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The map label for this gene is fadD17 [H]

Identifier: 121639425

GI number: 121639425

Start: 3904387

End: 3905895

Strand: Direct

Name: fadD17 [H]

Synonym: BCG_3570

Alternate gene names: 121639425

Gene position: 3904387-3905895 (Clockwise)

Preceding gene: 121639424

Following gene: 121639426

Centisome position: 89.25

GC content: 66.4

Gene sequence:

>1509_bases
ATGACTCCCACTCACCCGACCGTCACCGAACTTCTGCTGCCGCTATCCGAAATCGACGATCGGGGCGTCTATTTCGAGGA
CTCGTTCACCAGTTGGCGCGACCACATCCGGCACGGTGCCGCAATCGCCGCAGCGCTGCGGGAACGCCTGGACCCGGCGC
GGCCGCCACACGTCGGTGTGTTACTGCAGAACACGCCGTTCTTCTCGGCGACACTGGTGGCCGGCGCGCTGTCGGGGATC
GTCCCGGTGGGCCTCAACCCGGTGCGCCGCGGCGCGGCACTGGCCGGCGACATCGCTAAAGCCGACTGCCAGTTGGTGCT
CACCGGCTCGGGATCGGCGGAGGTACCGGCCGATGTCGAGCACATCAATGTCGACTCCCCCGAATGGACCGACGAGGTGG
CCGCACACCGGGATACCGAGGTGCGTTTTCGATCCGCGGATCTCGCAGACCTTTTCATGCTGATCTTCACCTCGGGCACC
AGCGGCGACCCGAAGGCGGTGAAGTGCAGCCACCGCAAGGTTGCGATCGCCGGCGTGACGATCACGCAGCGCTTCAGTCT
GGGCCGCGACGACGTCTGCTACGTCTCGATGCCGTTGTTCCATTCCAACGCGGTGCTGGTCGGCTGGGCGGTGGCTGCGG
CCTGCCAAGGCTCAATGGCGTTGCGACGCAAATTTTCGGCGTCGCAGTTCCTGGCCGACGTCCGCCGTTATGGCGCCACT
TACGCCAACTACGTGGGCAAGCCTCTTTCGTATGTGCTTGCGACACCGGAGCTTCCCGACGACGCGGACAACCCGCTGCG
GGCGGTGTACGGCAACGAGGGAGTACCCGGTGACATCGACCGTTTCGGGCGCAGGTTCGGCTGCGTTGTCATGGACGGCT
TCGGCTCGACTGAAGGCGGGGTGGCGATCACGCGGACACTCGACACCCCGGCGGGCGCCCTGGGCCCACTGCCGGGGGGA
ATCCAAATCGTCGACCCCGACACCGGCGAACCGTGCCCGACAGGAGTGGTCGGCGAACTGGTCAACACCGCCGGGCCGGG
CGGTTTCGAAGGCTATTACAACGACGAGGCCGCCGAGGCCGAGCGGATGGCCGGCGGCGTCTACCACAGTGGCGACCTCG
CCTATCGCGACGACGCCGGCTACGCCTATTTCGCCGGTCGGCTCGGCGACTGGATGCGAGTCGACGGTGAAAATCTAGGC
ACCGCACCGATCGAGCGGGTGCTGATGCGCTACCCGGACGCCACCGAGGTCGCTGTGTATCCGGTACCCGATCCGGTGGT
GGGTGATCAGGTGATGGCCGCGTTAGTGTTGGCGCCCGGCACCAAATTCGATGCCGACAAGTTCCGGGCGTTTCTGACCG
AGCAGCCCGACCTGGGGCACAAGCAGTGGCCGTCGTATGTGCGGGTCAGCGCGGGGCTGCCGCGCACCATGACCTTCAAG
GTGATCAAGCGCCAGTTGTCGGCCGAAGGTGTCGCCTGCGCCGATCCGGTGTGGCCGATTCGCCGGTAG

Upstream 100 bases:

>100_bases
GGCCGTGAACTGGCGGAAACCCCTGCCTAGCCCTGCCTAGCCCGGCGACGATGCGGTCCGCGCAGCGGACCGAGAAGGAG
CGGGCGAATCGAACCCACCG

Downstream 100 bases:

>100_bases
CCTCACGGCGCGCCACCATGCTCACCGGGATCTGGCCGGATGGTGGACCCGAATAATCGGGTAGAACCGCCGAATGAGCT
GCCCGGATCGCGATACGATC

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGI
VPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGT
SGDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGAT
YANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGG
IQIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLG
TAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFK
VIKRQLSAEGVACADPVWPIRR

Sequences:

>Translated_502_residues
MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGI
VPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGT
SGDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGAT
YANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGG
IQIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLG
TAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFK
VIKRQLSAEGVACADPVWPIRR
>Mature_501_residues
TPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIV
PVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTS
GDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGATY
ANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGGI
QIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLGT
APIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFKV
IKRQLSAEGVACADPVWPIRR

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=518, Percent_Identity=27.4131274131274, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13325057, Length=374, Percent_Identity=31.283422459893, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI40807357, Length=529, Percent_Identity=27.0321361058601, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI38524616, Length=376, Percent_Identity=31.1170212765957, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI62865631, Length=520, Percent_Identity=26.5384615384615, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI13325055, Length=520, Percent_Identity=26.5384615384615, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI13236579, Length=383, Percent_Identity=30.2872062663185, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI227499621, Length=304, Percent_Identity=29.6052631578947, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI42544132, Length=364, Percent_Identity=26.0989010989011, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI115511026, Length=370, Percent_Identity=25.9459459459459, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI58082049, Length=361, Percent_Identity=25.207756232687, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI157311624, Length=361, Percent_Identity=24.6537396121884, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI157311622, Length=361, Percent_Identity=24.6537396121884, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38505220, Length=430, Percent_Identity=25.3488372093023, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI122937307, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI28416953, Length=515, Percent_Identity=22.7184466019417, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI8923896, Length=400, Percent_Identity=25, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI253970489, Length=400, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI221142682, Length=353, Percent_Identity=26.628895184136, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI145693145, Length=374, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786810, Length=213, Percent_Identity=33.8028169014084, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788107, Length=377, Percent_Identity=24.6684350132626, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=235, Percent_Identity=28.0851063829787, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788595, Length=290, Percent_Identity=26.2068965517241, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786529, Length=220, Percent_Identity=30.4545454545455, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551278, Length=502, Percent_Identity=29.4820717131474, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI115534440, Length=491, Percent_Identity=27.0875763747454, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=482, Percent_Identity=24.896265560166, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=472, Percent_Identity=22.8813559322034, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=366, Percent_Identity=24.5901639344262, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319515, Length=289, Percent_Identity=29.0657439446367, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323182, Length=407, Percent_Identity=27.5184275184275, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=390, Percent_Identity=26.1538461538462, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550496, Length=490, Percent_Identity=27.9591836734694, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45552801, Length=490, Percent_Identity=27.5510204081633, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI20130353, Length=541, Percent_Identity=26.8022181146026, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28573631, Length=541, Percent_Identity=26.8022181146026, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281364798, Length=490, Percent_Identity=27.5510204081633, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24583465, Length=490, Percent_Identity=27.5510204081633, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24583463, Length=490, Percent_Identity=27.5510204081633, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI18859661, Length=500, Percent_Identity=25.4, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24581924, Length=519, Percent_Identity=25.0481695568401, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648260, Length=348, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355181, Length=347, Percent_Identity=23.6311239193084, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24653035, Length=341, Percent_Identity=25.5131964809384, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648257, Length=350, Percent_Identity=24.8571428571429, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281365686, Length=330, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24648255, Length=319, Percent_Identity=24.4514106583072, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356441, Length=431, Percent_Identity=23.6658932714617, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648253, Length=319, Percent_Identity=24.4514106583072, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358303, Length=340, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161076582, Length=348, Percent_Identity=25.2873563218391, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667959, Length=414, Percent_Identity=24.8792270531401, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI62472339, Length=414, Percent_Identity=24.8792270531401, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24667955, Length=415, Percent_Identity=24.8192771084337, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356947, Length=481, Percent_Identity=24.5322245322245, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 53739; Mature: 53608

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGV
CCCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVE
EEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCCE
HINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVT
EECCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEE
ITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGAT
EEEECCCCCCCEEEEEECEECCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCH
YANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGG
HHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCC
VAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEA
EEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
ERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
HHHHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEE
PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFK
ECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHCCCEEEEECCCCCHHHHH
VIKRQLSAEGVACADPVWPIRR
HHHHHHCCCCCEECCCCCCCCC
>Mature Secondary Structure 
TPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGV
CCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
LLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVE
EEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCCE
HINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVT
EECCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEE
ITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGAT
EEEECCCCCCCEEEEEECEECCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCH
YANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGG
HHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEECCCCCCCC
VAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEA
EEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHH
ERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
HHHHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEE
PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFK
ECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHCCCEEEEECCCCCHHHHH
VIKRQLSAEGVACADPVWPIRR
HHHHHHCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA