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The map label for this gene is cyoB [H]

Identifier: 123968037

GI number: 123968037

Start: 434649

End: 436274

Strand: Reverse

Name: cyoB [H]

Synonym: A9601_05001

Alternate gene names: 123968037

Gene position: 436274-434649 (Counterclockwise)

Preceding gene: 123968038

Following gene: 123968036

Centisome position: 26.13

GC content: 36.22

Gene sequence:

>1626_bases
ATGACAATATCAATTGATCCACAAAAAACTAATAATGAAAGCCTTCAACCTAAAGGCTGGCTTAGATACTTTAGTTTTAG
CCTTGATCATAAAGTAATTGGGATACAATACTTGGTTTGTGGTTTTCTCTTCTACTTAATAGGAGGAACCTTAGCGAGCG
CTATAAGAATTGAACTAGCTAGTCCAATGTCTGATTTCATGCCAAGAGATGTTTATAACCAAGTTTTAACTTTACACGGA
ACAATAATGATATTCCTGTGGATAGTTCCTGTAGTCAACGGGGCTTTTGGAAATTATTTGATTCCATTTTATGTAGGTGC
GAGAGATATGGCATTCCCAAGATTAAATGCAGTAGCTTTTTGGTTAATTCCTCCTTCAGGTTTGATGCTGGTAGCAAGCT
ATTTTGTTGAGGGTGCTGCTCAGGCTGGATGGACGGCTTATCCTCCTTTGAGCATAACTACGCCTCAATCGGGACAAATT
ATTTGGATTCTTAGCGTTCTATTACTTGGAGGCAGCTCTATATTTGGTGGAATAAACTTTATAGCGACCATTATCAAATT
AAGAAGACCAGGATTAAAACTTATGCAATTGCCAATGTATTGTTGGGCAATGCTTGGAACAAGTCTATTAGTTGTTTTGT
CAACTCCTGTTTTAGCAGGCACTTTAATTCTACTTAGCTTCGATATCATTGCTAATACAGGTTTTTTCAATCCTGTTTTA
GGTGGCAATGTCGTAGTTTATCAGCATTTATTTTGGTTTTATTCTCATCCAGCTGTGTACATAATGGTCCTTCCTGCCTT
TGGATTAGTTAGTGAAATACTTCCTGTACATGCTAGAAAACCACTTTTTGGATATACAACAATGGTTTTTTCAATAATGG
GGATAGTAGTTTTAGGTTTAGTTGTTTGGGCGCATCACATGTTTACCAGTGGAACGCCCCCTTGGATGAGATTATTCTTT
ACTATCGCAACAGCATTTATTGCTGTTCCAACAGGTATAAAATTTTTCAACTGGGTTGCAACATTATGGGGAGGTAAAAT
TTCCATCAATAGTGCAATACTATTCTCTTGCGGATTTATTATAAATTTTGTTTTTGGAGGTATTACAGGAGTTGCTTTGG
CACAGGTACCTTTCGATATTCACGTACATGATACCTATTTCGTTGTAGCCCATTTTCATTACATAGTTTATGGAGGGACT
GTTTTTATTATTTTCTCTTCAATTTATCATTGGTTCCCCAAAGTAACTGGAAAAATGCTCAATGAAAAATTAGGAATTTT
ACATTTTATCATTACCTTTATTGGATTTAACTTGTGCTTTGCTCCTCAACATTGGCTTGGTTTAAATGGAATGCCAAGAA
GAGTTGCAGAATATGATCCTCAATTCCAGTTTGTAAATCAAATTAGTAGCCTTGGGGCTCTTTTGATGGCTATAAGTACA
ATTCCTTTTTTAATAAATGTAATCATTAGCGTGAGGAATGGGAAAGATGCTGGAGATAACCCTTGGAACGCTCTTACACC
TGAATGGTTAACATCTTCTCCACCTCCAGTGGAAAATTGGGAAGGAGAAGCTCCATTAGTTGAAGAACCTTATGGTTATG
GTAAAGAAATTTATGAACAAAAATAA

Upstream 100 bases:

>100_bases
GTGGCCCATATCATGGAGGGATGAGAGCCTCAATAATTGTTGAAGAAGAATCTGATTACAACGAATGGTTTAACAAAAAT
AAAAAACCAGAGGTAAATTT

Downstream 100 bases:

>100_bases
ATGACAACTCTAGATAGCTCAAAAGAAATTCAAAAAAATAATTCTGAAGTTAATGAAACACATGAAGACTTCAGAATGTT
TGGTCTTGTAACTTTCCTAA

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGTLASAIRIELASPMSDFMPRDVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQI
IWILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISINSAILFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGT
VFIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
IPFLINVIISVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEIYEQK

Sequences:

>Translated_541_residues
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGTLASAIRIELASPMSDFMPRDVYNQVLTLHG
TIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQI
IWILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFF
TIATAFIAVPTGIKFFNWVATLWGGKISINSAILFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGT
VFIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
IPFLINVIISVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEIYEQK
>Mature_540_residues
TISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGTLASAIRIELASPMSDFMPRDVYNQVLTLHGT
IMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAFWLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQII
WILSVLLLGGSSIFGGINFIATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVLG
GNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGLVVWAHHMFTSGTPPWMRLFFT
IATAFIAVPTGIKFFNWVATLWGGKISINSAILFSCGFIINFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTV
FIIFSSIYHWFPKVTGKMLNEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAISTI
PFLINVIISVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEIYEQK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=501, Percent_Identity=44.5109780439122, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1786634, Length=511, Percent_Identity=40.9001956947162, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226519, Length=525, Percent_Identity=38.4761904761905, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6226524, Length=318, Percent_Identity=39.937106918239, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=36.5853658536585, Blast_Score=149, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60172; Mature: 60041

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGTLASAIRIELA
CEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPMSDFMPRDVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQIIWILSVLLLGGSSIFGGINF
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHH
IATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGL
CCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISINSAILFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTVFIIFSSIYHWFPKVTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
HHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IPFLINVIISVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEIYEQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
K
C
>Mature Secondary Structure 
TISIDPQKTNNESLQPKGWLRYFSFSLDHKVIGIQYLVCGFLFYLIGGTLASAIRIELA
EEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPMSDFMPRDVYNQVLTLHGTIMIFLWIVPVVNGAFGNYLIPFYVGARDMAFPRLNAVAF
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEE
WLIPPSGLMLVASYFVEGAAQAGWTAYPPLSITTPQSGQIIWILSVLLLGGSSIFGGINF
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCHHHHHHHH
IATIIKLRRPGLKLMQLPMYCWAMLGTSLLVVLSTPVLAGTLILLSFDIIANTGFFNPVL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GGNVVVYQHLFWFYSHPAVYIMVLPAFGLVSEILPVHARKPLFGYTTMVFSIMGIVVLGL
CCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VVWAHHMFTSGTPPWMRLFFTIATAFIAVPTGIKFFNWVATLWGGKISINSAILFSCGFI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECHHHHHHHHHH
INFVFGGITGVALAQVPFDIHVHDTYFVVAHFHYIVYGGTVFIIFSSIYHWFPKVTGKML
HHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NEKLGILHFIITFIGFNLCFAPQHWLGLNGMPRRVAEYDPQFQFVNQISSLGALLMAIST
HHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
IPFLINVIISVRNGKDAGDNPWNALTPEWLTSSPPPVENWEGEAPLVEEPYGYGKEIYEQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]