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The map label for this gene is mraW [H]

Identifier: 121638047

GI number: 121638047

Start: 2408123

End: 2409313

Strand: Reverse

Name: mraW [H]

Synonym: BCG_2182c

Alternate gene names: 121638047

Gene position: 2409313-2408123 (Counterclockwise)

Preceding gene: 121638048

Following gene: 121638046

Centisome position: 55.08

GC content: 65.16

Gene sequence:

>1191_bases
GTGCAAACCCGTGCACCGTGGTCTCTGCCCGAAGCGACCCTGGCGTACTTCCCCAACGCCAGGTTCGTGTCTTCGGACAG
GGACCTCGGTGCAGGGGCGGCGCCTGGAATAGCCGCGTCCCGAAGTACGGCTTGCCAGACCTGGGGAGGTATCACGGTGG
CTGATCCAGGTTCGGGGCCAACCGGTTTCGGTCATGTGCCGGTATTGGCGCAACGTTGCTTCGAACTGCTTACCCCCGCA
CTAACCCGCTACTATCCAGACGGCTCGCAGGCGGTCCTTCTCGACGCGACCATCGGCGCGGGCGGGCATGCGGAGCGGTT
TTTGGAGGGATTGCCGGGTCTGCGCCTGATCGGGCTCGACCGTGACCCAACCGCTCTGGACGTCGCGCGGTCTCGGCTGG
TGCGATTCGCTGACCGACTTACCCTGGTGCACACCCGCTATGACTGTCTGGGCGCAGCGCTGGCTGAATCCGGTTATGCC
GCAGTGGGATCAGTCGACGGAATCCTGTTCGATCTCGGCGTCTCATCCATGCAGCTCGACCGCGCCGAGCGGGGCTTCGC
CTACGCCACGGACGCGCCATTGGACATGCGGATGGACCCGACGACGCCGTTGACCGCAGCTGACATTGTCAACACTTACG
ACGAGGCGGCACTAGCCGACATCCTGCGTCGCTACGGAGAGGAGCGGTTTGCTCGGCGCATCGCTGCCGGTATCGTCCGC
CGACGCGCAAAAACCCCGTTCACCTCGACCGCCGAACTGGTTGCCCTGCTGTACCAGGCGATTCCAGCTCCGGCCCGGCG
TGTCGGCGGGCATCCAGCCAAGCGAACATTCCAGGCGCTGCGCATCGCGGTCAACGATGAGCTGGAATCGCTGCGCACGG
CCGTTCCTGCCGCGCTGGATGCCCTCGCTATCGGTGGGCGCATCGCGGTGCTGGCCTACCAGTCGCTAGAGGACAGGATC
GTCAAACGGGTGTTCGCCGAGGCAGTCGCGTCGGCCACCCCTGCGGGACTTCCGGTCGAACTTCCCGGCCATGAGCCGCG
ATTCCGTTCGTTAACGCACGGCGCCGAACGAGCGAGTGTGGCTGAGATCGAACGCAATCCCCGCAGTACTCCAGTGCGGT
TGCGGGCCCTGCAACGAGTCGAGCACCGGGCGCAATCGCAGCAATGGGCAACCGAGAAGGGTGATTCATGA

Upstream 100 bases:

>100_bases
CTCGAGATCTGGGATGCGCAAGCCTGGCAGAACTACCAACAAATCCATGAAGAGAACTTCTCCGCGGCCAGCGATGAAGC
ACTCGGTGACATCTTCTGAG

Downstream 100 bases:

>100_bases
GGGCCAAGCGTGAGGCACCGAAAAGCCGCAGCAGCGATCGTCGCAGGAGAGCCGACAGTCCTGCCGCGGCGACGAGGCGA
ACGACTACGAACTCGGCGCC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPA
LTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYA
AVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRI
VKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS

Sequences:

>Translated_396_residues
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPA
LTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYA
AVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRI
VKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
>Mature_396_residues
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPA
LTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYA
AVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRI
VKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=272, Percent_Identity=41.1764705882353, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI165377202, Length=197, Percent_Identity=40.1015228426396, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786270, Length=304, Percent_Identity=43.75, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI62472493, Length=334, Percent_Identity=38.0239520958084, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28571637, Length=334, Percent_Identity=38.0239520958084, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 42530; Mature: 42530

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGP
CCCCCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCC
TGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEECC
RDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCCCHHHHH
RAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
HHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALD
HHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASV
HHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
AEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGP
CCCCCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCC
TGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEECC
RDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCCCHHHHH
RAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
HHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALD
HHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASV
HHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
AEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]