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The map label for this gene is eccA5

Identifier: 121637699

GI number: 121637699

Start: 2037702

End: 2039534

Strand: Direct

Name: eccA5

Synonym: BCG_1830

Alternate gene names: 121637699

Gene position: 2037702-2039534 (Clockwise)

Preceding gene: 121637698

Following gene: 121637700

Centisome position: 46.58

GC content: 63.45

Gene sequence:

>1833_bases
ATGACACGCCCGCAGGCCGCCGCCGAAGATGCCCGCAACGCCATGGTCGCCGGTCTGCTGGCATCGGGGATCTCCGTCAA
TGGACTGCAGCCCAGCCATAACCCGCAGGTGGCCGCCCAAATGTTCACCACGGCGACCAGGCTGGATCCCAAGATGTGTG
ATGCCTGGCTGGCTCGGCTGCTGGCCGGCGACCAGAGCATCGAAGTGCTCGCCGGCGCATGGGCTGCGGTGCGGACTTTC
GGCTGGGAAACCCGCCGCCTCGGCGTGACGGATCTGCAGTTCCGCCCCGAGGTGTCCGACGGGCTATTCCTGCGACTGGC
GATTACCAGCGTAGATTCGCTGGCCTGCGCTTACGCGGCGGTCCTCGCCGAGGCCAAGCGTTACCAGGAGGCGGCAGAGC
TGCTCGACGCCACCGATCCTCGCCATCCGTTCGACGCCGAGCTGGTGAGTTACGTGCGGGGCGTGCTGTACTTCCGCACC
AAACGCTGGCCTGACGTTCTTGCGCAGTTCCCCGAGGCAACGCAGTGGCGTCACCCCGAGCTAAAGGCCGCGGGGGCGGC
GATGGCCACCACGGCGCTGGCGTCGCTCGGGGTGTTCGAAGAGGCCTTTCGGCGCGCTCAGGAAGCAATCGAAGGTGACC
GGGTGCCGGGCGCGGCTAACATCGCCTTGTACACCCAAGGCATGTGCCTGCGGCACGTCGGCCGTGAGGAGGAAGCTGTC
GAACTCCTGCGCCGCGTGTATTCGCGCGATGCGAAGTTCACCCCGGCCCGCGAGGCGCTGGATAACCCCAACTTTCGGCT
GATCCTCACCGACCCGGAAACGATTGAGGCGCGCACAGATCCGTGGGATCCGGACAGTGCGCCAACCCGCGCTCAGACCG
AGGCCGCCCGCCATGCCGAGATGGCCGCGAAGTACTTGGCCGAAGGGGATGCCGAGCTCAACGCGATGCTTGGCATGGAG
CAGGCCAAGAAGGAGATCAAGCTCATCAAGTCGACGACGAAGGTGAATTTAGCGCGTGCCAAGATGGGGCTTCCGGTCCC
GGTTACGTCGCGCCACACCTTGTTGCTCGGGCCGCCCGGTACCGGGAAGACTTCGGTCGCAAGGGCTTTCACCAAGCAGC
TGTGCGGGTTGACAGTGCTGCGCAAGCCGCTGGTGGTGGAGACCAGCCGCACCAAGCTGTTGGGCCGGTACATGGCCGAC
GCCGAGAAGAACACCGAGGAGATGCTCGAAGGGGCGTTGGGCGGTGCGGTCTTCTTTGACGAGATGCACACTCTGCATGA
GAAGGGCTACTCCCAGGGCGACCCGTACGGTAACGCGATCATCAACACGCTGCTGTTGTACATGGAAAATCACCGTGACG
AGCTGGTGGTGTTTGGTGCGGGTTACGCCAAAGCGATGGAGAAAATGCTCGAGGTGAATCAGGGTCTGCGCCGGCGCTTT
TCGACGGTGATCGAGTTCTTCAGCTACACCCCGCAGGAGCTGATCGCACTGACCCAGCTGATGGGTCGGGAGAACGAAGA
CGTGATCACTGAGGAAGAGTCTCAAGTGTTGTTGCCGTCGTATACCAAGTTCTACATGGAGCAGAGCTACTCCGAGGACG
GCGACCTGATCCGCGGGATCGATCTGTTGGGCAATGCCGGCTTTGTGCGCAACGTGGTGGAGAAGGCCCGCGACCACCGT
AGTTTCCGTTTGGACGATGAGGATCTCGACGCCGTACTGGCCAGCGATCTCACCGAATTCAGCGAGGATCAGCTGCGCCG
ATTCAAGGAGTTGACTCGCGAGGACCTGGCCGAAGGGCTGCGCGCTGCGGTCGCGGAGAAGAAGACGAAGTAG

Upstream 100 bases:

>100_bases
CACTCCTGGTCATCCCCAGTCGGAACCTGCGTGACCACGACGAGCTCGTGCTGCCGGTGGGCCAGGAACTCGAGCACGCG
ACAAGCTCGTTTGTGGGGCA

Downstream 100 bases:

>100_bases
GCACTCTTTTCGTCGGTGTCACTGGCTACTTTGACCTGAACAGTCGGCGGTGGGTGAGTGGTCTGTGGTTGGCGAATGAG
GCGGGGCGGGGCGGAGACTG

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component A5; Type VII secretion system protein EccA5; T7SS protein EccA5

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTF
GWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRT
KRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAV
ELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGME
QAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMAD
AEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRF
STVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHR
SFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK

Sequences:

>Translated_610_residues
MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTF
GWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRT
KRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAV
ELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGME
QAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMAD
AEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRF
STVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHR
SFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK
>Mature_609_residues
TRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFG
WETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTK
RWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVE
LLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQ
AKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADA
EKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFS
TVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRS
FRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK

Specific function: Shows ATPase activity. Could provide energy for export of ESX-5 substrates

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cbxX/cfxQ family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCA5_MYCTU (P63744)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   G70930
- RefSeq:   NP_216314.1
- RefSeq:   NP_336304.1
- ProteinModelPortal:   P63744
- SMR:   P63744
- EnsemblBacteria:   EBMYCT00000000152
- EnsemblBacteria:   EBMYCT00000069757
- GeneID:   885543
- GeneID:   925100
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1847
- KEGG:   mtu:Rv1798
- TIGR:   MT1847
- TubercuList:   Rv1798
- GeneTree:   EBGT00050000015038
- HOGENOM:   HBG569278
- OMA:   TEFSERQ
- ProtClustDB:   CLSK791401
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR000641
- InterPro:   IPR011990
- Gene3D:   G3DSA:1.25.40.10
- PRINTS:   PR00819
- SMART:   SM00382

Pfam domain/function: PF00004 AAA

EC number: NA

Molecular weight: Translated: 67757; Mature: 67626

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAA
HCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
VLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC
LKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHCCCCHHHH
ELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAE
HHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
MAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
TGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFD
CCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHH
EMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
STVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGI
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCHHHHH
DLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGL
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAVAEKKTK
HHHHHHHCCC
>Mature Secondary Structure 
TRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
LAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAA
HCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
VLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPE
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC
LKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHCCCCHHHH
ELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAE
HHHHHHHHCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
MAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
TGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFD
CCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHH
EMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
STVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGI
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCHHHHH
DLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGL
HHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAVAEKKTK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036