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The map label for this gene is kasA

Identifier: 121638127

GI number: 121638127

Start: 2496760

End: 2498010

Strand: Direct

Name: kasA

Synonym: BCG_2262

Alternate gene names: 121638127

Gene position: 2496760-2498010 (Clockwise)

Preceding gene: 121638126

Following gene: 121638128

Centisome position: 57.08

GC content: 66.99

Gene sequence:

>1251_bases
GTGAGTCAGCCTTCCACTGCTAATGGCGGTTTCCCCAGCGTTGTGGTGACCGCCGTCACAGCGACGACGTCGATCTCGCC
GGACATCGAGAGCACGTGGAAGGGTCTGTTGGCCGGCGAGAGCGGCATCCACGCACTCGAAGACGAGTTCGTCACCAAGT
GGGATCTAGCGGTCAAGATCGGCGGTCACCTCAAGGATCCGGTCGACAGCCACATGGGCCGACTCGACATGCGACGCATG
TCGTACGTCCAGCGGATGGGCAAGTTGCTGGGCGGACAGCTATGGGAGTCCGCCGGCAGCCCGGAGGTCGATCCAGACCG
GTTCGCCGTTGTTGTCGGCACCGGTCTAGGTGGAGCCGAGAGGATTGTCGAGAGCTACGACCTGATGAATGCGGGCGGCC
CCCGGAAGGTGTCCCCGCTGGCCGTTCAGATGATCATGCCCAACGGTGCCGCGGCGGTGATCGGTCTGCAGCTTGGGGCC
CGCGCCGGGGTGATGACCCCGGTGTCGGCCTGTTCGTCGGGCTCGGAAGCGATCGCCCACGCGTGGCGTCAGATCGTGAT
GGGCGACGCCGACGTCGCCGTCTGCGGCGGTGTCGAAGGACCCATCGAGGCGCTGCCCATCGCGGCGTTCTCCATGATGC
GGGCCATGTCGACCCGCAACGACGAGCCTGAGCGGGCCTCCCGGCCGTTCGACAAGGACCGCGACGGCTTTGTGTTCGGC
GAGGCCGGTGCGCTGATGCTCATCGAGACGGAGGAGCACGCCAAAGCCCGTGGCGCCAAGCCGTTGGCCCGATTGCTGGG
TGCCGGTATCACCTCGGACGCCTTTCATATGGTGGCGCCCGCGGCCGATGGTGTTCGTGCCGGTAGGGCGATGACTCGCT
CGCTGGAGCTGGCCGGGTTGTCGCCGGCGGACATCGACCACGTCAACGCGCACGGCACGGCGACGCCTATCGGCGACGCC
GCGGAGGCCAACGCCATCCGCGTCGCCGGTTGTGATCAGGCCGCGGTGTACGCGCCGAAGTCTGCGCTGGGCCACTCGAT
CGGCGCGGTCGGTGCGCTCGAGTCGGTGCTCACGGTGCTGACGCTGCGCGACGGCGTCATCCCGCCGACCCTGAACTACG
AGACACCCGATCCCGAGATCGACCTTGACGTCGTCGCCGGCGAACCGCGCTATGGCGATTACCGCTACGCAGTCAACAAC
TCGTTCGGGTTCGGCGGCCACAATGTGGCGCTTGCCTTCGGGCGTTACTGA

Upstream 100 bases:

>100_bases
AAGAAAACCCGGAGGCGGCTCAGGCGTTGCGCGCGAAGATTGAGTCGGAGAACCCCGATGCCGTTGCCAACGTTCAGGCG
AGGCTTGAGGCCGAGTCCAA

Downstream 100 bases:

>100_bases
AGCACGACATCGCGGGTCGCGAGGCCCGAGGTGGGGGTCCCCCCGCTTGCGGGGGCGAGTCGGACCGATATGGAAGGAAC
GTTCGCAAGACCAATGACGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRM
SYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGA
RAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDA
AEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNN
SFGFGGHNVALAFGRY

Sequences:

>Translated_416_residues
MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRM
SYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGA
RAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDA
AEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNN
SFGFGGHNVALAFGRY
>Mature_415_residues
SQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMS
YVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGAR
AGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGE
AGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDAA
EANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNS
FGFGGHNVALAFGRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.7314148681055, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=43.1506849315069, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41872631, Length=257, Percent_Identity=28.7937743190661, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=42.0537897310513, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=33.9901477832512, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=32.8467153284672, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=38.1679389312977, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI212642053, Length=253, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=253, Percent_Identity=26.4822134387352, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=29.8642533936652, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24644341, Length=437, Percent_Identity=37.5286041189931, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI221330659, Length=256, Percent_Identity=28.125, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19920632, Length=256, Percent_Identity=28.125, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581345, Length=254, Percent_Identity=27.9527559055118, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FAB1_MYCBO (P63455)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855918.1
- ProteinModelPortal:   P63455
- SMR:   P63455
- EnsemblBacteria:   EBMYCT00000016404
- GeneID:   1091409
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2269
- GeneTree:   EBGT00050000015144
- HOGENOM:   HBG757733
- OMA:   LMNEGGP
- ProtClustDB:   PRK07314
- BioCyc:   MBOV233413:MB2269-MONOMER
- BRENDA:   2.3.1.41
- GO:   GO:0005737
- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR11712

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 43317; Mature: 43185

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: ACT_SITE 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
CCCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEEEEEEEEE
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHCCCHHHHHH
AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCC
SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
CCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEEEEEEEEE
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHCCCHHHHHH
AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCHHEECCCCCCHHHHHHHHHHHHCCCC
SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972