Click here to switch to the map view.

The map label for this gene is hmp

Identifier: 121639491

GI number: 121639491

Start: 3991309

End: 3992385

Strand: Direct

Name: hmp

Synonym: BCG_3636

Alternate gene names: 121639491

Gene position: 3991309-3992385 (Clockwise)

Preceding gene: 121639484

Following gene: 121639492

Centisome position: 91.24

GC content: 66.85

Gene sequence:

>1077_bases
TTGACCGAGGCAATTGGAGACGAGCCACTCGGCGACCACGTCCTTGAACTGCAGATCGCCGAGGTCGTCGACGAAACCGA
CGAGGCGCGATCGCTGGTCTTCGCGGTGCCCGACGGATCGGACGACCCGGAGATCCCCCCTCGGCGCCTGCGTTACGCCC
CCGGCCAATTCTTGACGCTGCGCGTGCCCAGCGAGCGTACCGGTTCGGTGGCGCGCTGCTACTCGTTGTGCAGTTCGCCC
TACACCGACGACGCCTTGGCGGTCACGGTCAAACGAACCGCCGACGGGTACGCCTCCAACTGGTTGTGCGATCACGCGCA
GGTGGGCATGCGCATCCACGTGCTGGCCCCGTCGGGCAACTTCGTCCCCACAACCCTCGACGCCGATTTCCTCCTGCTGG
CAGCGGGTAGCGGCATCACCCCGATCATGTCGATCTGCAAATCGGCGCTTGCCGAGGGCGGTGGACAGGTGACGCTGCTC
TACGCCAACCGCGACGACCGCTCGGTCATCTTCGGAGACGCGCTGCGCGAGTTGGCGGCGAAGTATCCCGACCGGCTCAC
GGTGCTGCACTGGCTAGAGTCGCTGCAGGGGCTGCCGAGCGCGAGCGCGCTGGCCAAGCTCGTCGCGCCCTACACCGACC
GGCCGGTGTTCATCTGTGGGCCCGGCCCGTTCATGCAGGCGGCCCGGGACGCCCTGGCGGCGCTGAAAGTGCCCGCCCAA
CAGGTGCACATCGAGGTGTTCAAGTCGCTGGAATCGGATCCGTTCGCGGCCGTCAAGGTCGACGACAGCGGTGACGAGGC
GCCGGCGACCGCGGTGGTGGAACTCGACGGCCAAACCCACACCGTCTCCTGGCCGCGCACCGCCAAGCTGCTCGACGTGC
TGCTGGCCGCGGGCCTGGACGCGCCGTTCTCCTGCCGGGAAGGCCACTGCGGTGCGTGTGCGTGCACCCTGCGCGCCGGC
AAAGTGAATATGGGAGTCAACGACGTGCTCGAGCAGCAGGATCTCGATGAGGGACTGATTTTGGCCTGTCAATCTCGCCC
GGAATCTGATTCGGTGGAAGTGACCTACGACGAGTAG

Upstream 100 bases:

>100_bases
CGTTCCGATTTGTGTCGAGCTAGGTATTCCTGCGGCAGGTAGCGATACCAAATGGGTTTTCTGTAACATGTTCTAGTTAT
GACGGAAGAGAGGACGGGTC

Downstream 100 bases:

>100_bases
TCCCGGAAGGGAGCGAGATGACGCGGCTGATACCGGGTTGCACGCTCGTCGGGCTGATGCTGACGTTACTGCCCGCGCCC
ACCTCGGCGGCCGGGAGCAA

Product: putative hemoglobine-related protein hmp

Products: NA

Alternate protein names: Rieske-type oxygenase; RO

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSP
YTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLL
YANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQ
QVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAG
KVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE

Sequences:

>Translated_358_residues
MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSP
YTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLL
YANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQ
QVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAG
KVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE
>Mature_357_residues
TEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPY
TDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLY
ANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQQ
VHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAGK
VNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

Organism=Escherichia coli, GI1787658, Length=357, Percent_Identity=33.6134453781513, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787098, Length=308, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788903, Length=211, Percent_Identity=30.8056872037915, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788104, Length=338, Percent_Identity=25.4437869822485, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24655635, Length=173, Percent_Identity=32.9479768786127, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KSHB_MYCTU (P96853)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842583
- PIR:   A70606
- RefSeq:   NP_218088.1
- RefSeq:   NP_338221.1
- HSSP:   P00256
- ProteinModelPortal:   P96853
- EnsemblBacteria:   EBMYCT00000001344
- EnsemblBacteria:   EBMYCT00000069858
- GeneID:   887315
- GeneID:   926538
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3676
- KEGG:   mtu:Rv3571
- TIGR:   MT3676
- TubercuList:   Rv3571
- GeneTree:   EBGT00050000015208
- HOGENOM:   HBG483999
- OMA:   MEVNDVL
- ProtClustDB:   CLSK872207
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR00371
- PRINTS:   PR00410

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1; SSF54292 Ferredoxin; SSF63380 Riboflavin_synthase_like_b-brl

EC number: 1.-.-.- [C]

Molecular weight: Translated: 38266; Mature: 38134

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCEEEE
RVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGN
ECCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEECCCCCCEEEEEECCCCC
FVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAA
EEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHH
KYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQ
HCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHH
QVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLD
HHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHCCC
APFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE
CCCCCCCCCCCEEEEEEECCEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECC
>Mature Secondary Structure 
TEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPEIPPRRLRYAPGQFLTL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCEEEE
RVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWLCDHAQVGMRIHVLAPSGN
ECCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEECCCCCCEEEEEECCCCC
FVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLLYANRDDRSVIFGDALRELAA
EEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHH
KYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFICGPGPFMQAARDALAALKVPAQ
HCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHH
QVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELDGQTHTVSWPRTAKLLDVLLAAGLD
HHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHCCC
APFSCREGHCGACACTLRAGKVNMGVNDVLEQQDLDEGLILACQSRPESDSVEVTYDE
CCCCCCCCCCCEEEEEEECCEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036