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The map label for this gene is xerD

Identifier: 121637608

GI number: 121637608

Start: 1931420

End: 1932355

Strand: Direct

Name: xerD

Synonym: BCG_1739

Alternate gene names: 121637608

Gene position: 1931420-1932355 (Clockwise)

Preceding gene: 121637607

Following gene: 121637615

Centisome position: 44.15

GC content: 67.2

Gene sequence:

>936_bases
ATGAAGACGCTGGCACTGCAATTGCAGGGCTACCTCGACCATCTGACGATCGAACGAGGTGTCGCGGCAAACACATTGAG
CTCCTACCGACGTGATCTGCGCCGCTACTCCAAGCACCTGGAAGAACGAGGGATTACCGATCTGGCCAAGGTCGGCGAGC
ACGACGTCAGCGAGTTCCTGGTGGCATTGCGGCGCGGGGATCCTGATTCCGGCACGGCGGCGTTGTCCGCGGTGTCGGCG
GCACGGGCGCTGATCGCGGTGCGCGGGCTGCATCGCTTCGCTGCCGCAGAAGGGCTGGCCGAACTGGACGTGGCGCGCGC
CGTCCGGCCACCGACGCCGAGCCGGCGATTGCCTAAGAGCCTGACAATCGACGAGGTGCTATCGCTGCTCGAAGGTGCGG
GCGGCGATAAACCGTCCGACGGCCCGCTGACGCTGCGAAACCGTGCGGTGCTGGAACTGCTGTACTCGACCGGGGCGCGG
ATCTCCGAGGCCGTCGGCCTTGACCTCGACGACATCGACACCCACGCCAGATCGGTGTTGTTGCGCGGCAAGGGTGGTAA
GCAGCGGCTGGTTCCGGTGGGACGCCCGGCAGTGCACGCGCTGGACGCCTATCTGGTGCGGGGACGGCCCGACTTAGCGC
GGCGGGGCCGCGGAACGGCGGCGATCTTTCTCAACGCGCGCGGCGGCCGGTTGTCACGGCAAAGCGCGTGGCAGGTTCTG
CAGGACGCGGCCGAGCGTGCCGGCATCACCGCCGGTGTTTCGCCGCATATGTTGAGGCATTCGTTCGCCACGCATCTGCT
GGAGGGTGGCGCCGATGTCCGGGTGGTGCAGGAATTGCTGGGGCACGCCTCGGTGACCACGACGCAGATCTATACCCTGG
TCACCGTCCATGCACTGCGCGAGGTGTGGGCGGGAGCTCACCCGCGGGCACGCTAA

Upstream 100 bases:

>100_bases
TGGCCGTGCACGCGGTGACGACCGGGTTCGCCCAGCCACGCCCACTCGATACCGAATGGATCGACAGGCCAACGGCGTTC
GCCGCGCGGAGAGCCGAGCG

Downstream 100 bases:

>100_bases
GCGATGACCGTCACTAGCGGTAGCGGTTGCTGGTCACTTGGCTCGCCCGCGACACAGAGGTTGCGCCTCTCGCTCATGGA
TCGTCTTCGTCGCTGTCGTG

Product: site-specific tyrosine recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGITDLAKVGEHDVSEFLVALRRGDPDSGTAALSAVSA
ARALIAVRGLHRFAAAEGLAELDVARAVRPPTPSRRLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGAR
ISEAVGLDLDDIDTHARSVLLRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAIFLNARGGRLSRQSAWQVL
QDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGHASVTTTQIYTLVTVHALREVWAGAHPRAR

Sequences:

>Translated_311_residues
MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGITDLAKVGEHDVSEFLVALRRGDPDSGTAALSAVSA
ARALIAVRGLHRFAAAEGLAELDVARAVRPPTPSRRLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGAR
ISEAVGLDLDDIDTHARSVLLRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAIFLNARGGRLSRQSAWQVL
QDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGHASVTTTQIYTLVTVHALREVWAGAHPRAR
>Mature_311_residues
MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGITDLAKVGEHDVSEFLVALRRGDPDSGTAALSAVSA
ARALIAVRGLHRFAAAEGLAELDVARAVRPPTPSRRLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGAR
ISEAVGLDLDDIDTHARSVLLRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAIFLNARGGRLSRQSAWQVL
QDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGHASVTTTQIYTLVTVHALREVWAGAHPRAR

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=311, Percent_Identity=41.8006430868167, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI1790244, Length=311, Percent_Identity=36.0128617363344, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790767, Length=193, Percent_Identity=32.1243523316062, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790768, Length=175, Percent_Identity=33.7142857142857, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_MYCBO (P67637)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855380.1
- ProteinModelPortal:   P67637
- SMR:   P67637
- EnsemblBacteria:   EBMYCT00000016720
- GeneID:   1092677
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1727
- GeneTree:   EBGT00050000015380
- HOGENOM:   HBG727654
- OMA:   DTQARSV
- ProtClustDB:   PRK00283
- BioCyc:   MBOV233413:MB1727-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33518; Mature: 33518

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: NA

Important sites: ACT_SITE 160-160 ACT_SITE 184-184 ACT_SITE 256-256 ACT_SITE 259-259 ACT_SITE 282-282 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGITDLAKVGEHDVSEFL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHH
VALRRGDPDSGTAALSAVSAARALIAVRGLHRFAAAEGLAELDVARAVRPPTPSRRLPKS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
LTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGARISEAVGLDLDDIDTHARSVL
CCHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHEE
LRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAIFLNARGGRLSRQSAWQVL
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
QDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGHASVTTTQIYTLVTVHALR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EVWAGAHPRAR
HHHCCCCCCCC
>Mature Secondary Structure
MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERGITDLAKVGEHDVSEFL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHH
VALRRGDPDSGTAALSAVSAARALIAVRGLHRFAAAEGLAELDVARAVRPPTPSRRLPKS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
LTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGARISEAVGLDLDDIDTHARSVL
CCHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHEE
LRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRGTAAIFLNARGGRLSRQSAWQVL
EECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHH
QDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVVQELLGHASVTTTQIYTLVTVHALR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EVWAGAHPRAR
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972