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The map label for this gene is cysM [C]

Identifier: 121639598

GI number: 121639598

Start: 4098552

End: 4099592

Strand: Direct

Name: cysM [C]

Synonym: BCG_3743

Alternate gene names: 121639598

Gene position: 4098552-4099592 (Clockwise)

Preceding gene: 121639597

Following gene: 121639603

Centisome position: 93.69

GC content: 65.61

Gene sequence:

>1041_bases
TTGATCGAGGCGGACGCCCGCCGTAGCGCCGACACCCACCTGCTGCGCTACCCACTGCCCGCTGCCTGGTGCACGGATGT
CGACGTCGAGCTGTACCTCAAGGACGAGACGACCCATATCACCGGCAGTCTCAAACACCGGTTGGCACGTTCGTTGTTCC
TCTATGCGCTATGCAACGGCTGGATCAACGAGAACACCACGGTGGTGGAGGCATCGTCGGGTTCAACGGCGGTGTCCGAG
GCCTATTTCGCGGCGCTGCTGGGTCTGCCGTTCATCGCCGTGATGCCGGCCGCGACCAGCGCTTCCAAAATCGCGTTGAT
CGAATCACAAGGTGGCCGTTGTCATTTCGTCCAGAATTCAAGTCAAGTGTACGCCGAGGCGGAGCGCGTCGCCAAGGAAA
CCGGCGGCCACTATCTGGACCAGTTCACCAACGCGGAGCGCGCAACCGACTGGCGCGGCAACAACAACATCGCCGAGTCG
ATCTACGTGCAAATGCGCGAAGAGAAGCACCCCACCCCGGAATGGATCGTCGTGGGTGCGGGCACCGGCGGAACCAGCGC
GACGATCGGCCGCTACATCCGCTACCGACGGCACGCGACCCGGCTGTGCGTCGTCGATCCGGAGAATTCCGCGTTCTTCC
CCGCGTACTCCGAAGGCCGGTACGACATCGTCATGCCCACATCGTCCCGTATCGAGGGCATCGGCCGGCCGCGGGTCGAG
CCGTCGTTTCTGCCCGGTGTGGTCGACCGCATGGTGGCGGTCCCCGACGCGGCGTCGATCGCTGCCGCCCGGCATGTCAG
CGCCGTTCTGGGGCGCCGAGTGGGACCGTCTACCGGCACCAACCTCTGGGGCGCGTTCGGACTGCTCGCCGAGATGGTCA
AGCAGGGCCGCAGCGGCTCGGTGGTCACACTGCTCGCCGACAGCGGCGATCGCTACGCCGACACCTACTTTTCCGACGAG
TGGGTCAGTGCCCAGGGGCTCGATCCGGCCGGGCCGGCTGCGGCGCTGGTGGAATTCGAGCGCTCCTGTCGATGGACGTG
A

Upstream 100 bases:

>100_bases
ACCTGGGCCGCTCACAGCCGACAGTGTCGGTGCGTTGAGCGGCGGGGCCTGTATCGCGGTCCGCAGCCTATCCCGGAGCT
GGACGGACAACGCGATCCGG

Downstream 100 bases:

>100_bases
CGGTCGGACCTGCGGTTTGGCTAGTCAACGGTCCGGTGCGATAGGCTGTCGTGGCTTCAAGCGGGGTGTGGCGCAGCTTG
GTAGCGCGCTTCGTTCGGGA

Product: putative lyase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWINENTTVVEASSGSTAVSE
AYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAES
IYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE
PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADSGDRYADTYFSDE
WVSAQGLDPAGPAAALVEFERSCRWT

Sequences:

>Translated_346_residues
MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWINENTTVVEASSGSTAVSE
AYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAES
IYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE
PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADSGDRYADTYFSDE
WVSAQGLDPAGPAAALVEFERSCRWT
>Mature_346_residues
MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWINENTTVVEASSGSTAVSE
AYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAES
IYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE
PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADSGDRYADTYFSDE
WVSAQGLDPAGPAAALVEFERSCRWT

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=27.3885350318471, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=27.3885350318471, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=27.3885350318471, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI2367138, Length=307, Percent_Identity=25.4071661237785, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=323, Percent_Identity=34.3653250773994, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539800, Length=330, Percent_Identity=31.2121212121212, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539640, Length=360, Percent_Identity=27.5, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=26.0450160771704, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=26.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=324, Percent_Identity=25, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=27.6073619631902, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37642; Mature: 37642

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNG
CCCCCCCCCCCCEEEECCCCCHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCC
WINENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNS
CCCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCEEEEEECCCCEEEEEECC
SQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAESIYVQMREEKHPTPEWIVVGA
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCEEEEECCHHHHCCCCCCCCC
PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGS
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
VVTLLADSGDRYADTYFSDEWVSAQGLDPAGPAAALVEFERSCRWT
EEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNG
CCCCCCCCCCCCEEEECCCCCHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHCC
WINENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNS
CCCCCCEEEEECCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCEEEEEECCCCEEEEEECC
SQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAESIYVQMREEKHPTPEWIVVGA
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVE
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCEECCCCCCCCEEEEECCHHHHCCCCCCCCC
PSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGS
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
VVTLLADSGDRYADTYFSDEWVSAQGLDPAGPAAALVEFERSCRWT
EEEEEECCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]