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The map label for this gene is echA19 [H]

Identifier: 121639434

GI number: 121639434

Start: 3931437

End: 3932228

Strand: Direct

Name: echA19 [H]

Synonym: BCG_3579

Alternate gene names: 121639434

Gene position: 3931437-3932228 (Clockwise)

Preceding gene: 121639432

Following gene: 121639435

Centisome position: 89.87

GC content: 66.67

Gene sequence:

>792_bases
GTGGAATCCGGACCCGACGCGCTGGTGGAGCGGCGCGGCCACACCCTGATCGTGACCATGAACCGGCCGGCCGCCCGCAA
CGCGCTGAGCACCGAAATGATGCGAATCATGGTGCAGGCCTGGGATCGCGTCGACAACGATCCCGACATCCGTTGCTGCA
TCCTCACCGGAGCCGGTGGCTACTTTTGCGCCGGCATGGACCTCAAGGCGGCAACCCAGAAACCGCCGGGCGACTCTTTC
AAGGACGGCAGCTACGACCCGTCGCGCATCGATGCCCTGCTCAAAGGGCGCCGCTTGACCAAACCGCTGATCGCCGCCGT
CGAGGGGCCCGCGATCGCCGGCGGCACCGAGATCCTGCAGGGCACCGACATCCGGGTCGCCGGTGAAAGTGCGAAGTTCG
GCATCTCCGAGGCCAAGTGGAGCCTGTACCCGATGGGCGGCTCGGCCGTGCGGCTGGTCCGGCAGATCCCCTACACTCTG
GCCTGCGACCTGCTGCTGACCGGACGGCACATTACCGCCGCCGAGGCCAAGGAAATGGGCCTGATCGGCCACGTGGTGCC
CGACGGCCAGGCGCTGACCAAGGCTCTAGAACTTGCCGACGCCATCTCGGCTAACGGACCCCTGGCCGTGCAGGCCATCC
TGCGGTCCATCCGCGAGACCGAGTGCATGCCCGAAAACGAGGCGTTCAAGATCGACACCCAGATCGGCATCAAGGTCTTC
CTGTCCGACGACGCCAAGGAAGGCCCGCGCGCGTTCGCCGAGAAGCGCGCACCCAACTTCCAGAACCGCTAG

Upstream 100 bases:

>100_bases
ATCGGCAATATTCAGGGCCACGGCCACCAAACTAGAACGTGTTACATTTCTTGACAAGCTCACACCCGACGGGCAGAAAG
AGGTGGCGGCCGTGGCAACC

Downstream 100 bases:

>100_bases
GCGCCGAGCGTGAACTGAGGGCGAGATTTCGGCCGATTTTCCGCCCTCAGTTCACGTTGGACGGCGGTGTCGGTGCACGA
CGGCACACTGCGATCGTGAT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSF
KDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTL
ACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
LSDDAKEGPRAFAEKRAPNFQNR

Sequences:

>Translated_263_residues
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSF
KDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTL
ACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
LSDDAKEGPRAFAEKRAPNFQNR
>Mature_263_residues
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSF
KDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTL
ACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
LSDDAKEGPRAFAEKRAPNFQNR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=259, Percent_Identity=32.4324324324324, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=33.7209302325581, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI70995211, Length=216, Percent_Identity=34.7222222222222, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI31542718, Length=247, Percent_Identity=25.9109311740891, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI45643119, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI260275230, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI260274832, Length=210, Percent_Identity=29.0476190476191, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI116235487, Length=223, Percent_Identity=26.9058295964126, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4757968, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI49355787, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI25453481, Length=260, Percent_Identity=23.8461538461538, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI51538573, Length=260, Percent_Identity=23.8461538461538, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4757966, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI51538581, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI221136756, Length=227, Percent_Identity=26.8722466960352, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI221136753, Length=227, Percent_Identity=26.8722466960352, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI37594471, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI37594469, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI221307494, Length=227, Percent_Identity=26.8722466960352, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI20127408, Length=195, Percent_Identity=28.7179487179487, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI68989263, Length=188, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787659, Length=258, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=36.046511627907, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87082183, Length=257, Percent_Identity=29.9610894941634, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788597, Length=248, Percent_Identity=28.6290322580645, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787660, Length=250, Percent_Identity=31.2, Blast_Score=94, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=244, Percent_Identity=36.0655737704918, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17554946, Length=255, Percent_Identity=31.7647058823529, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17540714, Length=198, Percent_Identity=35.3535353535354, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560910, Length=246, Percent_Identity=30.4878048780488, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17536985, Length=276, Percent_Identity=25, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17540306, Length=259, Percent_Identity=27.7992277992278, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=227, Percent_Identity=27.7533039647577, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=219, Percent_Identity=28.310502283105, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144160, Length=246, Percent_Identity=30.4878048780488, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25144157, Length=246, Percent_Identity=30.4878048780488, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=33.739837398374, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=33.739837398374, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653139, Length=267, Percent_Identity=32.5842696629214, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24650670, Length=279, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21357171, Length=252, Percent_Identity=30.5555555555556, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920382, Length=233, Percent_Identity=29.6137339055794, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922422, Length=263, Percent_Identity=26.2357414448669, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24654903, Length=197, Percent_Identity=26.3959390862944, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571729, Length=263, Percent_Identity=25.4752851711027, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571730, Length=263, Percent_Identity=25.4752851711027, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28307; Mature: 28307

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGG
CCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
YFCAGMDLKAATQKPPGDSFKDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQ
EEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHC
GTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMG
CCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHEEHEEEECCEEEHHHHHHCC
LIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
EEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEE
LSDDAKEGPRAFAEKRAPNFQNR
ECCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGG
CCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
YFCAGMDLKAATQKPPGDSFKDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQ
EEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHC
GTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMG
CCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHEEHEEEECCEEEHHHHHHCC
LIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVF
EEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEE
LSDDAKEGPRAFAEKRAPNFQNR
ECCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]