Click here to switch to the map view.

The map label for this gene is csd

Identifier: 121637394

GI number: 121637394

Start: 1676590

End: 1677843

Strand: Direct

Name: csd

Synonym: BCG_1525

Alternate gene names: 121637394

Gene position: 1676590-1677843 (Clockwise)

Preceding gene: 121637393

Following gene: 121637395

Centisome position: 38.33

GC content: 67.86

Gene sequence:

>1254_bases
ATGACGGCCTCGGTGAACTCGCTCGATCTGGCGGCGATTCGCGCCGATTTCCCCATCCTCAAGCGCATCATGCGGGGTGG
AAACCCGTTGGCGTATTTGGACTCCGGCGCCACCTCACAACGCCCGCTGCAGGTCCTCGACGCCGAGCGCGAGTTCCTGA
CCGCGTCCAACGGCGCGGTCCATCGTGGCGCGCACCAGCTGATGGAGGAGGCGACCGACGCCTACGAGCAGGGCCGCGCG
GACATCGCGTTATTCGTCGGCGCCGACACGGACGAGCTGGTGTTCACCAAAAATGCCACCGAGGCGCTCAACCTGGTGTC
ATATGTGCTGGGGGACAGCCGTTTCGAGCGTGCCGTCGGCCCCGGCGACGTGATCGTCACCACCGAGCTGGAGCATCACG
CCAACCTGATCCCGTGGCAGGAGCTGGCCCGGCGCACCGGGGCCACATTGCGCTGGTACGGGGTGACTGACGACGGGCGC
ATCGACCTGGACTCGCTGTATCTGGACGACCGTGTCAAAGTCGTTGCGTTCACCCATCATTCCAATGTGACCGGGGTGCT
GACACCGGTGAGCGAGCTGGTCTCCCGCGCCCACCAGTCGGGTGCGCTGACCGTGCTGGACGCCTGCCAGTCGGTGCCGC
ACCAGCCGGTTGACCTGCACGAACTCGGCGTCGACTTCGCCGCGTTTTCCGGACATAAAATGCTGGGCCCCAACGGAATC
GGTGTGCTGTACGGCCGCCGTGAGCTGCTAGCGCAGATGCCCCCATTTCTCACCGGCGGTTCGATGATCGAAACGGTGAC
CATGGAAGGCGCCACCTACGCGCCGGCGCCGCAACGGTTCGAGGCCGGTACCCCGATGACCTCCCAGGTGGTCGGGTTGG
CCGCCGCGGCCCGCTATCTCGGCGCGATCGGCATGGCCGCGGTGGAGGCCCACGAGCGGGAGCTGGTAGCCGCGGCCATC
GAAGGCCTGTCCGGCATCGACGGTGTGCGGATCCTTGGCCCGACGTCGATGCGGGACCGAGGGTCGCCGGTGGCGTTCGT
CGTCGAGGGCGTGCACGCGCACGACGTGGGTCAGGTACTCGACGACGGCGGCGTGGCGGTGCGGGTCGGGCACCACTGCG
CGCTGCCGCTGCACCGCAGGTTCGGTCTGGCCGCCACCGCGCGGGCGTCGTTCGCGGTGTACAACACCGCAGACGAGGTG
GACCGCTTGGTGGCCGGCGTGCGGCGATCCCGGCATTTCTTTGGAAGAGCGTGA

Upstream 100 bases:

>100_bases
GGTTCGGAGCTCGCCGACGAACTCGACCAGAACGGCTACGTGCGTTTCTCCCCCGCAAGCGGGCGGTACCCCCACCAACC
CGCGCCAACCGGAGCCTGAC

Downstream 100 bases:

>100_bases
CGTTGCGTCTGGAGCAGATCTATCAGGACGTGATCCTCGATCACTACAAGCATCCGCAGCATCGGGGGCTGCGGGAGCCG
TTCGGCGCCCAGGTGTATCA

Product: putative cysteine desulfurase csd

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRA
DIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGR
IDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGI
GVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAI
EGLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEV
DRLVAGVRRSRHFFGRA

Sequences:

>Translated_417_residues
MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRA
DIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGR
IDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGI
GVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAI
EGLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEV
DRLVAGVRRSRHFFGRA
>Mature_416_residues
TASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRAD
IALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRI
DLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGIG
VLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIE
GLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEVD
RLVAGVRRSRHFFGRA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=268, Percent_Identity=29.4776119402985, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156713448, Length=312, Percent_Identity=25.3205128205128, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=45.4545454545455, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789175, Length=410, Percent_Identity=37.8048780487805, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI48994898, Length=394, Percent_Identity=28.4263959390863, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=305, Percent_Identity=26.5573770491803, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=349, Percent_Identity=24.3553008595989, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=242, Percent_Identity=32.6446280991736, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129463, Length=236, Percent_Identity=33.0508474576271, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD_MYCBO (P63517)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855151.1
- ProteinModelPortal:   P63517
- SMR:   P63517
- EnsemblBacteria:   EBMYCT00000017291
- GeneID:   1092356
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1499
- GeneTree:   EBGT00050000015336
- HOGENOM:   HBG635316
- OMA:   AMPPFIT
- ProtClustDB:   CLSK791179
- BioCyc:   MBOV233413:MB1499-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 44597; Mature: 44466

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 373-373

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAV
CCCCCCCCCHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHEECCCCCH
HRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVG
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHCCHHHHHCCC
PGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHH
CCCEEEEEEHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEEHHHEEECCCEEEEEEEEC
SNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGI
CCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHCCCCEECCCCEEECCCCC
GVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYL
EEEECHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHHH
DDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEVDRLVAGVRRSRHFFGRA
CCCCEEEEECCEECCCHHHHCCCCHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAV
CCCCCCCCHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHEECCCCCH
HRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVG
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHCCHHHHHCCC
PGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHH
CCCEEEEEEHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEEHHHEEECCCEEEEEEEEC
SNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGI
CCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHCCCCEECCCCEEECCCCC
GVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYL
EEEECHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHHHHH
DDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEVDRLVAGVRRSRHFFGRA
CCCCEEEEECCEECCCHHHHCCCCHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972