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The map label for this gene is nuoH

Identifier: 121639035

GI number: 121639035

Start: 3472329

End: 3473561

Strand: Direct

Name: nuoH

Synonym: BCG_3175

Alternate gene names: 121639035

Gene position: 3472329-3473561 (Clockwise)

Preceding gene: 121639034

Following gene: 121639036

Centisome position: 79.38

GC content: 61.72

Gene sequence:

>1233_bases
ATGACCACGTTCGGCCACGACACCTGGTGGCTGGTGGCGGCCAAAGCGATCGCGGTATTCGTGTTCCTCATGCTGACGGT
GCTGGTGGCGATCCTGGCCGAACGCAAGCTGCTGGGCCGGATGCAGTTGCGGCCCGGCCCCAACCGGGTTGGCCCAAAAG
GAGCCCTGCAGAGCCTGGCTGACGGCATCAAGCTGGCGCTCAAAGAGAGCATCACACCCGGTGGCATCGATCGATTCGTA
TATTTTGTGGCGCCGATCATTTCGGTGATTCCGGCATTCACCGCTTTCGCGTTCATCCCGTTTGGTCCCGAGGTGTCGGT
GTTTGGCCACCGGACACCGTTGCAGATAACCGACCTTCCCGTCGCCGTGCTGTTCATCCTGGGACTGTCGGCGATCGGGG
TATACGGCATCGTGCTGGGCGGTTGGGCGTCCGGGTCCACCTACCCGCTGCTGGGCGGGGTGCGCTCCACCGCGCAGGTC
ATCTCCTACGAGGTCGCGATGGGCCTGTCGTTCGCGACGGTGTTCCTTATGGCCGGCACCATGTCGACGTCGCAGATCGT
GGCCGCACAAGACGGTGTCTGGTATGCCTTCCTGTTGTTGCCGTCATTCGTCATCTATCTCATTTCTATGGTGGGTGAAA
CCAACCGGGCGCCGTTCGATTTGCCCGAAGCCGAGGGCGAGCTGGTCGCGGGATTCCACACCGAGTACTCGTCGTTGAAG
TTCGCGATGTTCATGCTCGCCGAGTACGTCAATATGACTACGGTTTCGGCACTGGCCGCGACCCTATTCTTCGGTGGCTG
GCATGCTCCCTGGCCGCTGAACATGTGGGCGAGCGCCAACACCGGCTGGTGGCCACTGATCTGGTTCACCGCTAAAGTGT
GGGGCTTTCTGTTCATCTATTTCTGGCTGCGGGCTACGCTGCCGCGGCTGCGCTACGACCAGTTCATGGCGCTGGGCTGG
AAGTTATTGATCCCCGTCTCGCTGGTGTGGGTGATGGTCGCCGCGATCATCCGCTCACTACGCAACCAGGGCTACCAGTA
CTGGACCCCGACTCTGGTGTTTAGCAGCATTGTCGTTGCCGCTGCCATGGTGCTGTTGTTGCGAAAGCCGTTGAGCGCTC
CCGGCGCTCGCGCATCGGCACGGCAACGCGGGGACGAAGGCACCAGCCCTGAACCGGCATTTCCGACACCACCGCTGCTA
GCCGGTGCAACCAAGGAGAATGCAGGTGGCTAA

Upstream 100 bases:

>100_bases
GCGAGCGCGCGTGTTCCCCCGCAAGCGGGAGGTGCCCCCAGTACGCCGACACACCGATTTTGATGTACCAGTGCGGACCC
TCGCGCAAGGAGTGGCGGCC

Downstream 100 bases:

>100_bases
CACTGATCGTCCGGCTCTCCCCCACAAGCGGGCGGTACCCCCATCTCGGGCTGACTCCGGCCCGCGTCGTCGCCGGACTA
AGTTACTGGACGCCGTAGCC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDRFV
YFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQV
ISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLK
FAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGW
KLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLL
AGATKENAGG

Sequences:

>Translated_410_residues
MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDRFV
YFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQV
ISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLK
FAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGW
KLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLL
AGATKENAGG
>Mature_409_residues
TTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDRFVY
FVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVI
SYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKF
AMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWK
LLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLA
GATKENAGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=302, Percent_Identity=36.7549668874172, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1788618, Length=328, Percent_Identity=39.0243902439024, Blast_Score=231, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_MYCBO (P65562)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856821.1
- EnsemblBacteria:   EBMYCT00000017683
- GeneID:   1092700
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3176
- GeneTree:   EBGT00050000015877
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- ProtClustDB:   PRK06076
- BioCyc:   MBOV233413:MB3176-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 44658; Mature: 44527

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18807e0c)-; HASH(0x18932170)-; HASH(0x188c3a64)-; HASH(0x188f9f98)-; HASH(0x188f9e30)-; HASH(0x17a8de94)-; HASH(0x1850d44c)-; HASH(0x1893f2c4)-; HASH(0x17b94fbc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCEECHHH
VAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLMAGT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHH
FAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHH
AAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG
HHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
TTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCEECHHH
VAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLMAGT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHH
FAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHH
AAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG
HHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972