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The map label for this gene is argD

Identifier: 121637563

GI number: 121637563

Start: 1873990

End: 1875192

Strand: Direct

Name: argD

Synonym: BCG_1694

Alternate gene names: 121637563

Gene position: 1873990-1875192 (Clockwise)

Preceding gene: 121637562

Following gene: 121637564

Centisome position: 42.84

GC content: 71.82

Gene sequence:

>1203_bases
ATGACCGGCGCTTCGACCACGACGGCGACCATGCGGCAGCGGTGGCAAGCCGTGATGATGAACAACTACGGCACCCCCCC
GATAGCGCTGGCCAGCGGTGACGGCGCCGTGGTCACCGACGTGGACGGCAGAACCTATATCGACCTGCTCGGCGGCATCG
CGGTCAACGTGCTGGGCCATCGCCACCCCGCGGTCATCGAGGCCGTCACCCGGCAGATGTCGACGCTGGGGCACACCTCC
AACCTGTATGCCACCGAACCGGGCATCGCGCTGGCCGAGGAGCTGGTCGCGCTGCTGGGGGCCGACCAGCGGACGCGAGT
GTTCTTCTGCAACTCCGGCGCCGAGGCCAACGAGGCGGCGTTCAAGCTGTCTCGGCTCACCGGACGCACGAAACTGGTCG
CCGCCCACGACGCCTTCCACGGCCGCACCATGGGCTCGCTGGCGCTCACCGGACAACCGGCCAAGCAAACGCCGTTCGCG
CCGCTGCCCGGCGACGTCACGCACGTCGGCTACGGCGACGTCGACGCGTTGGCCGCCGCCGTCGATGACCACACCGCCGC
GGTGTTCCTGGAACCGATCATGGGGGAGAGCGGGGTCGTCGTCCCGCCCGCGGGCTACCTTGCCGCCGCCCGCGACATCA
CGGCGCGGCGCGGCGCGCTGCTGGTGCTCGACGAGGTGCAAACCGGGATGGGCCGCACCGGAGCGTTCTTCGCCCACCAG
CACGACGGCATCACCCCGGACGTGGTGACCCTGGCCAAGGGTCTGGGCGGCGGGCTGCCGATCGGTGCCTGCCTGGCCGT
CGGGCCGGCCGCCGAACTACTGACCCCAGGCCTGCACGGCAGCACCTTCGGCGGCAACCCGGTCTGCGCCGCGGCGGCGC
TGGCGGTGCTACGGGTGCTGGCGAGCGACGGCCTGGTCCGCCGCGCCGAAGTCTTGGGCAAATCGTTGCGGCACGGCATC
GAAGCGCTCGGCCACCCGCTCATCGACCACGTGCGCGGACGCGGACTGCTGTTGGGCATCGCGCTGACCGCCCCGCACGC
CAAGGACGCCGAGGCCACCGCCCGCGACGCCGGTTACCTGGTCAACGCGGCCGCACCCGACGTCATCCGGTTGGCGCCGC
CGCTGATCATCGCCGAAGCACAGCTCGACGGCTTTGTCGCCGCCTTGCCGGCAATCCTGGACCGCGCCGTGGGGGCCCCG
TGA

Upstream 100 bases:

>100_bases
GCGGGGTGCCCAGCGCGCACATCATCGATGGGCGGGTCACACACTGCGTGTTGGTGGAGTTGTTCACCGACGCGGGCACC
GGCACCAAGGTGGTGCGCGG

Downstream 100 bases:

>100_bases
TCAGGCATTTCCTGCGCGACGACGATCTGTCCCCGGCCGAACAGGCCGAGGTGCTCGAGCTCGCGGCCGAGCTGAAGAAA
GACCCGGTTAGCCGTCGTCC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTS
NLYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFA
PLPGDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQ
HDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGI
EALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP

Sequences:

>Translated_400_residues
MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTS
NLYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFA
PLPGDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQ
HDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGI
EALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP
>Mature_399_residues
TGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTSN
LYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAP
LPGDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQH
DGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGIE
ALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=35.6410256410256, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI284507298, Length=286, Percent_Identity=38.8111888111888, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=29.2906178489703, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI24119277, Length=411, Percent_Identity=30.9002433090024, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=28.0871670702179, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226442709, Length=378, Percent_Identity=28.8359788359788, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=27.1186440677966, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=42.2885572139304, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1789759, Length=419, Percent_Identity=39.3794749403341, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=38.2051282051282, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787560, Length=402, Percent_Identity=34.3283582089552, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1786349, Length=352, Percent_Identity=32.9545454545455, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=28.537170263789, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=33.5038363171356, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI32564660, Length=414, Percent_Identity=29.951690821256, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=255, Percent_Identity=35.2941176470588, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=28.9099526066351, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17541228, Length=419, Percent_Identity=24.3436754176611, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71981843, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=33.9950372208437, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=33.7264150943396, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6321456, Length=419, Percent_Identity=25.5369928400955, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=312, Percent_Identity=25, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357415, Length=374, Percent_Identity=34.7593582887701, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI28574759, Length=406, Percent_Identity=31.2807881773399, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161085790, Length=413, Percent_Identity=30.9927360774818, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356575, Length=443, Percent_Identity=30.0225733634311, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281366494, Length=428, Percent_Identity=26.1682242990654, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667139, Length=428, Percent_Identity=26.1682242990654, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667143, Length=428, Percent_Identity=26.1682242990654, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_MYCBO (P63569)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855335.1
- ProteinModelPortal:   P63569
- SMR:   P63569
- EnsemblBacteria:   EBMYCT00000016949
- GeneID:   1092626
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1683
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   MDNYGTP
- ProtClustDB:   PRK03244
- BioCyc:   MBOV233413:MB1683-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 40910; Mature: 40779

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 139-139 BINDING 142-142 BINDING 281-281 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGH
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCC
RHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAA
CCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
FKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAPLPGDVTHVGYGDVDALAAA
HHHHHHCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQ
HCCCCEEEEEEHHCCCCCEEECCCHHHHHHHHHHHCCCEEEEEECHHCCCCCCCEEEEEC
HDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVL
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYL
HCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEEEECCCCCCCHHHHHCCCEE
VNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP
EECCCCCHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGH
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCC
RHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAA
CCHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
FKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAPLPGDVTHVGYGDVDALAAA
HHHHHHCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
VDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQ
HCCCCEEEEEEHHCCCCCEEECCCHHHHHHHHHHHCCCEEEEEECHHCCCCCCCEEEEEC
HDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVL
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYL
HCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEEEECCCCCCCHHHHHCCCEE
VNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP
EECCCCCHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972