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The map label for this gene is ubiE [C]

Identifier: 121637444

GI number: 121637444

Start: 1729994

End: 1731037

Strand: Direct

Name: ubiE [C]

Synonym: BCG_1575

Alternate gene names: 121637444

Gene position: 1729994-1731037 (Clockwise)

Preceding gene: 121637442

Following gene: 121637445

Centisome position: 39.55

GC content: 63.89

Gene sequence:

>1044_bases
ATGACGATAACCGCATTAACCGTGACGTTGCCGTTACTTTGGCGGCGTTTGACCACTGCGGGCGTCAAATACGCAGATCA
GGGGCATTTCGTGGGATCGGCTGGCGTGCCCGCAGCCGACGCTGGCGGGCGGGATGCGGCGTCCGAACAGATAGCTCGCT
GGACTCAAACTTGCACGGTCGTGCTGGTTTGCGGTCACGGTCCGGCAAAGTGGGCATTTCGGTCCTGGTGCACCTCGCGG
TCGTGCGACACTCTCCCCGTGGCTCTTAGGTATCGCCTGCAGTCCAATCCGTTGGTCGGCAAGCTCACGACCAAGTACTT
CTTGCCGCTTGGCACTCGCCAGGTCGGCGATCACGTGGTGTTTTTCAACTTCGGCTACGAGGAGGATCCGCCGATGGCGT
TGCCGCTGTCGGAGTCCGACGAGCCCAATCGGTATTGCATCCAGCTCTACCACCAGACGGCCAGTCAGGTGGACCTCACC
GGCAAGGAGGTGCTAGAGGTCAGTTGTGGCGCCGGTGGCGGGGCCTCCTACATCGCCCGCAACCTAGGTCCGGCCTCCTA
CACGGGGCTGGACTTGAATCCGGCCAGCATCGACCTCTGCCGGGCAAAGCACCGGCTGCCCGGCCTGCAGTTCGTGCAGG
GCGACGCGCAGAACCTGCCTTTCCCCGACGAATCCTTCGATGCGGTGGTCAATGTCGAAGCCTCGCACCAGTACCCCGAC
TTTCGCGGCTTCTTGGCCGAAGTGGCGCGCGTGCTTCGCCCGGGCGGACACTTCCTCTACACCGATTCCCGTCGAAATCC
CGTCGTCGCCGAATGGGAGGCGGCGTTGGCCGATGCTCCGCTGCGCACGATTTCGCAGCGGGACATCGGCGCGCAGGCCA
AGCGTGGGTTGGATGCGAACACGGCGCGTTCGCAAGAGGCCATCGGCCGCCGCGCACCCGTATTGCTGGCCGGCTTGACC
CGCTGTGCGGTGCGTGTGCTGGACTGGGATCTACGTCGCGGCGGCGGGTTCAGCTATCGGATCTACTTGTTCGCCAAGGA
TTGA

Upstream 100 bases:

>100_bases
CACGAAGTTGCCGATACGGTCGAACAGTCCCCCGGCTTTGGCCTCGTCATGCCTTGCCACCCGATAACCGTACAAGCCTG
GCAATCGGTGGCGTGGGGAA

Downstream 100 bases:

>100_bases
TTCGGCGAGACCACACCCATGAAAAACTCATGAAATTTGTCGTGGCCAGCTATGGGACTCGCGGCGACATCGAGCCCTGC
GCAGCGGTCGGCCTGGAGCT

Product: putative methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSR
SCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLT
GKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
FRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLT
RCAVRVLDWDLRRGGGFSYRIYLFAKD

Sequences:

>Translated_347_residues
MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSR
SCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLT
GKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
FRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLT
RCAVRVLDWDLRRGGGFSYRIYLFAKD
>Mature_346_residues
TITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSRS
CDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLTG
KEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDF
RGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTR
CAVRVLDWDLRRGGGFSYRIYLFAKD

Specific function: Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17540496, Length=128, Percent_Identity=39.0625, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 37915; Mature: 37784

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQIARWTQTCTV
CEEEEHHHHHHHHHHHHHHHCCEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCEEEE
VLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVV
EEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEECCEEEECCCCCCCCCEEE
FFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGASYIAR
EEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCHHHHHH
NLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCH
FRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDAN
HHHHHHHHHHHHCCCCCEEEECCCCCCEEEHHHHHHHCCCHHHHHHHCCCHHHHCCCCCC
TARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRGGGFSYRIYLFAKD
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
>Mature Secondary Structure 
TITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQIARWTQTCTV
EEEEHHHHHHHHHHHHHHHCCEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCEEEE
VLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVV
EEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEECCEEEECCCCCCCCCEEE
FFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGASYIAR
EEECCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCCCHHHHHH
NLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPD
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCH
FRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKRGLDAN
HHHHHHHHHHHHCCCCCEEEECCCCCCEEEHHHHHHHCCCHHHHHHHCCCHHHHCCCCCC
TARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRGGGFSYRIYLFAKD
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]