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The map label for this gene is bdhA [H]

Identifier: 121639642

GI number: 121639642

Start: 4144989

End: 4146182

Strand: Direct

Name: bdhA [H]

Synonym: BCG_3786

Alternate gene names: 121639642

Gene position: 4144989-4146182 (Clockwise)

Preceding gene: 121639641

Following gene: 121639643

Centisome position: 94.75

GC content: 65.33

Gene sequence:

>1194_bases
ATGAAGGCGGTGACCTGCACCAACGCAAAGCTCGAGGTAGTCGACCGGCCGTCCCCGGCGCCGGCCAAGGGTCAACTGTT
GCTCGATGTGCTGCGGTGCGGTATCTGCGGATCGGACCTGCATGCCCGCTTGCACTGTGATGAACTGGCCGACGTGATGG
CCGAATCTGGCTACCACGCCTTCATGCGATCGAATCAGCAGGTGGTGTTCGGACACGAGTTCTGTGGCGAGGTGGTCGAT
TACGGTCCCGGCACCCGCAGGACCCCTAGGCGCGGCACCCCGGTCGTCGCCATGCCGCTGCTGCGGCGTGGCAACAAAGA
GGTGCACGGGATCGGGCTTTCGACAATGGCGCCGGGCGCCTACGCCGAGCGGCTCGTCGTCGAGCAGTCGCTGACGTTTC
CTGTCCCGAACGGGCTGGCGCCCGAGATAGCCGCGCTGACCGAGCCCATGGCCGTCGGATGGCACGCCGTCCGGCGCGGC
GAGGTGGGCAAGGGCGACGTCGCGATCGTGATCGGGTGCGGTCCGATCGGCCTCGCGGTGATCTGCATGCTGAAGTCGCG
CGGGGTACACACGGTGATCGCAAGCGACTTTTCACCCGGCCGTCGTGCCCTCGCAACCGCCTGTGGCGCTGATTCCGTAG
TCGATCCCGTACAGGACTCACCGTATGCGGTAGCCGCCGGCCTTGGACAGGGAAACAGACACCTGCAAAGCATCCTCGAC
GCGTTCGACCTCGCAGTCGGCACGGTCGAAAGCCTGCAGCGGCTGCGGCTGCCGTGGTGGCACCTTTGGCGGGCTGCCGA
AGCAGCTGGCGCCGCAACGCCAAAGCGTCCAGTCATCTTCGAATGTGTTGGCGTTCCGGGAATTATCGATGGCATCATCG
CCAGCGCACCGCTGTTCTCGCGCGTCGTCGTGGTCGGCGTCTGCATGGGCTCAGACCACATCCGGCCGGCGATGGCGATC
AACAAAGAGATCAACCTGCGGTTCGTCCTCGGCTACACACCGTTAGAGTTCCGCGACACGTTGCACATGCTGGCCGACGG
CAAGGTCAACGCCGCGCCGCTGATCACCGGGACGGTCGGTTTACCCGGCGTGGCGGCAGCATTCGATGCGCTCGGCGATC
CCGAGGCGCACGCAAAAATCATGATCGACCCCAAGAGCAACGCCGCGAGTCCCCAACCATTCCGCGTGGAGTGA

Upstream 100 bases:

>100_bases
CCAGCGTCACCACAATAGCGGTGGCCACGTAGTCCATGGTGACAGCCCCGCCACGGCGCACGTTCAGGCCGCTTGCTGTC
GGATCGAGAGGACCTACGCG

Downstream 100 bases:

>100_bases
ATGATGCGGGATAGCCGCACGGCGTTGGATCCACCCGGGACGACAGCTTGAATTCAGGCGGCCTCTGCTTTAAAGCGCAC
ACTACCGCGCCTGCTGCGGC

Product: putative dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVD
YGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRG
EVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILD
AFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAI
NKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE

Sequences:

>Translated_397_residues
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVD
YGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRG
EVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILD
AFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAI
NKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE
>Mature_397_residues
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVD
YGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRG
EVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILD
AFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAI
NKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=372, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=216, Percent_Identity=31.9444444444444, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787863, Length=220, Percent_Identity=28.6363636363636, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082125, Length=219, Percent_Identity=27.3972602739726, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788073, Length=234, Percent_Identity=27.3504273504274, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790045, Length=240, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=374, Percent_Identity=25.4010695187166, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=216, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=405, Percent_Identity=26.4197530864197, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=258, Percent_Identity=29.4573643410853, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17737897, Length=371, Percent_Identity=23.989218328841, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137530, Length=369, Percent_Identity=22.4932249322493, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 41967; Mature: 41967

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHA
CCCEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHEECHHHHHHHHHHCCCHH
FMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGA
HHCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEECCHHCCCCH
YAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRGEVGKGDVAIVIGCGPIGLAV
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHH
ICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILD
HHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
AFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCHHHH
RVVVVGVCMGSDHIRPAMAINKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVG
HHHHEEEEECCCCCCCHHEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCC
LPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE
CCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHA
CCCEEECCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHEECHHHHHHHHHHCCCHH
FMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGA
HHCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEECCHHCCCCH
YAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRGEVGKGDVAIVIGCGPIGLAV
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHH
ICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILD
HHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
AFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHCCHHHH
RVVVVGVCMGSDHIRPAMAINKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVG
HHHHEEEEECCCCCCCHHEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCC
LPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE
CCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]