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The map label for this gene is nuoL

Identifier: 121639039

GI number: 121639039

Start: 3475281

End: 3477182

Strand: Direct

Name: nuoL

Synonym: BCG_3179

Alternate gene names: 121639039

Gene position: 3475281-3477182 (Clockwise)

Preceding gene: 121639038

Following gene: 121639040

Centisome position: 79.44

GC content: 65.51

Gene sequence:

>1902_bases
GTGACAACTTCCTTGGGGACTCACTACACCTGGCTGCTGGTGGCACTGCCACTGGCGGGTGCCGCAATCTTGCTGTTCGG
CGGCAGACGCACCGATGCGTGGGGCCACCTGCTGGGCTGTGCCGCAGCGCTGGCGGCATTCGGGGTGGGCGCGATGCTGC
TGGCCGACATGCTCGGTCGCGATGGGCTCGAGCGCGCGATCCATCAGCAGGTGTTCACCTGGATACCCGCCGGCGGACTC
CAAGTCGACTTCGGGCTGCAGATCGATCAGTTGTCCATGTGCTTCGTGCTGCTGATCTCCGGGGTCGGATCGCTGATTCA
CATCTATTCGGTCGGCTACATGGCCGAGGACCCGGACCGGCGCAGGTTTTTCGGCTATCTCAACCTGTTTCTGGCCTCGA
TGCTGCTGCTGGTGGTCGCCGACAACTATGTGTTGCTGTACGTCGGCTGGGAGGGTGTGGGCCTGGCGTCGTATCTGTTG
ATCGGTTTCTGGTACCACAAGCCGTCGGCGGCCACCGCGGCCAAAAAGGCATTCGTGATGAACCGGGTTGGGGACGCCGG
CCTAGCGGTGGGTATGTTCTTGACGTTTAGCACTTTCGGCACCCTGTCGTATGCCGGCGTGTTCGCCGGCGTACCCGCCG
CAAGTCGCGCAGTGCTGACCGCGATCGGGTTGTTGATGCTGTTGGGGGCGTGCGCCAAGTCCGCGCAGGTTCCGCTGCAA
GCCTGGCTTGGCGACGCGATGGAGGGCCCCACCCCGGTGTCCGCGCTGATCCACGCCGCCACCATGGTGACCGCCGGAGT
GTATTTGATTGTGCGGTCGGGCCCGCTGTACAACCTGGCGCCCACCGCCCAACTGGCGGTCGTCATCGTCGGCGCGGTGA
CGCTGCTGTTTGGGGCGATCATCGGCTGCGCCAAGGACGACATCAAACGTGCGCTGGCAGCCTCGACCATTAGCCAGATC
GGCTACATGGTGCTGGCCGCGGGCCTGGGTCCGGCCGGCTACGCGTTTGCGATCATGCATCTGCTCACTCACGGTTTCTT
CAAGGCCGGCCTATTCCTTGGGTCCGGCGCGGTGATTCACGCGATGCACGAAGAGCAGGACATGCGCCGTTACGGTGGTC
TGCGCGCCGCCCTGCCGGTCACGTTCGCAACCTTCGGCCTGGCGTATCTGGCGATTATCGGGGTACCGCCGTTCGCGGGC
TTCTTCTCCAAGGATGCGATCATCGAGGCCGCATTGGGCGCCGGCGGCATCCGGGGCTCGCTGCTGGGCGGTGCCGCGCT
GCTGGGTGCGGGCGTCACCGCGTTCTACATGACGCGAGTGATGCTGATGACCTTCTTCGGCGAAAAGCGTTGGACGCCAG
GCGCCCATCCGCACGAGGCACCGGCCGTGATGACCTGGCCGATGATCTTGCTCGCCGTCGGCTCGGTGTTCTCCGGTGGC
CTGCTCGCGGTGGGTGGCACGTTGCGGCATTGGCTGCAGCCAGTTGTCGGATCTCATGAAGAGGCCACCCATGCGCTGCC
GACCTGGGTCGCCACCACCCTGGCGCTCGGTGTGGTCGCCGTCGGTATCGCGGTGGCCTACCGGATGTACGGCACCGCGC
CGATCCCGAGGGTTGCCCCGGTTCGGGTGTCGGCGCTGACCGCGGCCGCACGTGCGGACCTGTACGGCGATGCCTTCAAC
GAGGAGGTGTTCATGCGCCCTGGTGCGCAATTGACCAACGCGGTGGTCGCGGTGGACGACGCGGGTGTGGACGGCTCGGT
TAACGCGCTGGCGACGCTCGTGAGCCAGACTTCGAATCGCCTGCGGCAAATGCAAACCGGCTTCGCCCGTAACTACGCGT
TATCGATGCTGGTAGGAGCGGTGTTAGTGGCGGCGGCGCTGCTGGTGGTGCAGCTGTGGTGA

Upstream 100 bases:

>100_bases
GAAGTGGTCGTCGGCCTGGCCATCATCATGACGATTTTCCGTACCCGCAAATCGGCGTCGGTCGACGACGCGAATCTACT
CAAAGGCTGACGACGCCACC

Downstream 100 bases:

>100_bases
ATAACGTGCCGTGGCTGAGCGTGCTCTGGCTGGTGCCGCTGGCAGGTGCGGTGCTGATCATCCTGCTACCACCCGGTCGG
CGCCGACTCGCCAAGTGGGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGL
QVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLL
IGFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQ
AWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQI
GYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAG
FFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGG
LLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFN
EEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW

Sequences:

>Translated_633_residues
MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGL
QVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLL
IGFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQ
AWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQI
GYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAG
FFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGG
LLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFN
EEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW
>Mature_632_residues
TTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQ
VDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLI
GFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQA
WLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQIG
YMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAGF
FSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGGL
LAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNE
EVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family

Homologues:

Organism=Homo sapiens, GI251831117, Length=412, Percent_Identity=38.1067961165049, Blast_Score=278, Evalue=1e-74,
Organism=Escherichia coli, GI1788614, Length=623, Percent_Identity=39.9678972712681, Blast_Score=347, Evalue=2e-96,
Organism=Escherichia coli, GI1788829, Length=409, Percent_Identity=32.518337408313, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI1788827, Length=464, Percent_Identity=30.3879310344828, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788831, Length=358, Percent_Identity=31.8435754189944, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788613, Length=348, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI2367154, Length=440, Percent_Identity=23.6363636363636, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI145693160, Length=387, Percent_Identity=25.3229974160207, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOL_MYCTU (O86350)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   B70946
- RefSeq:   NP_217672.1
- RefSeq:   NP_337769.1
- ProteinModelPortal:   O86350
- EnsemblBacteria:   EBMYCT00000003746
- EnsemblBacteria:   EBMYCT00000070847
- GeneID:   888063
- GeneID:   923350
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3244
- KEGG:   mtu:Rv3156
- TIGR:   MT3244
- TubercuList:   Rv3156
- GeneTree:   EBGT00050000015714
- HOGENOM:   HBG643593
- OMA:   TVSQIGY
- ProtClustDB:   PRK06590
- BRENDA:   1.6.99.5
- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393
- PRINTS:   PR01435
- TIGRFAMs:   TIGR01974

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N

EC number: =1.6.99.5

Molecular weight: Translated: 66169; Mature: 66037

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x181ad8c4)-; HASH(0x1780ab70)-; HASH(0x18df0bd8)-; HASH(0x18aa2be8)-; HASH(0x18de9144)-; HASH(0x18dee3f0)-; HASH(0x138e18bc)-; HASH(0x18dee3a8)-; HASH(0x1611745c)-; HASH(0x18deba1c)-; HASH(0x17e2a138)-; HASH(0x18debb30)-; HASH(0x18de9090)-; HASH(0x18dee480)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGR
CCCCCCCHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDR
CHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGFWYHKPSAATAAKKAFVM
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
NRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAI
HHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
IGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
AMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAGFFSKDAIIEAALGAGGIRGS
EHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHH
LLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNR
CHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHH
LRQMQTGFARNYALSMLVGAVLVAAALLVVQLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGR
CCCCCCHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDR
CHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
RRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGFWYHKPSAATAAKKAFVM
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
NRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAI
HHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
IGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
AMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAGFFSKDAIIEAALGAGGIRGS
EHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHH
LLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNR
CHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHH
LRQMQTGFARNYALSMLVGAVLVAAALLVVQLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036