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The map label for this gene is dprE1

Identifier: 121639707

GI number: 121639707

Start: 4208182

End: 4209567

Strand: Direct

Name: dprE1

Synonym: BCG_3852

Alternate gene names: 121639707

Gene position: 4208182-4209567 (Clockwise)

Preceding gene: 121639706

Following gene: 121639708

Centisome position: 96.2

GC content: 64.0

Gene sequence:

>1386_bases
ATGTTGAGCGTGGGAGCTACCACTACCGCCACCCGGCTGACCGGGTGGGGCCGCACAGCGCCGTCGGTGGCGAATGTGCT
TCGCACCCCAGATGCCGAGATGATCGTCAAGGCGGTGGCTCGGGTCGCCGAGTCGGGGGGCGGCCGGGGTGCTATCGCGC
GCGGGCTGGGCCGCTCCTATGGGGACAACGCCCAAAACGGCGGTGGGTTGGTGATCGACATGACGCCGCTGAACACTATC
CACTCCATTGACGCCGACACCAAGCTGGTCGACATCGACGCCGGGGTCAACCTCGACCAACTGATGAAAGCCGCCCTGCC
GTTCGGGCTGTGGGTCCCGGTGCTGCCGGGAACCCGGCAGGTCACCGTCGGTGGGGCGATCGCCTGCGATATCCACGGCA
AGAACCATCACAGCGCTGGCAGCTTCGGTAACCACGTGCGCAGCATGGACCTGCTGACCGCCGACGGCGAGATCCGTCAT
CTCACTCCGACCGGCGAGGACGCCGAACTGTTCTGGGCCACCGTCGGGGGCAACGGTCTCACCGGCATCATCATGCGGGC
CACCATCGAGATGACGCCCACTTCGACGGCGTACTTCATCGCCGACGGCGACGTCACCGCCAGCCTCGACGAGACCATCG
CCCTGCACAGCGACGGCAGCGAAGCGCGCTACACCTATTCCAGTGCCTGGTTCGACGCGATCAGCGCTCCCCCGAAGCTG
GGCCGCGCGGCGGTATCGCGTGGCCGCCTGGCCACCGTCGAGCAATTGCCTGCGAAACTGCGGAGCGAACCTTTGAAATT
CGATGCGCCACAGCTACTTACGTTGCCCGACGTGTTTCCCAACGGGCTGGCCAACAAATATACCTTCGGCCCGATCGGCG
AACTGTGGTACCGCAAATCCGGCACCTATCGCGGCAAGGTCCAGAACCTCACGCAGTTCTACCATCCGCTGGACATGTTC
GGCGAATGGAACCGCGCCTACGGCCCAGCGGGCTTCCTGCAATATCAGTTCGTGATCCCCACAGAGGCGGTTGATGAGTT
CAAGAAGATCATCGGCGTTATTCAAGCCTCGGGTCACTACTCGTTTCTCAACGTGTTCAAGCTGTTCGGCCCCCGCAACC
AGGCGCCGCTCAGCTTCCCCATCCCGGGCTGGAACATCTGCGTCGACTTCCCCATCAAGGACGGGCTGGGGAAGTTCGTC
AGCGAACTCGACCGCCGGGTACTGGAATTCGGCGGCCGGCTCTACACCGCCAAAGACTCCCGTACCACCGCCGAAACCTT
TCATGCCATGTATCCGCGCGTCGACGAATGGATCTCCGTGCGCCGCAAGGTCGATCCGCTGCGCGTATTCGCCTCCGACA
TGGCCCGACGCTTGGAGCTGCTGTAG

Upstream 100 bases:

>100_bases
GGGCACCGCCACGGTAATCAACTTCATCGTGCAGCGAGCCGTGATCTTCCGGATCCGCTGAGCCGGTCAGGGTCGAATCG
GGCGGGTACCCTCTTTGACG

Downstream 100 bases:

>100_bases
ATGGTTCTTGATGCCGTAGGAAACCCCCAGACGGTGCTGCTGCTCGGTGGCACCTCCGAGATCGGGCTCGCCATCTGCGA
GCGCTACCTGCACAATTCGG

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTI
HSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRH
LTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMF
GEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFV
SELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL

Sequences:

>Translated_461_residues
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTI
HSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRH
LTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMF
GEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFV
SELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
>Mature_461_residues
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTI
HSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRH
LTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMF
GEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFV
SELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPRE1_MYCTU (P72056)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   B70697
- RefSeq:   NP_218307.1
- RefSeq:   NP_338449.1
- ProteinModelPortal:   P72056
- EnsemblBacteria:   EBMYCT00000003924
- EnsemblBacteria:   EBMYCT00000070339
- GeneID:   886125
- GeneID:   926348
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3898
- KEGG:   mtu:Rv3790
- TIGR:   MT3898
- TubercuList:   Rv3790
- GeneTree:   EBGT00050000015453
- HOGENOM:   HBG334843
- OMA:   TLALDFP
- ProtClustDB:   CLSK872248
- BioCyc:   MetaCyc:MONOMER-15261
- GO:   GO:0040007
- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.20

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4; SSF56176 FAD-binding_2

EC number: NA

Molecular weight: Translated: 50164; Mature: 50164

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS51387 FAD_PCMH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
CCCCCCCCHHHEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
CCCCCCCCEEEEEECCCCHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCEE
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
EEECCEEEEEECCCCCCCCCCHHHHHHEEEEEECCCCEEEECCCCCCCEEEEEEECCCCC
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
EEEEEEEEEEECCCCEEEEEECCCEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCCHHH
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHCC
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
CCCCCHHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCH
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
HHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
CHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
CCCCCCCCHHHEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
CCCCCCCCEEEEEECCCCHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCCCEE
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
EEECCEEEEEECCCCCCCCCCHHHHHHEEEEEECCCCEEEECCCCCCCEEEEEEECCCCC
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
EEEEEEEEEEECCCCEEEEEECCCEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCCHHH
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHCC
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
CCCCCHHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCH
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
HHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
CHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036