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The map label for this gene is ribC

Identifier: 121637342

GI number: 121637342

Start: 1613355

End: 1613960

Strand: Direct

Name: ribC

Synonym: BCG_1473

Alternate gene names: 121637342

Gene position: 1613355-1613960 (Clockwise)

Preceding gene: 121637339

Following gene: 121637343

Centisome position: 36.88

GC content: 65.51

Gene sequence:

>606_bases
ATGTTCACCGGAATTGTTGAGGAACGCGGAGAAGTGACCGGGCGTGAGGCCCTGGTCGATGCGGCGCGGCTGACCATCCG
CGGTCCGATGGTTACCGCCGACGCCGGCCACGGCGACTCGATCGCTGTCAACGGCGTGTGTCTGACGGTCGTCGATGTAT
TGCCCGACGGCCAATTCACCGCCGACGTGATGGCCGAGACACTGAACCGGTCCAACCTGGGTGAGCTACGGCCCGGCAGC
CGGGTGAACCTGGAACGCGCCGCGGCGCTGGGCAGCCGGCTCGGCGGGCACATCGTGCAGGGACATGTGGACGCCACCGG
TGAAATCGTGGCTCGTTGTCCCTCCGAGCACTGGGAAGTGGTGCGCATCGAGATGCCGGCTTCGGTGGCTCGCTATGTCG
TCGAAAAGGGCTCGATCACCGTCGACGGGATTTCTCTGACGGTCTCCGGGCTCGGCGCCGAACAGCGGGACTGGTTTGAG
GTCTCGCTGATCCCGACGACCCGGGAGCTGACCACGCTGGGGTCCGCTGCGGTGGGAACCCGGGTGAACCTCGAAGTCGA
CGTAGTCGCAAAGTATGTTGAGCGGTTAATGCGGAGCGCCGGCTGA

Upstream 100 bases:

>100_bases
GTCTGGGGGTCCGCATACCCTGCATCGTAGAGGGTGTCTGTGAGTTGGCCGGTCGGCGAGTGGGGTGCGGGTCCGCGGGA
TTGCTGCCTAACCTGGTGCG

Downstream 100 bases:

>100_bases
CATCGCTCGCCGAGGGAGGGAGCCCCATGTCTTGCATTCCGGACGAGATCGATACGCCCGACGTGCTGATCGACCGCGAC
ATCCTTGACCGCAACATCGG

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGS
RVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFE
VSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG

Sequences:

>Translated_201_residues
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGS
RVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFE
VSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG
>Mature_201_residues
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGS
RVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFE
VSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats

Homologues:

Organism=Escherichia coli, GI1787952, Length=203, Percent_Identity=36.9458128078818, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319733, Length=204, Percent_Identity=38.2352941176471, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISA_MYCBO (P65328)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_855099.1
- ProteinModelPortal:   P65328
- SMR:   P65328
- EnsemblBacteria:   EBMYCT00000015090
- GeneID:   1092304
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1447
- GeneTree:   EBGT00050000017347
- HOGENOM:   HBG289809
- OMA:   PVNLEVD
- ProtClustDB:   PRK09289
- BioCyc:   MBOV233413:MB1447-MONOMER
- BRENDA:   2.5.1.9
- InterPro:   IPR001783
- InterPro:   IPR017938
- PANTHER:   PTHR21098
- PIRSF:   PIRSF000498
- TIGRFAMs:   TIGR00187

Pfam domain/function: PF00677 Lum_binding; SSF63380 Riboflavin_synthase_like_b-brl

EC number: =2.5.1.9

Molecular weight: Translated: 21321; Mature: 21321

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS51177 LUMAZINE_BIND; PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFT
CCCCCCCCCCCCCHHHHHHHHHHEEEECCEEEECCCCCCEEEECCEEEEEEECCCCCCCH
ADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHEECCCCCCEEE
VRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSLIPTTRELTTLGSAAVGT
EEEECCHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCEEEEEEECCCHHHHHCCCHHCCC
RVNLEVDVVAKYVERLMRSAG
EEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFT
CCCCCCCCCCCCCHHHHHHHHHHEEEECCEEEECCCCCCEEEECCEEEEEEECCCCCCCH
ADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHEECCCCCCEEE
VRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSLIPTTRELTTLGSAAVGT
EEEECCHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCEEEEEEECCCHHHHHCCCHHCCC
RVNLEVDVVAKYVERLMRSAG
EEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972