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The map label for this gene is erg3

Identifier: 121637716

GI number: 121637716

Start: 2057523

End: 2058425

Strand: Direct

Name: erg3

Synonym: BCG_1848

Alternate gene names: 121637716

Gene position: 2057523-2058425 (Clockwise)

Preceding gene: 121637713

Following gene: 121637717

Centisome position: 47.03

GC content: 61.24

Gene sequence:

>903_bases
ATGCGGGACCCGGTACTGTTCGCCATTCCATGTTTTCTATTGCTGCTGATTCTCGAATGGACGGCGGCCCGCAAGCTGGA
AAGCATCGAGACCGCTGCTACCGGGCAGCCACGGCCCGCCTCGGGCGCTTACCTCACCCGCGACTCGGTGGCCAGCATCT
CGATGGGGCTGGTTTCGATAGCCACCACCGCCGGCTGGAAGTCCCTTGCCCTGCTCGGTTATGCCGCAATCTATGCCTAC
CTTGCCCCCTGGCAGCTGTCCGCCCACCGGTGGTACACCTGGGTAATCGCGATCGTTGGTGTCGATCTGCTGTACTACTC
CTATCACCGCATCGCCCACCGAGTTCGGCTGATCTGGGCTACCCACCAGGCGCATCACTCCAGCGAATACTTCAACTTCG
CCACCGCGCTGCGCCAGAAGTGGAACAACAGCGGCGAGATTCTCATGTGGGTTCCGCTGCCACTGATGGGGCTTCCCCCT
TGGATGGTGTTCTGCAGTTGGTCGCTGAACTTGATCTACCAGTTCTGGGTGCACACCGAGCGGATCGACAGGCTGCCGCG
GTGGTTCGAATTCGTCTTCAATACCCCGTCGCACCACCGGGTCCACCACGGAATGGACCCGGTGTATCTGGACAAGAACT
ATGGCGGCATCCTCATCATCTGGGACCGCCTGTTCGGTAGCTTTCAGCCGGAGCTATTCCGACCGCATTATGGCCTGACC
AAGCGGGTCGACACGTTCAACATCTGGAAGCTGCAGACCCGCGAGTACGTGGCGATCGTGCGTGACTGGCGGTCGGCAAC
ACGTCTGCGGGATCGGCTGGGCTACGTCTTCGGACCGCCGGGCTGGGAACCGCGCACCATCGATAAATCCAATGCCGCCG
CCTCCCTGGTCACGTCTCGGTAA

Upstream 100 bases:

>100_bases
AAGCGGCTTCACTGTCAAGTCGTCACCTGTCACGCATGCGAGTCGTAGCCTGTCTGATGTGGATGCCGTCGCCGGATTCT
TCTCAGCGCTGCCCGAGGAA

Downstream 100 bases:

>100_bases
CGTCGCGACCCGACATTGCGAAAGTATTACCGTCGGGTTTTGGTACGCCTTAGCCGTAACCGGCGGCGGGCGATGCGCTT
GGCCCCGACGGATGGGAGTT

Product: membrane-bound C-5 sterol desaturase erg3

Products: NA

Alternate protein names: Sterol-C5-desaturase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAY
LAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPP
WMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLT
KRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR

Sequences:

>Translated_300_residues
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAY
LAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPP
WMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLT
KRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
>Mature_300_residues
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAY
LAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPP
WMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLT
KRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family

Homologues:

Organism=Homo sapiens, GI51972212, Length=283, Percent_Identity=37.8091872791519, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25144659, Length=249, Percent_Identity=33.7349397590361, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERG3_MYCBO (P68434)

Other databases:

- EMBL:   AF283500
- EMBL:   BX248340
- RefSeq:   NP_855496.1
- EnsemblBacteria:   EBMYCT00000017593
- GeneID:   1092941
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1844
- GeneTree:   EBGT00050000017401
- HOGENOM:   HBG742665
- OMA:   WIHTERI
- ProtClustDB:   CLSK791408
- BioCyc:   MBOV233413:MB1844-MONOMER
- InterPro:   IPR006694

Pfam domain/function: PF04116 FA_hydroxylase

EC number: NA

Molecular weight: Translated: 34883; Mature: 34883

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1634236c)-; HASH(0x165cd604)-; HASH(0x12765ea0)-; HASH(0x124304ec)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHH
ATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWA
HHHCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
THQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTE
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLT
HHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCC
KRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
CCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHCCH
>Mature Secondary Structure
MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHH
ATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWA
HHHCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
THQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTE
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSFQPELFRPHYGLT
HHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCC
KRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
CCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972