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The map label for this gene is metX

Identifier: 121639269

GI number: 121639269

Start: 3718772

End: 3719911

Strand: Direct

Name: metX

Synonym: BCG_3411

Alternate gene names: 121639269

Gene position: 3718772-3719911 (Clockwise)

Preceding gene: 121639268

Following gene: 121639270

Centisome position: 85.01

GC content: 69.3

Gene sequence:

>1140_bases
ATGACGATCTCCGATGTACCCACCCAGACGCTGCCCGCCGAAGGCGAAATCGGCCTGATAGACGTCGGCTCGCTGCAACT
GGAAAGCGGGGCGGTGATCGACGATGTCTGTATCGCCGTGCAACGCTGGGGCAAATTGTCGCCCGCACGGGACAACGTGG
TGGTGGTCTTGCACGCGCTCACCGGCGACTCGCACATCACTGGACCCGCCGGACCCGGCCACCCCACCCCCGGCTGGTGG
GACGGGGTGGCCGGGCCGGGTGCGCCGATTGACACCACCCGCTGGTGCGCGGTAGCTACCAATGTGCTCGGCGGCTGCCG
CGGCTCCACCGGGCCCAGCTCGCTTGCCCGCGACGGAAAGCCTTGGGGCTCAAGATTTCCGCTGATCTCGATACGTGACC
AGGTGCAGGCGGACGTCGCGGCGCTGGCCGCGCTGGGCATCACCGAGGTCGCCGCCGTCGTCGGCGGCTCCATGGGCGGC
GCCCGGGCCCTGGAATGGGTGGTCGGCTACCCGGATCGGGTCCGAGCCGGATTGCTGCTGGCGGTCGGTGCGCGTGCCAC
CGCAGACCAGATCGGCACGCAGACAACGCAAATCGCGGCCATCAAAGCCGACCCGGACTGGCAGAGCGGCGACTACCACG
AGACGGGGAGGGCACCAGACGCCGGGCTGCGACTCGCCCGCCGCTTCGCGCACCTCACCTACCGCGGCGAGATCGAGCTC
GACACCCGGTTCGCCAACCACAACCAGGGCAACGAGGATCCGACGGCCGGCGGGCGCTACGCGGTGCAAAGTTATCTGGA
ACACCAAGGAGACAAACTGTTATCCCGGTTCGACGCCGGCAGCTACGTGATTCTCACCGAGGCGCTCAACAGCCACGACG
TCGGCCGCGGCCGCGGCGGGGTCTCCGCGGCTCTGCGCGCCTGCCCGGTGCCGGTGGTGGTGGGCGGCATCACCTCCGAC
CGGCTCTACCCGCTGCGCCTGCAGCAGGAGCTGGCCGACCTGCTGCCGGGCTGCGCCGGGCTGCGAGTCGTCGAGTCGGT
CTACGGACACGACGGCTTCCTGGTGGAAACCGAGGCCGTGGGCGAATTGATCCGCCAGACACTGGGATTGGCTGATCGTG
AAGGCGCGTGTCGGCGGTGA

Upstream 100 bases:

>100_bases
GTATCGACGATATCCTGGCCGACCTGGAGCTTGGCTTTGCCGCGGCCCGCAGATTCAGCGCCGACCCGCAGTCCGTGGCG
GCGTTCTGAGGAATTCTGAC

Downstream 100 bases:

>100_bases
CGTGCTCCCGACGCGACATGTCCCTGTCGTTTGGCTCCGCGGTCGGCGCCTACGAGCGCGGGCGCCCCTCGTATCCACCG
GAAGCCATCGACTGGCTGCT

Product: homoserine O-acetyltransferase

Products: NA

Alternate protein names: Homoserine O-trans-acetylase; HTA; Homoserine transacetylase

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWW
DGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGG
ARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIEL
DTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSD
RLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR

Sequences:

>Translated_379_residues
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWW
DGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGG
ARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIEL
DTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSD
RLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR
>Mature_378_residues
TISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWD
GVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGA
RALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELD
TRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDR
LYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR

Specific function: Unknown

COG id: COG2021

COG function: function code E; Homoserine acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HTA family

Homologues:

Organism=Saccharomyces cerevisiae, GI6324052, Length=229, Percent_Identity=35.8078602620087, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METX_MYCBO (P0A5J9)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_857018.1
- ProteinModelPortal:   P0A5J9
- EnsemblBacteria:   EBMYCT00000014587
- GeneID:   1093427
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3373
- GeneTree:   EBGT00050000016704
- HOGENOM:   HBG692920
- OMA:   VSFTSDW
- ProtClustDB:   PRK00175
- BioCyc:   MBOV233413:MB3373-MONOMER
- BRENDA:   2.3.1.31
- GO:   GO:0005737
- HAMAP:   MF_00296
- InterPro:   IPR000073
- InterPro:   IPR008220
- PIRSF:   PIRSF000443
- TIGRFAMs:   TIGR01392

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =2.3.1.31

Molecular weight: Translated: 39769; Mature: 39638

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: ACT_SITE 157-157 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHAL
CCCCCCCCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEE
TGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCC
PWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLL
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCEEE
AVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIEL
EECCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECEEEE
DTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGG
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAV
HHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHH
GELIRQTLGLADREGACRR
HHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHAL
CCCCCCCCCCCCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEE
TGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCC
PWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLL
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCEEE
AVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIEL
EECCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECEEEE
DTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGG
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCC
VSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAV
HHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHH
GELIRQTLGLADREGACRR
HHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972