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The map label for this gene is accD6

Identifier: 121638129

GI number: 121638129

Start: 2499388

End: 2500809

Strand: Direct

Name: accD6

Synonym: BCG_2264

Alternate gene names: 121638129

Gene position: 2499388-2500809 (Clockwise)

Preceding gene: 121638128

Following gene: 121638130

Centisome position: 57.14

GC content: 67.79

Gene sequence:

>1422_bases
ATGACAATCATGGCCCCCGAGGCGGTTGGCGAGTCGCTCGACCCCCGCGATCCGCTGTTGCGGCTGAGCAACTTCTTCGA
CGACGGCAGCGTGGAATTGCTGCACGAGCGTGACCGCTCCGGAGTGCTGGCCGCGGCGGGCACCGTCAACGGTGTGCGCA
CCATCGCGTTCTGCACCGACGGCACCGTGATGGGCGGCGCCATGGGCGTCGAGGGGTGCACGCACATCGTCAACGCCTAC
GACACTGCCATCGAAGACCAGAGTCCCATCGTGGGCATCTGGCATTCGGGTGGTGCCCGGCTGGCTGAAGGTGTGCGGGC
GCTGCACGCGGTAGGCCAGGTGTTCGAAGCCATGATCCGCGCGTCCGGCTACATCCCGCAGATCTCGGTGGTCGTCGGTT
TCGCCGCCGGCGGCGCCGCCTACGGACCGGCGTTGACCGACGTCGTCGTCATGGCGCCGGAAAGCCGGGTGTTCGTCACC
GGGCCCGACGTGGTGCGCAGCGTCACCGGCGAGGACGTCGACATGGCCTCGCTCGGTGGGCCGGAGACCCACCACAAGAA
GTCCGGGGTGTGCCACATCGTCGCCGACGACGAACTCGACGCCTACGACCGTGGGCGCCGGTTGGTCGGATTGTTCTGCC
AGCAGGGGCATTTCGATCGCAGCAAGGCCGAGGCCGGTGACACCGACATCCACGCGCTGCTGCCGGAATCCTCGCGACGT
GCCTACGACGTGCGTCCGATCGTGACGGCGATCCTCGATGCGGACACACCGTTCGACGAGTTCCAGGCCAATTGGGCGCC
GTCGATGGTGGTCGGGCTGGGTCGGCTGTCGGGTCGCACGGTGGGTGTACTGGCCAACAACCCGCTACGCCTGGGCGGCT
GCCTGAACTCCGAAAGCGCAGAGAAGGCAGCGCGTTTCGTGCGGCTGTGCGACGCGTTCGGGATTCCGCTGGTGGTGGTG
GTCGATGTGCCGGGCTATCTGCCCGGTGTCGACCAGGAGTGGGGTGGCGTGGTGCGCCGTGGCGCCAAGTTGCTGCACGC
GTTCGGCGAGTGCACCGTTCCGCGGGTCACGCTGGTCACCCGAAAGACCTACGGCGGGGCATACATTGCGATGAACTCCC
GGTCGTTGAACGCGACCAAGGTGTTCGCCTGGCCGGACGCCGAGGTCGCGGTGATGGGCGCTAAGGCGGCCGTCGGCATC
CTGCACAAGAAGAAGTTGGCCGCCGCTCCGGAGCACGAACGCGAAGCGCTGCACGACCAGTTGGCCGCCGAGCATGAGCG
CATCGCCGGCGGGGTCGACAGTGCGCTGGACATCGGTGTGGTCGACGAGAAGATCGACCCGGCGCATACTCGCAGCAAGC
TCACCGAGGCGCTGGCGCAGGCTCCGGCACGGCGCGGCCGCCACAAGAACATCCCGCTGTAG

Upstream 100 bases:

>100_bases
CCGGTATGCGATCAATAACTCGTTCGGATTCGGCGGCCACAACGTGGCAATCGCCTTCGGACGGTACTAAACCCCAGCGT
TACGCGACAGGAGACCTGCG

Downstream 100 bases:

>100_bases
TTCTGACCGCGAGCCGCTCCTCGCATGCTCGAACGGTGCCTACCGACGCGCTAACAATTCTCGAGAAGGCCGGCGGGTTC
GCCACCACCGCGCAATTGCT

Product: Acetyl/propionyl-CoA carboxylase subunit beta accD6

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAY
DTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVV
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL

Sequences:

>Translated_473_residues
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAY
DTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVV
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
>Mature_472_residues
TIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYD
TAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTG
PDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRA
YDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVV
DVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGIL
HKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI119943100, Length=444, Percent_Identity=41.2162162162162, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI295821216, Length=426, Percent_Identity=41.7840375586854, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI11545863, Length=470, Percent_Identity=28.0851063829787, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788655, Length=169, Percent_Identity=27.2189349112426, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=445, Percent_Identity=40.6741573033708, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI25147362, Length=445, Percent_Identity=40.6741573033708, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17552936, Length=471, Percent_Identity=29.2993630573248, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=428, Percent_Identity=23.1308411214953, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586065, Length=507, Percent_Identity=29.3885601577909, Blast_Score=181, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCC6_MYCBO (P63408)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855920.1
- ProteinModelPortal:   P63408
- SMR:   P63408
- EnsemblBacteria:   EBMYCT00000015195
- GeneID:   1091411
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2271
- GeneTree:   EBGT00050000015716
- HOGENOM:   HBG461319
- OMA:   KSARFVR
- ProtClustDB:   CLSK872034
- BioCyc:   MBOV233413:MB2271-MONOMER
- BRENDA:   6.4.1.3
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762

Pfam domain/function: PF01039 Carboxyl_trans

EC number: =6.4.1.3

Molecular weight: Translated: 50137; Mature: 50005

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTD
CCEECCHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCHHHCEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
CCCCCCCCCEEEEEECCCCCHHHCCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESA
CEEHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
HHHHHHHHCCCCCCCEECCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTD
CEECCHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCHHHCEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
CCCCCCCCCEEEEEECCCCCHHHCCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESA
CEEHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
HHHHHHHHCCCCCCCEECCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972