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The map label for this gene is 121638061

Identifier: 121638061

GI number: 121638061

Start: 2421833

End: 2423116

Strand: Direct

Name: 121638061

Synonym: BCG_2196

Alternate gene names: NA

Gene position: 2421833-2423116 (Clockwise)

Preceding gene: 121638056

Following gene: 121638067

Centisome position: 55.36

GC content: 65.89

Gene sequence:

>1284_bases
ATGAGTGCATGGCGGGCGCCCGAGGTGGGCAGTCGACTCGGGCGGAGGGTGTTGTGGTGCCTGCTGTGGCTGCTGGCCGG
CGTGGCGTTGGGCTACGTGGCCTGGCGGTTGTTCGGCCACACGCCGTATCGCATCGATATCGACATCTATCAGATGGGCG
CTCGAGCTTGGCTGGACGGGCGTCCGCTGTATGGCGGTGGTGTGTTGTTCCACACACCCATCGGGCTGAACCTCCCGTTC
ACCTATCCTCCACTGGCGGCCGTCCTGTTCAGCCCATTCGCCTGGTTGCAGATGCCGGCTGCCAGCGTCGCGATCACGGT
GCTAACCCTGGTGCTGCTGATCGCGTCGACGGCGATCGTGCTGACCGGCCTCGACGCATGGCCAACCTCCCGACTGGTAC
CCGCGCCGGCTCGGTTACGCCGGTTGTGGTTGGCCGTGCTCATCGTGGCTCCGGCAACGATTTGGCTGGAGCCGATCAGC
TCGAACTTCGCTTTCGGTCAGATCAATGTGGTGCTGATGACCCTGGTGATCGTCGACTGCTTCCCACGCCGAACGCCATG
GCCACGCGGGCTGATGTTGGGGCTGGGGATAGCCCTCAAACTCACCCCCGCGGTGTTTCTCCTCTACTTCCTGCTACGTC
GGGACGGTCGGGCCGCGCTGACGGCGCTGGCGTCGTTCGCGGTCGCCACGCTGCTCGGTTTCGTCCTGGCGTGGCGCGAC
TCCTGGGAGTACTGGACGCATACCCTTCACCACACGGACCGGATCGGCGCTGCCGCCTTGAACACAGACCAGAACATCGC
GGGCGCACTCGCGCGGTTGACGATTGGCGATGACGAACGCTTCGCACTGTGGGTGGCCGGATCCCTGCTCGTGTTGGCAG
CGACCATATGGGCGATGCGGCGAGTGTTGCGGGCCGGCGAGCCGACCCTGGCTGTGATCTGCGTCGCCCTGTTCGGGTTG
GTAGTTTCGCCGGTCTCGTGGTCACACCATTGGGTGTGGATGCTGCCGGCCGTGCTGGTGATTGGGCTACTGGGTTGGCG
TCGCCGCAACGTCGCGTTGGCCATGCTCAGCCTGGCCGGGGTGGTGCTGATGAGGTGGACACCGATCGACCTGCTTCCCC
AACACCGGGAGACGACTGCGGTCTGGTGGCGTCAACTCGCGGGGATGTCCTACGTGTGGTGGGCGCTGGCGGTCATCGTC
GTTGCCGGACTCACCGTTACCGCCAGGATGACGCCGCAGCGCTCGCTTACGCGCGGACTGACCCCGGCGCCGACGGCCAG
CTGA

Upstream 100 bases:

>100_bases
GGAACACCTCCAAAAAGCTACGCCCACCTTGACTGCATATGCAGGCGCCGTACAGCGCCACCATGCGCGCCTACGCGAAA
CTACTAGGCTGTTCTGCGAC

Downstream 100 bases:

>100_bases
CTAGCCAGCGGCTGTCTCGGGGATTCGTGCGGCGTCCGTTGAATTGGGATTTGCACCGGCACCGCCCGCGTTGCGGCCGT
CTTTGACACTGGCGGCATAG

Product: putative integral membrane protein

Products: NA

Alternate protein names: Alpha-D-mannose-alpha-(1-2)-mannosyltransferase; Alpha-mannosyltransferase; Alpha-manT; PPM-dependent mannosyltransferase; Polyprenol-phosphate-mannose alpha-mannosyltransferase; PPM alpha-mannosyltransferase

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPF
TYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPIS
SNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRD
SWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGL
VVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIV
VAGLTVTARMTPQRSLTRGLTPAPTAS

Sequences:

>Translated_427_residues
MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPF
TYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPIS
SNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRD
SWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGL
VVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIV
VAGLTVTARMTPQRSLTRGLTPAPTAS
>Mature_426_residues
SAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFT
YPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISS
NFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRDS
WEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLV
VSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVV
AGLTVTARMTPQRSLTRGLTPAPTAS

Specific function: Responsible for the addition of alpha-(1-2) mannose branches to the linear mannan core on the biosynthetic pathway to mature Lipoarabinomannan (LAM)

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMG_MYCTU (O53515)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842579
- PIR:   G70936
- RefSeq:   NP_216697.1
- RefSeq:   NP_336708.1
- ProteinModelPortal:   O53515
- EnsemblBacteria:   EBMYCT00000001476
- EnsemblBacteria:   EBMYCT00000070561
- GeneID:   888269
- GeneID:   924222
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2236
- KEGG:   mtu:Rv2181
- TIGR:   MT2236
- TubercuList:   Rv2181
- GeneTree:   EBGT00050000017048
- HOGENOM:   HBG657542
- OMA:   VWAMRRV
- ProtClustDB:   CLSK791680
- GO:   GO:0009405
- InterPro:   IPR018584

Pfam domain/function: PF09594 DUF2029

EC number: NA

Molecular weight: Translated: 47144; Mature: 47012

Theoretical pI: Translated: 11.67; Mature: 11.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17125e48)-; HASH(0x16fc62a8)-; HASH(0x173e2fbc)-; HASH(0x173a5a88)-; HASH(0x13c67700)-; HASH(0x167175b4)-; HASH(0x1740932c)-; HASH(0x1713ab7c)-; HASH(0x16912758)-; HASH(0x12dc7378)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHEECCCHHCCCC
RPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIV
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNFAFGQINVVLMTLVIVDC
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
FPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
SWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMR
CHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHH
RVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAG
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGL
HHHHCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHEEECCCHHHHHCCC
TPAPTAS
CCCCCCH
>Mature Secondary Structure 
SAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHEECCCHHCCCC
RPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIV
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNFAFGQINVVLMTLVIVDC
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
FPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
SWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMR
CHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHH
RVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAG
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGL
HHHHCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHEEECCCHHHHHCCC
TPAPTAS
CCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036