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The map label for this gene is hemH

Identifier: 121637416

GI number: 121637416

Start: 1700089

End: 1701123

Strand: Direct

Name: hemH

Synonym: BCG_1547

Alternate gene names: 121637416

Gene position: 1700089-1701123 (Clockwise)

Preceding gene: 121637415

Following gene: 121637418

Centisome position: 38.86

GC content: 66.09

Gene sequence:

>1035_bases
ATGCAATTTGATGCCGTCCTGCTGCTGTCGTTCGGCGGACCGGAAGGGCCCGAGCAGGTGCGGCCGTTCCTGGAGAACGT
TACCCGGGGCCGCGGTGTGCCTGCCGAACGGTTGGACGCGGTGGCCGAGCACTACCTGCATTTCGGTGGGGTATCACCGA
TCAATGGCATTAATCGCACACTGATCGCGGAGCTGGAGGCGCAGCAAGAACTGCCGGTGTACTTCGGTAACCGCAACTGG
GAGCCGTATGTAGAAGATGCCGTTACGGCCATGCGCGACAACGGTGTCCGGCGTGCAGCGGTCTTTGCGACATCTGCGTG
GAGCGGTTACTCGAGCTGCACACAGTACGTGGAGGACATCGCGCGGGCCCGCCGCGCGGCCGGGCGCGACGCGCCTGAAC
TGGTAAAACTGCGGCCCTACTTCGACCATCCGCTGTTCGTCGAGATGTTCGCCGACGCCATCACCGCGGCCGCCGCAACC
GTGCGCGGTGATGCCCGGCTGGTGTTCACCGCGCATTCGATCCCGACGGCCGCCGACCGCCGCTGTGGCCCCAACCTCTA
CAGCCGCCAAGTCGCCTACGCCACAAGGCTGGTCGCGGCCGCTGCCGGATACTGCGACTTTGACCTGGCCTGGCAGTCGA
GATCGGGCCCGCCGCAGGTGCCCTGGCTGGAGCCAGACGTTACCGACCAGCTCACCGGTCTGGCTGGGGCCGGCATCAAC
GCGGTGATCGTGTGTCCCATTGGATTCGTCGCCGACCATATCGAGGTGGTGTGGGATCTCGACCACGAGTTGCGATTACA
AGCCGAGGCAGCGGGCATCGCGTACGCCCGGGCCAGCACCCCCAATGCCGACCCGCGGTTCGCTCGACTAGCCAGAGGTT
TGATCGACGAACTCCGTTACGGCCGTATACCTGCGCGGGTGAGTGGCCCCGATCCGGTGCCGGGCTGTCTGTCCAGCATC
AACGGCCAGCCATGCCGTCCGCCGCACTGCGTGGCTAGCGTCAGTCCGGCCAGGCCGAGTGCAGGATCGCCGTGA

Upstream 100 bases:

>100_bases
CCAAGACGGTGTGCGCGCTGCTGTCTGACTGGCTGCCGGCGACCACGGGTGACATCATCTACGCCGACGGCGGCGCGCAC
ACCCAATTGCTCTAGAACGC

Downstream 100 bases:

>100_bases
CCGCGGACATCCGGGCCGAGCGGCACCACGGCGGTCAACGGTCTCAACGCATCGGTGGCACGCTGAGCGTCCGACAACGA
CTGCGTTCCGATCGGCAATC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNW
EPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAAT
VRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN
AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSI
NGQPCRPPHCVASVSPARPSAGSP

Sequences:

>Translated_344_residues
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNW
EPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAAT
VRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN
AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSI
NGQPCRPPHCVASVSPARPSAGSP
>Mature_344_residues
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNW
EPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAAT
VRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN
AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSI
NGQPCRPPHCVASVSPARPSAGSP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=279, Percent_Identity=27.2401433691756, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI60499021, Length=279, Percent_Identity=27.2401433691756, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17864156, Length=315, Percent_Identity=27.9365079365079, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552018, Length=152, Percent_Identity=35.5263157894737, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_MYCBO (P0A577)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855173.1
- ProteinModelPortal:   P0A577
- SMR:   P0A577
- EnsemblBacteria:   EBMYCT00000015512
- GeneID:   1092378
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1521
- GeneTree:   EBGT00050000016242
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- BioCyc:   MBOV233413:MB1521-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 37144; Mature: 37144

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRT
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
LIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDI
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRGDARLVFTAHSIPTAADR
HHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHC
RCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCC
AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRY
EEEEECHHHHHHHHHHEECCCHHHEEEHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
GRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP
CCCCCCCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRT
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
LIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDI
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRGDARLVFTAHSIPTAADR
HHHHHHCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHC
RCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCC
AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRY
EEEEECHHHHHHHHHHEECCCHHHEEEHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
GRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP
CCCCCCCCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972