Click here to switch to the map view.

The map label for this gene is 121638133

Identifier: 121638133

GI number: 121638133

Start: 2503346

End: 2503915

Strand: Reverse

Name: 121638133

Synonym: BCG_2268c

Alternate gene names: NA

Gene position: 2503915-2503346 (Counterclockwise)

Preceding gene: 121638137

Following gene: 121638132

Centisome position: 57.24

GC content: 65.79

Gene sequence:

>570_bases
ATGCTGTCAATGAGTAATGACCGCGCGGATACCGGTGGTCGTATCCTGCGGGCAGCGGCGAGCTGCGTCGTCGATTACGG
CGTGGACCGGGTGACACTTGCCGAGATCGCCCGGCGCGCGGGCGTGAGCCGCCCGACCGTATACCGTCGCTGGCCGGACA
CCCGGTCGATCATGGCGTCCATGCTGACCAGCCATATCGCCGACGTGCTGCGGGAGGTGCCCCTCGACGGGGACGACCGG
GAAGCGTTGGTAAAGCAGATTGTCGCGGTGGCCGACCGGTTGCGGGGTGACGATCTGATCATGTCGGTCATGCACTCGGA
GCTGGCCAGGGTGTACATCACCGAGCGCCTCGGCACCAGCCAGCAGGTCCTGATCGAGGGGTTGGCCGCCCGGCTGACAG
TGGCGCAGCGGTCGGGCAGTGTGCGCTCCGGCGACGCTCGTCGACTGGCGACCATGGTGTTGCTGATCGCCCAGTCGACC
ATCCAGTCCGCGGACATCGTCGATTCGATCCTCGATTCCGCCGCGCTGGCCACCGAACTTACCCACGCACTGAACGGATA
TTTGTGCTGA

Upstream 100 bases:

>100_bases
CCATCAGAAAGTGGCTTGGCCGCGGCGGGATCTCCCCACGCGTCCCATTTCATCGGTGGAAGGAGTTCCTCGCGGTGAGT
CACGCGTTACAGTATTACAC

Downstream 100 bases:

>100_bases
TGCCCCACTCGGCTGCACTCAACGCGGCGCGTCGCTCCGCCGACCTGACCGCACTGGCCGACGGTGGCGCACTCGACGTC
ATCGTGATAGGCGGCGGCAT

Product: putative transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIADVLREVPLDGDDR
EALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQST
IQSADIVDSILDSAALATELTHALNGYLC

Sequences:

>Translated_189_residues
MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIADVLREVPLDGDDR
EALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQST
IQSADIVDSILDSAALATELTHALNGYLC
>Mature_189_residues
MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIADVLREVPLDGDDR
EALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQST
IQSADIVDSILDSAALATELTHALNGYLC

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2250_MYCTU (Q10528)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   F70779
- RefSeq:   NP_216766.2
- RefSeq:   NP_336780.1
- ProteinModelPortal:   Q10528
- EnsemblBacteria:   EBMYCT00000002573
- EnsemblBacteria:   EBMYCT00000069587
- GeneID:   888018
- GeneID:   924115
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2310
- KEGG:   mtu:Rv2250c
- TIGR:   MT2310
- TubercuList:   Rv2250c
- GeneTree:   EBGT00050000014685
- HOGENOM:   HBG669676
- OMA:   MTLYRRW
- ProtClustDB:   CLSK881396
- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647
- Gene3D:   G3DSA:1.10.357.10
- PRINTS:   PR00455

Pfam domain/function: PF00440 TetR_N; SSF46689 Homeodomain_like; SSF48498 TetR_like_C

EC number: NA

Molecular weight: Translated: 20494; Mature: 20494

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01081 HTH_TETR_1; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMAS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
MLTSHIADVLREVPLDGDDREALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCH
QQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQSTIQSADIVDSILDSAALATEL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THALNGYLC
HHHHHCCCC
>Mature Secondary Structure
MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMAS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
MLTSHIADVLREVPLDGDDREALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCH
QQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQSTIQSADIVDSILDSAALATEL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THALNGYLC
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036