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The map label for this gene is ilvA

Identifier: 121637480

GI number: 121637480

Start: 1777923

End: 1779212

Strand: Direct

Name: ilvA

Synonym: BCG_1611

Alternate gene names: 121637480

Gene position: 1777923-1779212 (Clockwise)

Preceding gene: 121637479

Following gene: 121637481

Centisome position: 40.64

GC content: 66.59

Gene sequence:

>1290_bases
GTGTCCGCCGAACTGAGCCAGAGCCCGAGCAGCTCGCCGCTGTTTTCACTATCTGGGGCAGACATCGACCGTGCCGCCAA
GCGGATCGCACCGGTAGTCACGCCCACCCCGTTGCAACCTAGCGATCGGTTGTCGGCGATCACTGGCGCCACGGTCTACC
TCAAGCGCGAAGACTTGCAGACGGTGCGCTCTTATAAGCTACGCGGAGCGTACAACCTGTTGGTGCAGTTGTCCGATGAG
GAACTGGCCGCGGGCGTGGTGTGTTCTTCTGCGGGCAACCACGCGCAGGGCTTCGCGTATGCGTGTCGCTGTCTGGGTGT
GCACGGCCGGGTCTACGTACCTGCCAAAACCCCCAAGCAGAAGCGTGACCGGATCCGCTACCACGGCGGGGAGTTCATCG
ACCTGATCGTGGGTGGGTCGACCTATGATCTGGCTGCGGCGGCGGCCCTTGAGGACGTGGAACGCACCGGGGCCACGCTG
GTACCGCCGTTTGACGACCTGCGCACCATCGCCGGCCAGGGCACGATAGCCGTCGAAGTGCTTGGCCAGCTCGAGGACGA
GCCGGACCTGGTGGTGGTCCCGGTGGGTGGCGGCGGCTGCATCGCGGGGATCACCACCTACCTGGCCGAGCGGACGACCA
ACACCGCGGTGCTGGGCGTCGAGCCGGCTGGTGCGGCCGCCATGATGGCCGCGCTCGCGGCGGGCGAGCCGGTGACGCTG
GACCATGTCGACCAGTTCGTCGACGGCGCCGCGGTGAACCGGGCGGGCACGCTGACCTATGCCGCGCTAGCCGCCGCCGG
CGACATGGTTTCGCTCACCACCGTCGACGAGGGTGCGGTGTGCACGGCGATGCTCGATCTGTATCAGAACGAGGGCATCA
TCGCCGAACCGGCCGGTGCCCTGTCGGTCGCCGGTCTGTTGGAAGCCGACATCGAGCCCGGGTCCACCGTGGTGTGCCTG
ATTTCGGGCGGCAACAACGACGTGTCCCGTTACGGGGAGGTGTTGGAGCGCTCGCTGGTCCACCTGGGCCTCAAGCACTA
TTTCCTGGTCGACTTCCCGCAGGAGCCCGGTGCGCTGCGCCGGTTTCTCGACGACGTGCTCGGACCCAACGACGACATCA
CCTTGTTCGAGTACGTCAAGCGCAACAACCGGGAGACCGGTGAGGCGCTGGTGGGTATCGAGCTGGGATCGGCCGCGGAT
CTAGACGGTCTGCTGGCCCGGATGCGGGCGACCGACATTCACGTCGAGGCGTTGGAACCGGGGTCGCCGGCTTACCGCTA
TCTGCTGTAG

Upstream 100 bases:

>100_bases
TACCAGACCAAGACGGACCGCCAGATTCCGGTGTTCGTGCTGACCCCGGTGCGCGCGGGCGGCTAGCCATTGGGATAGGG
CGGCGTGGCACCATTGACCG

Downstream 100 bases:

>100_bases
CGAGGCGTCGGCGCGACCGTGCCGACAAACCTCGCATGTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATG
ACGAACTTGCCGCCGAGGTC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDE
ELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATL
VPPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTL
DHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCL
ISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAAD
LDGLLARMRATDIHVEALEPGSPAYRYLL

Sequences:

>Translated_429_residues
MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDE
ELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATL
VPPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTL
DHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCL
ISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAAD
LDGLLARMRATDIHVEALEPGSPAYRYLL
>Mature_428_residues
SAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDEE
LAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLV
PPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTLD
HVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCLI
SGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADL
DGLLARMRATDIHVEALEPGSPAYRYLL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family

Homologues:

Organism=Homo sapiens, GI11345492, Length=324, Percent_Identity=28.3950617283951, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33469958, Length=313, Percent_Identity=30.0319488817891, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI19923959, Length=327, Percent_Identity=31.1926605504587, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=38.4210526315789, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=36.2776025236593, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=31.7708333333333, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71991565, Length=346, Percent_Identity=32.0809248554913, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=321, Percent_Identity=26.4797507788162, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320930, Length=369, Percent_Identity=35.230352303523, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=31.974921630094, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21355833, Length=346, Percent_Identity=34.1040462427746, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=33.2, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THD1_MYCBO (P66898)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855237.1
- ProteinModelPortal:   P66898
- SMR:   P66898
- EnsemblBacteria:   EBMYCT00000016579
- GeneID:   1092464
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1585
- GeneTree:   EBGT00050000015763
- HOGENOM:   HBG714501
- OMA:   VDPFVDG
- ProtClustDB:   PRK08639
- BioCyc:   MBOV233413:MB1585-MONOMER
- BRENDA:   4.3.1.19
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820
- TIGRFAMs:   TIGR02079

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.3.1.19

Molecular weight: Translated: 45041; Mature: 44910

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQ
CCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEHHHHH
TVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQ
HHHHHHHCCEEEEEEEECCCHHHHHEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHH
KRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPPFDDLRTIAGQGTIAVEV
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCEEEEEE
LGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTL
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCH
DHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGA
HHHHHHHCCHHCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCH
LSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALR
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
RFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEP
HHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCEEEEEEECC
GSPAYRYLL
CCCCHHCCC
>Mature Secondary Structure 
SAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRLSAITGATVYLKREDLQ
CCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEHHHHH
TVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYACRCLGVHGRVYVPAKTPKQ
HHHHHHHCCEEEEEEEECCCHHHHHEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHH
KRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATLVPPFDDLRTIAGQGTIAVEV
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCEEEEEE
LGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVLGVEPAGAAAMMAALAAGEPVTL
HHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCH
DHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVDEGAVCTAMLDLYQNEGIIAEPAGA
HHHHHHHCCHHCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCH
LSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEVLERSLVHLGLKHYFLVDFPQEPGALR
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
RFLDDVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADLDGLLARMRATDIHVEALEP
HHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCEEEEEEECC
GSPAYRYLL
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972