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The map label for this gene is gcvT [H]

Identifier: 121638092

GI number: 121638092

Start: 2454686

End: 2455825

Strand: Reverse

Name: gcvT [H]

Synonym: BCG_2227c

Alternate gene names: 121638092

Gene position: 2455825-2454686 (Counterclockwise)

Preceding gene: 121638095

Following gene: 121638091

Centisome position: 56.14

GC content: 66.84

Gene sequence:

>1140_bases
GTGTGCCAGCAGGGACGCCCATTAGGGTGGGACGCCGTGAGCGATGTGCCAGAGCTGATACACGGACCGCTGGAAGACCG
CCATCGCGAGCTGGGTGCGAGTTTCGCCGAGTTCGGCGGCTGGCTGATGCCGGTCTCGTATGCCGGAACCGTCAGCGAGC
ACAACGCCACCCGCACCGCCGTCGGCCTTTTCGACGTCAGCCACCTGGGCAAGGCACTGGTCCGTGGACCGGGTGCGGCG
CAGTTCGTCAACTCCGCGCTCACCAACGACCTGGGTCGTATCGGGCCCGGCAAGGCGCAATACACCTTGTGCTGCACCGA
ATCCGGCGGTGTGATCGACGACCTGATCGCCTACTACGTCAGCGACGACGAGATCTTTCTGGTGCCCAACGCCGCCAATA
CCGCCGCGGTGGTCGGCGCGCTACAAGCTGCCGCACCGGGCGGTCTGAGCATCACCAATCTGCATCGGTCCTACGCGGTG
CTGGCCGTACAGGGGCCGTGTTCGACCGACGTGCTCACCGCGTTGGGGCTGCCAACCGAGATGGACTACATGGGCTACGC
CGACGCTTCGTACTCGGGGGTGCCGGTGCGTGTCTGTCGCACCGGCTACACCGGTGAGCACGGTTACGAACTGCTGCCGC
CATGGGAGTCGGCGGGTGTGGTGTTCGACGCACTGTTGGCGGCGGTATCAGCCGCGGGCGGCGAGCCCGCCGGCCTCGGT
GCTCGCGACACACTGCGCACTGAAATGGGCTATCCGCTGCACGGGCACGAGCTTTCGCTGGACATCTCGCCGCTGCAGGC
CCGATGCGGCTGGGCGGTCGGCTGGCGGAAGGACGCCTTCTTTGGTCGTGCGGCGTTGTTGGCCGAGAAAGCGGCCGGGC
CGCGGCGGCTGCTGCGGGGGCTGCGCATGGTCGGTCGCGGTGTGCTGCGCCCCGGGCTGGCTGTGCTTGTCGGGGATGAG
ACGGTTGGGGTCACCACGTCGGGAACGTTTTCTCCCACGTTGCAGGTCGGCATCGGGCTGGCGCTGATCGACAGTGATGC
CGGCATCGAAGACGGCCAGCAAATCAATGTCGACGTCCGCGGCCGTGCTGTCGAATGTCAAGTGGTGTGTCCGCCGTTCG
TTGCCGTGAAAACGCGCTGA

Upstream 100 bases:

>100_bases
AGCTCATCCAGGTAGGTGAGCAAGCCGGCCCGCTCGCGTGGGTTGGCAATTCCGGCGGCCTCGAGGGCGTCGAAGTCCAA
GGAATCGTACACCTGCCTAA

Downstream 100 bases:

>100_bases
GTCACCACTTGGTGGCAGCGGAGTGGCCTCCGGGCCGTCAATAACCGTTCGCCCACGGATAGAATCGGCCCATGACCAGC
GGCTCCCTTCAATTCACGGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAA
QFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAV
LAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG
ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDE
TVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR

Sequences:

>Translated_379_residues
MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAA
QFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAV
LAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG
ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDE
TVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR
>Mature_379_residues
MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAA
QFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAV
LAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG
ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDE
TVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=365, Percent_Identity=29.3150684931507, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI257796258, Length=334, Percent_Identity=29.6407185628743, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI24797151, Length=382, Percent_Identity=26.7015706806283, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=26.8493150684932, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=27.7955271565495, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI197927446, Length=329, Percent_Identity=25.531914893617, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI21361378, Length=329, Percent_Identity=25.531914893617, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789272, Length=372, Percent_Identity=38.1720430107527, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=30.8108108108108, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994052, Length=372, Percent_Identity=26.0752688172043, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=372, Percent_Identity=26.0752688172043, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32563613, Length=391, Percent_Identity=21.7391304347826, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320222, Length=377, Percent_Identity=31.5649867374005, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI20129441, Length=370, Percent_Identity=30.8108108108108, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI20130091, Length=348, Percent_Identity=24.4252873563218, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39629; Mature: 39629

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTA
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCCCEEE
VGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYV
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHEE
SDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAVQGPCSTDVLTALGLPTE
CCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEEECCCCCHHHHHHHCCCCC
MDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRG
CHHHHHHHCCCCCCCCEEEEECCHHHHHCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHH
LRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVR
HHHHHHHHCCCCEEEEECCCEEEEEECCCCCCEEEECEEEEEEECCCCCCCCCEEEEEEC
GRAVECQVVCPPFVAVKTR
CCEEEEEEECCCEEEEECC
>Mature Secondary Structure
MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMPVSYAGTVSEHNATRTA
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCCCEEE
VGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYTLCCTESGGVIDDLIAYYV
EEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHEE
SDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAVLAVQGPCSTDVLTALGLPTE
CCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCEEEEEEECCCCCHHHHHHHCCCCC
MDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESAGVVFDALLAAVSAAGGEPAGLG
CCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWRKDAFFGRAALLAEKAAGPRRLLRG
CHHHHHHHCCCCCCCCEEEEECCHHHHHCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHH
LRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTLQVGIGLALIDSDAGIEDGQQINVDVR
HHHHHHHHCCCCEEEEECCCEEEEEECCCCCCEEEECEEEEEEECCCCCCCCCEEEEEEC
GRAVECQVVCPPFVAVKTR
CCEEEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]