Click here to switch to the map view.

The map label for this gene is PE16 [H]

Identifier: 121637360

GI number: 121637360

Start: 1631174

End: 1632760

Strand: Direct

Name: PE16 [H]

Synonym: BCG_1491

Alternate gene names: 121637360

Gene position: 1631174-1632760 (Clockwise)

Preceding gene: 121637359

Following gene: 121637361

Centisome position: 37.29

GC content: 64.02

Gene sequence:

>1587_bases
ATGTCGTTCGTTTTCGCGGTGCCAGAGATGGTGGCGGCAACCGCTTCCGATTTGGCCAGCCTCGGAGCGGCGCTGAGCGA
GGCCACCGCGGCGGCGGCTATCCCCACCACACAAGTACTGGCCGCGGCCGCCGATGAGGTGTCGGCGGCCATCGCGGAGT
TGTTCGGTGCGCACGGCCAAGAATTTCAAGCGCTCAGCGCCCAGGCATCGGCGTTTCATGACCGGTTCGTGCGGGCCCTA
AGCGCCGCAGCGGGCTGGTATGTCGACGCCGAGGCCGCCAACGCCGCGCTGGTGGACACCGCGGCCACCGGCGCGTCGGA
GTTGGGGTCAGGTGGGCGCACGGCGCTGATTCTGGGCTCCACCGGAACCCCGCGACCGCCCTTCGACTACATGCAGCAGG
TCTACGACCGCTACATCGCACCCCACTACTTGGGCTATGCGTTTTCCGGCCTGTACACGCCCGCGCAGTTTCAGCCGTGG
ACCGGCATCCCCAGCCTGACCTACGACCAATCGGTCGCCGAAGGCGCCGGCTATCTTCACACCGCGATCATGCAGCAAGT
CGCGGCCGGCAATGACGTTGTGGTGTTGGGTTTCTCGCAGGGCGCGTCGGTCGCCACCCTGGAAATGCGCCATCTGGCAA
GCCTGCCGGCCGGCGTCGCGCCGAGTCCGGATCAGCTCTCGTTCGTATTGCTGGGCAACCCCAACAACCCAAACGGGGGC
ATCCTCGCCCGGTTTCCGGGTCTGTACCTGCAGTCGCTCGGCCTGACGTTCAACGGTGCGACCCCGGACACCGACTACGC
GACCACCATTTACACGACCCAATACGACGGCTTTGCCGACTTCCCGAAGTACCCGCTCAACATCCTGGCGGACGTCAACG
CGCTGCTGGGTATTTACTATTCGCACAGCTTGTATTACGGGCTCACGCCCGAGCAGGTCGCTTCGGGTATCGTCCTGCCG
GTGTCTTCGCCGGACACCAACACCACCTATATTCTGCTTCCCAACGAGGATCTGCCGCTGCTGCAGCCGCTGCGCGGTAT
TGTGCCCGAGCCGCTGCTGGATCTCATCGAGCCAGACCTGCGCGCGATCATCGAATTGGGTTATGACCGAACCGGATACG
CCGATGTTCCGACCCCGGCCGCACTGTTCCCGGTGCACATCGACCCGATCGCAGTCCCGCCCCAGATAGGCGCTGCGATC
GGTGGTCCGCTCACCGCCCTGGATGGCTTGCTCGACACCGTGATCAACGATCAACTCAATCCCGTCGTAACGTCGGGCAT
CTATCAGGCCGGTGCTGAGCTGTCGGTGGCCGCGGCCGGCTACGGTGCTCCCGCAGGCGTCACCAATGCCATTTTTATTG
GGCAGCAAGTGTTGCCGATTTTGGTGGAAGGCCCCGGTGCCTTGGTGACGGCCGACACCCATTACCTGGTCGATGCGATT
CAGGATTTGGCCGCCGGTGACCTCAGCGGGTTCAACCAAAACCTGCAACTCATCCCGGCTACCAACATAGCCCTGCTGGT
CTTCGCGGCCGGAATTCCCGCTGTGGCGGCCGTCGCCATCCTTACCGGTCAGGATTTTCCGGTATAG

Upstream 100 bases:

>100_bases
TCCGCCAGAGGGGGGCGGACCCGGCGTATACCCAATTCGCGTCGCTCGGTTCTAGTTGGGCGCTATCATCCGTTGCCACG
GGGTTGGTCGGAAGGTCGGT

Downstream 100 bases:

>100_bases
GCCCCCGGCCCCCGCTGTACCGAGCTCGGCCAGTGAAGAACAACCCCAGGCGTTGCCAGTCCGAATAGATTGTATTCGTC
AGCCGGCGCAGGACAGGAAG

Product: PE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRAL
SAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPW
TGIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
ILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLP
VSSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAI
GGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAI
QDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV

Sequences:

>Translated_528_residues
MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRAL
SAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPW
TGIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
ILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLP
VSSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAI
GGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAI
QDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
>Mature_527_residues
SFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALS
AAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWT
GIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGGI
LARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPV
SSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAIG
GPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQ
DLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV

Specific function: Elicits a high humoral and a low T cell response. Could be involved in directing the host toward development of a more humoral type of immune response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002989
- InterPro:   IPR013228
- InterPro:   IPR000030 [H]

Pfam domain/function: PF08237 PE-PPE; PF01469 Pentapeptide_2; PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 54584; Mature: 54453

Theoretical pI: Translated: 3.83; Mature: 3.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCHHHHCCCCCEEEEECC
TGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWTGIPSLTYDQSVAEGAGYLH
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
TAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
HHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
ILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYY
EEEECCCHHHHHCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDL
HCCEEECCCHHHHHCCEEEEECCCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHCHHH
RAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTALDGLLDTVINDQLN
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCC
PVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAI
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHH
QDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
HHHHHCCCCCCCCCEEEEECCCEEEHHHHCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQ
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
EFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCHHHHCCCCCEEEEECC
TGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWTGIPSLTYDQSVAEGAGYLH
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
TAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG
HHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
ILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYY
EEEECCCHHHHHCCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDL
HCCEEECCCHHHHHCCEEEEECCCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHCHHH
RAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTALDGLLDTVINDQLN
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCC
PVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAI
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHH
QDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
HHHHHCCCCCCCCCEEEEECCCEEEHHHHCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]