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The map label for this gene is nuoN

Identifier: 121639041

GI number: 121639041

Start: 3478837

End: 3480432

Strand: Direct

Name: nuoN

Synonym: BCG_3181

Alternate gene names: 121639041

Gene position: 3478837-3480432 (Clockwise)

Preceding gene: 121639040

Following gene: 121639052

Centisome position: 79.52

GC content: 65.48

Gene sequence:

>1596_bases
ATGATCCTGCCCGCCCCGCACGTCGAGTACTTCCTGCTCGCTCCGATGCTCATCGTCTTTTCGGTTGCGGTCGCCGGTGT
GCTGGCCGAGGCTTTCCTGCCGCGCCGGTGGCGCTATGGCGCCCAAGTGACGCTCGCCCTTGGCGGGTCGGCAGTGGCAC
TCATCGCGGTCATCGTGGTGGCCAGGTCGATTCACGGGTCGGGTCACGCCGCGGTGCTGGGGGCCATAGCCGTGGATCGA
GCGACCCTGTTTCTGCAAGGCACCGTACTACTGGTCACGATCATGGCAGTCGTCTTCATGGCCGAACGCAGCGCCCGGGT
GAGTCCGCAACGCCAGAACACCCTCGCTGTGGCGCGGCTCCCTGGACTCGATTCGTTTACCCCGCAGGCTTCCGCCGTGC
CCGGCAGCGATGCTGAGCGCCAAGCGGAACGGGCGGGAGCCACCCAGACGGAACTTTTCCCGCTGGCGATGCTGTCCGTC
GGCGGCATGATGGTGTTTCCCGCGTCCAACGACCTGTTGACGATGTTCGTTGCGCTGGAGGTGCTATCGCTGCCGCTGTA
CCTGATGTGTGGGCTGGCCCGGAATCGCCGCCTGCTGTCGCAGGAAGCCGCGATGAAGTACTTCCTGCTGGGCGCCTTCT
CGTCGGCGTTCTTCCTCTACGGCGTCGCGTTGCTATACGGCGCGACCGGCACGCTGACCTTGCCGGGTATTCGGGATGCG
TTGGCAGCGCGCACCGACGACTCAATGGCGTTGGCCGGCGTCGCGCTGCTCGCGGTCGGCCTACTATTCAAGGTCGGCGC
GGTGCCATTCCACTCCTGGATTCCCGATGTGTACCAGGGCGCACCCACCCCGATCACCGGGTTCATGGCGGCCGCCACCA
AGGTCGCGGCGTTCGGTGCGCTGCTCCGGGTGGTCTATGTCGCGCTGCCGCCGCTGCACGATCAGTGGCGCCCGGTGCTG
TGGGCGATTGCCATCCTCACCATGACGGTGGGCACCGTCACCGCGGTAAACCAGACCAACGTCAAGCGTATGCTGGCCTA
TTCATCGGTCGCGCACGTCGGTTTCATACTTACCGGCGTGATCGCCGATAATCCGGCGGGTCTTTCCGCGACGTTGTTCT
ATCTGGTCGCCTACAGCTTCAGCACGATGGGTGCGTTTGCCATCGTGGGTCTGGTCCGAGGCGCCGACGGCTCAGCAGGT
TCAGAGGATGCCGACCTGTCCCACTGGGCCGGGCTGGGACAGCGTTCACCTATCGTGGGCGTGATGCTGTCGATGTTTCT
GCTGGCCTTCGCCGGCATCCCGTTGACCAGTGGATTCGTCAGCAAGTTCGCGGTGTTTAGGGCCGCCGCTTCCGCCGGCG
CGGTGCCGCTGGTAATCGTCGGCGTGATCTCCAGCGGCGTCGCCGCCTACTTCTACGTGCGGGTGATCGTGAGCATGTTC
TTCACCGAAGAATCCGGTGACACACCACACGTGGCGGCACCCGGCGTGCTGAGCAAGGCCGCCATTGCGGTATGCACGGT
AGTCACCGTGGTGCTGGGGATCGCCCCGCAGCCGGTGCTCGACCTGGCCGACCAGGCCGCCCAGTTGCTGCGCTGA

Upstream 100 bases:

>100_bases
AGAACACCATGACCACCATCGGCCAGCATGATCCCGCGCCCAGCGTGGCACACCCGGTTCCGGCCGTGGGCGCCTCCCGG
ACAGCCGAAGGACCGCACCC

Downstream 100 bases:

>100_bases
ATCCGTTAGGGCTGACCGAAGAAGCCCGACTGGTCACTGCCCTGATTGAAGCCCCCCGAGCTGTGGTCACCCGTGTTCGC
CACACCCGTGTTGAGGGTGC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDR
ATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSV
GGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA
LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVL
WAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAG
SEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF
FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR

Sequences:

>Translated_531_residues
MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDR
ATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSV
GGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA
LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVL
WAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAG
SEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF
FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
>Mature_531_residues
MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDR
ATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSV
GGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA
LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVL
WAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAG
SEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF
FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=280, Percent_Identity=24.6428571428571, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI145693160, Length=402, Percent_Identity=35.3233830845771, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1788831, Length=317, Percent_Identity=25.8675078864353, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788614, Length=345, Percent_Identity=24.6376811594203, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788613, Length=383, Percent_Identity=24.5430809399478, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788827, Length=404, Percent_Identity=23.5148514851485, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=402, Percent_Identity=24.3781094527363, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788829, Length=324, Percent_Identity=24.6913580246914, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_MYCBO (P0A5M1)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856827.1
- ProteinModelPortal:   P0A5M1
- EnsemblBacteria:   EBMYCT00000016769
- GeneID:   1093748
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3182
- GeneTree:   EBGT00050000015714
- HOGENOM:   HBG747830
- OMA:   MDMNTLL
- ProtClustDB:   PRK05777
- BioCyc:   MBOV233413:MB3182-MONOMER
- BRENDA:   1.6.99.5
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 55343; Mature: 55343

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18dee5f4)-; HASH(0x187c7aa4)-; HASH(0x18b5bd48)-; HASH(0x186a6c1c)-; HASH(0x17c6cf04)-; HASH(0x182456e4)-; HASH(0x18414fcc)-; HASH(0x18ae5fdc)-; HASH(0x187d7d28)-; HASH(0x18e224ac)-; HASH(0x1537dc40)-; HASH(0x1875ecf8)-; HASH(0x185d70d0)-; HASH(0x1832edac)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECCHHHHHHHHHHH
ARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEC
PGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALE
CCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
VLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHH
LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHH
LLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
IADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHH
VMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCH
>Mature Secondary Structure
MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECCHHHHHHHHHHH
ARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEC
PGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALE
CCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
VLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHH
LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHH
LLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
IADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHH
VMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972