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The map label for this gene is yeaE [C]

Identifier: 121638179

GI number: 121638179

Start: 2546177

End: 2547148

Strand: Direct

Name: yeaE [C]

Synonym: BCG_2314

Alternate gene names: 121638179

Gene position: 2546177-2547148 (Clockwise)

Preceding gene: 121638178

Following gene: 121638182

Centisome position: 58.2

GC content: 66.26

Gene sequence:

>972_bases
ATGAAATATCTGGACGTCGACGGAATCGGACAGGTCAGCCGGATCGGGTTGGGCACTTGGCAGTTCGGCTCGCGTGAATG
GGGATATGGGGACCGGTACGCCACCGGCGCCGCCCGCGACATTGTCAAACGCGCACGCGCCTTGGGGGTCACGCTGTTCG
ATACCGCCGAGATCTACGGCCTGGGCAAAAGCGAGCGTATTCTCGGGGAGGCCCTCGGCGACGACCGCACCGAGGTGGTG
GTGGCTAGCAAGGTCTTCCCGGTCGCGCCGTTTCCGGCGGTGATCAAGAACCGCGAGCGCGCCAGTGCGCGGCGGCTGCA
GCTGAACCGTATCCCGCTGTATCAGATCCACCAGCCCAACCCGGTGGTCCCCGATTCGGTGATCATGCCGGGGATGCGTG
ACCTGCTGGACAGCGGCGACATTGGCGCGGCCGGTGTCTCCAACTACTCACTGGCGCGATGGCGGAAGGCCGACGCCGCG
CTTGGGCGCCCAGTCGTCAGCAACCAGGTACATTTCTCGCTCGCCCACCCTGATGCGCTCGAAGATCTGGTGCCGTTCGC
CGAGCTCGAGAACCGCATCGTGATCGCCTACAGCCCGCTGGCGCAAGGACTATTGGGTGGCAAGTACGGACTCGAGAATC
GTCCCGGTGGCGTGCGCGCGTTGAACCCGCTGTTCGGCACCGAGAACCTGCGCCGGATAGAGCCGCTGCTGGCTACGTTG
CGCGCCATCGCCGTCGACGTCGACGCCAAGCCCGCCCAGGTGGCACTGGCCTGGCTGATTAGCCTGCCGGGGGTGGTCGC
CATTCCCGGAGCGTCCAGTGTCGAGCAACTCGAGTTCAACGTCGCGGCCGCTGACATCGAGCTCAGCGCGCAATCCCGCG
ACGCGCTCACCGACGCCGCCCGGGCGTTTCGCCCGGTTTCCACCGGCCGCTTCCTCACCGACATGGTGCGTGAGAAGGTC
AGCCGTCGTTGA

Upstream 100 bases:

>100_bases
GCGAGTGACCAACGGTCTGCGAAATTACCGGCTCGGGGTCGGCTACACCGTCGAGCGACGCGGTCGCCGCCGCGCCGAGC
CCCTCGGTACGGTGGCAGAC

Downstream 100 bases:

>100_bases
GCTCGCTACAAGGTACGCGCGAGACGTTCGGCCAGCAGCTCGGCGAACCTCGCCGGATCCTCGAGTGCGCCGCCTTCGGC
GAGAAGCGCTGTGCCGTAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVV
VASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAA
LGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKV
SRR

Sequences:

>Translated_323_residues
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVV
VASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAA
LGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKV
SRR
>Mature_323_residues
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVV
VASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAA
LGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKV
SRR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family

Homologues:

Organism=Homo sapiens, GI27436969, Length=300, Percent_Identity=27.6666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4504825, Length=300, Percent_Identity=27.6666666666667, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI27436964, Length=312, Percent_Identity=28.525641025641, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI27436971, Length=312, Percent_Identity=28.2051282051282, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI27436966, Length=301, Percent_Identity=28.2392026578073, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI27436962, Length=312, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI223718702, Length=269, Percent_Identity=28.6245353159851, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1788081, Length=319, Percent_Identity=31.3479623824451, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87081735, Length=296, Percent_Identity=32.0945945945946, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788070, Length=316, Percent_Identity=28.4810126582279, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789375, Length=300, Percent_Identity=29.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789199, Length=328, Percent_Identity=28.9634146341463, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994888, Length=311, Percent_Identity=25.08038585209, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566692, Length=291, Percent_Identity=23.3676975945017, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=316, Percent_Identity=23.7341772151899, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644950, Length=344, Percent_Identity=27.3255813953488, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2298_MYCTU (P63484)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   F70733
- RefSeq:   NP_216814.1
- RefSeq:   NP_336826.1
- ProteinModelPortal:   P63484
- SMR:   P63484
- EnsemblBacteria:   EBMYCT00000000223
- EnsemblBacteria:   EBMYCT00000069728
- GeneID:   887344
- GeneID:   924066
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2355
- KEGG:   mtu:Rv2298
- TIGR:   MT2355
- TubercuList:   Rv2298
- GeneTree:   EBGT00050000017290
- HOGENOM:   HBG605727
- OMA:   KIMPVAP
- ProtClustDB:   CLSK872044
- InterPro:   IPR001395
- InterPro:   IPR023210
- Gene3D:   G3DSA:3.20.20.100
- PANTHER:   PTHR11732

Pfam domain/function: PF00248 Aldo_ket_red; SSF51430 Aldo/ket_red

EC number: NA

Molecular weight: Translated: 34987; Mature: 34987

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: ACT_SITE 59-59

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYG
CCEECCCCCCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECHHHEE
LGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPN
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHEECCCCCEEEECCCC
PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDAL
CCCCCHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCEEEEECCCHHH
EDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
HHHHCHHHHCCCEEEEECHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHH
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAA
HHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHEEEEEEEEEEECCCHHHHHHHHH
RAFRPVSTGRFLTDMVREKVSRR
HHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYG
CCEECCCCCCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECHHHEE
LGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPN
CCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCHHHHHHHEECCCCCEEEECCCC
PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDAL
CCCCCHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCEEEEECCCHHH
EDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
HHHHCHHHHCCCEEEEECHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHH
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAA
HHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHEEEEEEEEEEECCCHHHHHHHHH
RAFRPVSTGRFLTDMVREKVSRR
HHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036