Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 121639242

GI number: 121639242

Start: 3693571

End: 3695343

Strand: Direct

Name: sdhA [H]

Synonym: BCG_3384

Alternate gene names: 121639242

Gene position: 3693571-3695343 (Clockwise)

Preceding gene: 121639241

Following gene: 121639243

Centisome position: 84.43

GC content: 65.31

Gene sequence:

>1773_bases
TTGATCTGCCAACACCGATACGACGTGGTGATCGTCGGCGCGGGCGGTGCCGGGATGCGCGCCGCGGTCGAGGCGGGTCC
GCGGGTGCGTACCGCGGTACTGACCAAGCTGTATCCCACCCGCAGCCACACCGGCGCGGCCCAGGGCGGCATGTGCGCCG
CGCTGGCCAACGTCGAGGACGACAACTGGGAGTGGCACACGTTCGACACCGTCAAGGGCGGCGACTATCTCGCCGACCAG
GACGCCGTGGAGATCATGTGCAAGGAAGCCATCGACGCGGTGCTCGACCTGGAGAAGATGGGGATGCCGTTCAACCGCAC
CCCCGAGGGCCGCATCGACCAGCGCCGCTTCGGCGGGCACACCCGCGACCACGGCAAGGCCCCGGTGCGCCGGGCCTGCT
ACGCGGCCGATCGCACCGGCCACATGATTCTGCAGACGCTGTATCAGAACTGCGTCAAGCACGACGTCGAGTTCTTCAAC
GAATTTTACGCGCTGGATTTGGCTTTGACTCAAACGCCGTCGGGCCCGGTGGCCACCGGGGTGATCGCCTACGAGCTAGC
GACCGGTGACATCCATGTCTTTCACGCCAAGGCCGTCGTGATCGCGACCGGCGGCTCGGGCCGCATGTATAAGACCACGT
CCAACGCACACACCCTGACCGGCGACGGCATCGGCATCGTGTTCCGCAAGGGACTTCCCTTGGAGGACATGGAGTTTCAC
CAGTTTCACCCTACCGGCCTGGCCGGTCTGGGCATCTTAATCTCCGAAGCGGTGCGCGGCGAAGGCGGCCGGCTGCTCAA
CGGGGAAGGTGAGCGTTTCATGGAGCGCTACGCCCCGACGATCGTCGACCTAGCGCCCCGCGACATCGTCGCCCGCTCGA
TGGTGCTGGAAGTGCTGGAGGGACGCGGCGCCGGACCGCTCAAGGACTACGTCTACATCGACGTCCGCCACCTGGGCGAG
GAAGTGCTCGAGGCCAAGCTGCCCGACATCACCGAGTTCGCCCGCACCTACCTGGGCGTGGATCCGGTCACCGAGCTGGT
GCCGGTCTACCCGACGTGCCACTACCTGATGGGCGGCATCCCGACCACAGTCACCGGGCAGGTGCTGCGGGACAACACCA
GCGTTGTCCCGGGCCTGTATGCGGCCGGCGAGTGCGCGTGCGTGTCGGTGCATGGCGCCAACCGGCTGGGCACCAACTCG
CTGTTGGATATCAACGTCTTCGGTCGTCGGGCCGGCATCGCCGCCGCCAGTTATGCGCAGGGTCACGACTTTGTCGACAT
GCCGCCCAACCCGGAGGCCATGGTGGTGGGCTGGGTCAGCGACATCCTGTCCGAACACGGAAACGAGCGGGTCGCCGACA
TTCGCGGGGCGCTGCAGCAGTCGATGGACAACAACGCCGCGGTGTTCCGCACCGAGGAGACCCTGAAGCAGGCGCTCACC
GACATCCACGCGCTCAAGGAGCGCTACTCCCGAATCACGGTGCACGACAAGGGGAAACGCTTCAACACCGACCTGCTGGA
AGCCATCGAGCTGGGATTTTTACTGGAGCTGGCCGAGGTCACGGTGGTCGGCGCTTTGAATCGCAAGGAGTCCCGCGGCG
GTCACGCCCGCGAGGACTATCCCAACCGCGACGACGTCAACTACATGCGACACACCATGGCCTACAAGGAAATTGGGGCC
GATAAGGAGGGCCCCGAGCTGCGCAGCGATGTCCGCCTTGATTTCAAACCCGTCGTGCAGACCCGTTACGAACCCAAGGA
ACGGAAGTACTAA

Upstream 100 bases:

>100_bases
CACCTCTCCCCCGCAAGCGGGCGGTACCCCCACCTCATCGCTGCGGCCCCCTCGTCGCTTCGCGGCTGGGGGTGCCCCCA
CTGCATCGTCGGCGGCGGCG

Downstream 100 bases:

>100_bases
TGAGCGTCGAGCCGGACGTCGAAACTTTGGATCCGCCCCTACCGCCGGTACCGGACGGCGCGGTGATGGTGACCGTCAAG
ATCGCCCGGTTCAACCCCGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGE
EVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGA
DKEGPELRSDVRLDFKPVVQTRYEPKERKY

Sequences:

>Translated_590_residues
MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGE
EVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGA
DKEGPELRSDVRLDFKPVVQTRYEPKERKY
>Mature_590_residues
MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQ
DAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGE
EVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNS
LLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGA
DKEGPELRSDVRLDFKPVVQTRYEPKERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=578, Percent_Identity=47.5778546712803, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786942, Length=568, Percent_Identity=48.7676056338028, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=39.4463667820069, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=33.3935018050542, Blast_Score=227, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=581, Percent_Identity=46.815834767642, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17505833, Length=582, Percent_Identity=45.360824742268, Blast_Score=499, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=47.8187919463087, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322416, Length=570, Percent_Identity=50.1754385964912, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=27.8688524590164, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=46.6887417218543, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=46.6887417218543, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=46.6887417218543, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24663005, Length=560, Percent_Identity=47.3214285714286, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64826; Mature: 64826

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVED
CCCCEECCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLALTQTPSGPVATG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEC
VIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCC
PTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAASYAQ
CCHHCCHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHCC
GHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PNRDDVNYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCCHHCCC
>Mature Secondary Structure
MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVED
CCCCEECCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCC
DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLALTQTPSGPVATG
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCEEC
VIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH
EEEEEEECCCEEEEEEEEEEEEECCCCCEEEECCCCEEECCCCEEEEEECCCCCCCCCCC
QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLE
CCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHEECCCHHHHHHHHHHHHHH
GRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGI
CCCCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCC
PTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAASYAQ
CCHHCCHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHCC
GHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT
CCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY
HHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCC
PNRDDVNYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA