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The map label for this gene is folK [C]

Identifier: 123965555

GI number: 123965555

Start: 295902

End: 296480

Strand: Reverse

Name: folK [C]

Synonym: P9515_03201

Alternate gene names: 123965555

Gene position: 296480-295902 (Counterclockwise)

Preceding gene: 123965557

Following gene: 123965554

Centisome position: 17.4

GC content: 27.46

Gene sequence:

>579_bases
ATGTTTTTTTTAGTGGAATTATCAAATCTTAATATCAAAAATGGACTATGTATATCATTAGGAGCAAATATTGATAGTAA
TTATGGAAAACCTATTGAAACATTTATAATTTGCAAACCAAAAATTGAGACTTTAATAAAGAGTTGGATAAACCAATCTA
AATATTGTAATAAAGAAACTGAATCATCTGAAACAATTTTTTATTGGTCTTCAATATATGAATCAAGTCCTCATGGAGTC
AAGGATAATCAACCAAATTATCTAAACACACTTGTCCTAGTCAAAAGTAACTCTTTCCCAAAGCAAACAACAGAAAATGC
AAAATTCCTTCTAAGAGAATTTAAAAATTTGGAAAGAAATTTTGGAAGAAAAAAGACTCCCAATAACATGAAATGGTTAT
CTAGATGTTTAGATTTAGATATTTTATGGTGGGAAGATTTTTGTTTCAAGGATGAAGAATTAATATTACCTCACCCAAGA
TTTATGAATCGTAATTTTATAATATCTCCCCTTTCTGAAGTCTTAAGTAGAACACAAACAGTTAAAAAAGTTGAAGAAGA
AAGATGGCTTGTTGATTAA

Upstream 100 bases:

>100_bases
AATCTTTCTTTTTCATTAAATCCTTTATGTCTTCTTTTCCTTTTAACTTTTTTTCCAAAATCACTTTAAAAATCCCTGAT
ATAGAATTTATCCAATAACA

Downstream 100 bases:

>100_bases
TTTCCAAAATCCTAAAATAACTGTTAGGGTATTTTTATTTAAATTATGGATGATAACATTCACTTCAAAAAAGCCATTTT
TAAAGAAAAAATCTCCGAGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: AMP; 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

Alternate protein names: Dihydroneopterin Aldolase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MFFLVELSNLNIKNGLCISLGANIDSNYGKPIETFIICKPKIETLIKSWINQSKYCNKETESSETIFYWSSIYESSPHGV
KDNQPNYLNTLVLVKSNSFPKQTTENAKFLLREFKNLERNFGRKKTPNNMKWLSRCLDLDILWWEDFCFKDEELILPHPR
FMNRNFIISPLSEVLSRTQTVKKVEEERWLVD

Sequences:

>Translated_192_residues
MFFLVELSNLNIKNGLCISLGANIDSNYGKPIETFIICKPKIETLIKSWINQSKYCNKETESSETIFYWSSIYESSPHGV
KDNQPNYLNTLVLVKSNSFPKQTTENAKFLLREFKNLERNFGRKKTPNNMKWLSRCLDLDILWWEDFCFKDEELILPHPR
FMNRNFIISPLSEVLSRTQTVKKVEEERWLVD
>Mature_192_residues
MFFLVELSNLNIKNGLCISLGANIDSNYGKPIETFIICKPKIETLIKSWINQSKYCNKETESSETIFYWSSIYESSPHGV
KDNQPNYLNTLVLVKSNSFPKQTTENAKFLLREFKNLERNFGRKKTPNNMKWLSRCLDLDILWWEDFCFKDEELILPHPR
FMNRNFIISPLSEVLSRTQTVKKVEEERWLVD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.6.3

Molecular weight: Translated: 22684; Mature: 22684

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFLVELSNLNIKNGLCISLGANIDSNYGKPIETFIICKPKIETLIKSWINQSKYCNKET
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCC
ESSETIFYWSSIYESSPHGVKDNQPNYLNTLVLVKSNSFPKQTTENAKFLLREFKNLERN
CCCCEEEEEEHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRKKTPNNMKWLSRCLDLDILWWEDFCFKDEELILPHPRFMNRNFIISPLSEVLSRTQT
CCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCCCCCEEECCHHHHHHHHHH
VKKVEEERWLVD
HHHHHHHHCCCC
>Mature Secondary Structure
MFFLVELSNLNIKNGLCISLGANIDSNYGKPIETFIICKPKIETLIKSWINQSKYCNKET
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCC
ESSETIFYWSSIYESSPHGVKDNQPNYLNTLVLVKSNSFPKQTTENAKFLLREFKNLERN
CCCCEEEEEEHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRKKTPNNMKWLSRCLDLDILWWEDFCFKDEELILPHPRFMNRNFIISPLSEVLSRTQT
CCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCCCCCEEECCHHHHHHHHHH
VKKVEEERWLVD
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {ATP}} 0.017 {ATP}} [C]

Substrates: ATP; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine

Specific reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

General reaction: Diphsphate transfer [C]

Inhibitor: 2-Amino-4-hydroxy -6-carboxydihydropteridine [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA