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The map label for this gene is sigC

Identifier: 121637954

GI number: 121637954

Start: 2310596

End: 2311153

Strand: Direct

Name: sigC

Synonym: BCG_2088

Alternate gene names: 121637954

Gene position: 2310596-2311153 (Clockwise)

Preceding gene: 121637951

Following gene: 121637963

Centisome position: 52.82

GC content: 67.74

Gene sequence:

>558_bases
ATGACCGCGACGGCAAGCGACGACGAGGCCGTTACCGCACTCGCCTTGTCGGCGGCCAAGGGGAACGGGCGGGCCCTTGA
GGCGTTTATCAAAGCCACCCAGCAAGACGTGTGGCGGTTCGTCGCCTATCTGTCCGACGTGGGCAGTGCGGACGATCTCA
CCCAAGAGACATTCCTACGAGCGATCGGCGCCATCCCGCGGTTTTCCGCACGCTCCAGCGCCCGAACTTGGTTGCTGGCC
ATCGCGCGCCATGTCGTCGCCGATCACATCCGCCACGTCCGATCCCGGCCCCGCACCACCCGCGGCGCGCGTCCCGAACA
TCTCATAGACGGCGACCGCCATGCCCGCGGATTCGAAGACCTCGTCGAGGTAACCACGATGATCGCCGACCTAACCACCG
ACCAACGGGAAGCGCTGCTGCTGACCCAGCTGCTCGGGCTGTCCTATGCGGACGCCGCGGCGGTGTGCGGCTGCCCGGTG
GGCACCATCCGATCCCGTGTCGCTCGAGCGCGCGATGCGCTGCTTGCCGACGCGGAGCCCGACGACCTCACCGGCTAG

Upstream 100 bases:

>100_bases
CAAAGCGCATTCGACGCCGCGCTCCCCCGGCTGCTCGGCGGCGGGATCTACGACGACCGGTCGTAGACTGACCGGACCTG
CCGGGCTATGGTTTATGCCC

Downstream 100 bases:

>100_bases
GCAGACCGGCCACCCACATGGCGGCCCGGTGGACAGAATCGACCGCCGCTACCCCAGCCGGCAGCAGCGGGCGCGCTATC
ATGACCACCGAAATACCCAG

Product: RNA polymerase sigma factor SigC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLA
IARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPV
GTIRSRVARARDALLADAEPDDLTG

Sequences:

>Translated_185_residues
MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLA
IARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPV
GTIRSRVARARDALLADAEPDDLTG
>Mature_184_residues
TATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAI
ARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVG
TIRSRVARARDALLADAEPDDLTG

Specific function: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released

COG id: COG1595

COG function: function code K; DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sigma-70 factor family. ECF subfamily

Homologues:

Organism=Escherichia coli, GI1788926, Length=179, Percent_Identity=29.608938547486, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: <10 [C]

Swissprot (AC and ID): RPSC_MYCBO (P66810)

Other databases:

- EMBL:   BX248341
- RefSeq:   NP_855745.1
- ProteinModelPortal:   P66810
- EnsemblBacteria:   EBMYCT00000014349
- GeneID:   1091097
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2095
- GeneTree:   EBGT00050000015257
- HOGENOM:   HBG753452
- OMA:   NERDDLT
- ProtClustDB:   PRK09649
- BioCyc:   MBOV233413:MB2095-MONOMER
- InterPro:   IPR014284
- InterPro:   IPR000838
- InterPro:   IPR007627
- InterPro:   IPR013249
- InterPro:   IPR013325
- InterPro:   IPR013324
- TIGRFAMs:   TIGR02937

Pfam domain/function: PF04542 Sigma70_r2; PF08281 Sigma70_r4_2; SSF88946 Sigma_r2; SSF88659 Sigma_r3_r4

EC number: NA

Molecular weight: Translated: 19966; Mature: 19834

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01063 SIGMA70_ECF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLR
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFED
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHCCHHHH
LVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTIRSRVARARDALLADAEP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DDLTG
CCCCC
>Mature Secondary Structure 
TATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLR
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFED
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHCCHHHH
LVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTIRSRVARARDALLADAEP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
DDLTG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972