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The map label for this gene is uppP

Identifier: 121638018

GI number: 121638018

Start: 2376018

End: 2376848

Strand: Reverse

Name: uppP

Synonym: BCG_2153c

Alternate gene names: 121638018

Gene position: 2376848-2376018 (Counterclockwise)

Preceding gene: 121638019

Following gene: 121638017

Centisome position: 54.33

GC content: 63.18

Gene sequence:

>831_bases
ATGTCTTGGTGGCAAGTCATCGTGTTGGCCGCGGCCCAGGGTTTGACCGAGTTCCTGCCGGTGTCGTCCTCGGGACATCT
GGCGATCGTGTCGCGGATCTTCTTCAGCGGCGACGCCGGTGCCTCGTTCACCGCCGTGAGCCAGTTGGGCACCGAGGCCG
CCGTAGTGATCTACTTTGCGCGCGATATTGTGCGCATCCTGAGCGCTTGGTTGCACGGCCTGGTCGTGAAGGCACATCGA
AACACCGATTATCGGCTGGGCTGGTATGTCATCATCGGCACAATCCCGATCTGCATTCTGGGCCTGTTCTTCAAAGACGA
CATCCGGTCGGGCGTCCGCAACCTGTGGGTCGTGGTGACCGCGCTGGTGGTGTTTTCCGGGGTGATCGCACTCGCCGAAT
ACGTGGGGCGCCAGAGTCGTCACATTGAGCGGTTGACCTGGCGGGATGCCGTGGTGGTTGGTATTGCCCAAACCCTGGCG
CTGGTCCCCGGGGTATCCAGGTCCGGGTCGACCATCAGCGCTGGACTGTTTCTCGGACTCGACCGTGAACTGGCCGCCCG
ATTCGGATTCCTGCTGGCCATTCCAGCGGTGTTCGCCTCCGGGTTGTTCTCGTTGCCCGACGCATTCCACCCGGTAACCG
AGGGCATGAGCGCTACTGGCCCGCAGTTGCTGGTGGCCACCCTGATCGCGTTCGTCCTCGGTCTGACCGCGGTGGCCTGG
CTGCTGCGGTTTCTGGTGCGACACAACATGTACTGGTTCGTCGGCTACCGGGTGCTCGTCGGGACGGGCATGCTCGTGCT
GCTGGCTACCGGGACGGTAGCCGCGACATGA

Upstream 100 bases:

>100_bases
CGACTCGGTGGCATCCGCGGCGCCGGTGTCGCGTTAGGCGCATCCGTCTACCGGCCGCCGGTAACCGGGTACCGTCGTCG
TCGTGACCGCGGCTCCGGCG

Downstream 100 bases:

>100_bases
CCGTCATCTTGCTACGCCATGCCCGTTCCACCTCGAACACCGCGGGCGTGCTGGCCGGCCGGTCCGGCGTCGACCTCGAC
GAGAAGGGGCGCGAGCAGGC

Product: undecaprenyl pyrophosphate phosphatase

Products: NA

Alternate protein names: Bacitracin resistance protein; Undecaprenyl pyrophosphate phosphatase

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHR
NTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLA
LVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAW
LLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT

Sequences:

>Translated_276_residues
MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHR
NTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLA
LVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAW
LLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
>Mature_275_residues
SWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRN
TDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLAL
VPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAWL
LRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT

Specific function: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin

COG id: COG1968

COG function: function code V; Uncharacterized bacitracin resistance protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uppP family

Homologues:

Organism=Escherichia coli, GI1789437, Length=264, Percent_Identity=35.2272727272727, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPP_MYCTU (O06239)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   D70577
- RefSeq:   NP_216652.1
- RefSeq:   NP_336664.1
- EnsemblBacteria:   EBMYCT00000003935
- EnsemblBacteria:   EBMYCT00000072054
- GeneID:   887612
- GeneID:   924279
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2194
- KEGG:   mtu:Rv2136c
- TIGR:   MT2194
- TubercuList:   Rv2136c
- GeneTree:   EBGT00050000016010
- HOGENOM:   HBG391969
- OMA:   HSMYWFV
- ProtClustDB:   PRK00281
- BioCyc:   MetaCyc:MONOMER-15232
- BRENDA:   3.6.1.27
- GO:   GO:0016311
- HAMAP:   MF_01006
- InterPro:   IPR003824
- TIGRFAMs:   TIGR00753

Pfam domain/function: PF02673 BacA

EC number: =3.6.1.27

Molecular weight: Translated: 29733; Mature: 29602

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12386f6c)-; HASH(0x15dbedc0)-; HASH(0x12a534b8)-; HASH(0x168f953c)-; HASH(0x125cdbd0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCHHHHHHHHHHHCCHHEEHCCCCCCCH
>Mature Secondary Structure 
SWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFA
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHH
RDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVT
HHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHCCC
DRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAW
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
HHHHHHHCCCHHHHHHHHHHHCCHHEEHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036