKDQYIGDINDPEEVGKELAKKLKQQ
HCCCCEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAEEILSEIFKKFREK
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA