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The map label for this gene is echA11 [H]

Identifier: 121637074

GI number: 121637074

Start: 1299618

End: 1300424

Strand: Reverse

Name: echA11 [H]

Synonym: BCG_1203c

Alternate gene names: 121637074

Gene position: 1300424-1299618 (Counterclockwise)

Preceding gene: 121637075

Following gene: 121637072

Centisome position: 29.73

GC content: 65.68

Gene sequence:

>807_bases
ATGCCAGATTCCGGGATTGCCGCATTAACGCCGGTCACAGGCCTCAACGTCACCCTGACCGACAGAGTGTTGTCGGTGCG
CATCAACCGCCCTAGCAGTCTCAACTCGCTGACCGTGCCAATCCTGACGGGGATCGCCGACACGCTGGAGCGCGCGGCGG
CCGATCCCGTGGTCAAGGTGGTGCGCCTAGGCGGGGTGGGCCGCGGTTTCAGCTCCGGAGTGTCTATGTCTGTGGACGAT
GTGTGGGGCGGAGGGCCGCCGACCGCCATCGTCGAAGAGGCCAACCGCGCAGTACGCGCCGTGGCCGCGCTACCGCACCC
GGTTGTAGCTGTCGTTCAAGGACCAGCGGTCGGCGTCGCTGTCTCGCTAGCGCTGGCGTGTGACTTCATATTGGCTTCTG
ATAGTGCATTTTTCATGCTCGCCAACACCAAGGTAGCGTTGATGCCCGACGGCGGCGCATCGGCGTTAGTCGCCGCGGCC
ACCGGCCGGATCCGGGCGATGCGGCTGGCGCTGCTGGCCGAGCAACTGCCGGCCCGCGAGGCACTGGCCTGGGGCCTGAT
CAGCGCGGTATATCCGGACAGCGACTTCGAGGCCGAGGTGGACAAGGTGATTTCACGGTTGCTGGCCGGCCCGGCGCTGG
CGTTCGCCCAGGCCAAAAACGCCATCAATGCAGCCGCCCTCACCGAATTGGAACCCACGTTCGCGCGCGAATTGGATGGA
CAGGAAGTCCTGCTGCGAACACACGACTTCGCCGAGGGCGCAGCGGCGTTCCTGCAACGCCGCACCCCCAACTTCACCGG
TTCCTGA

Upstream 100 bases:

>100_bases
ATGCCCGTGTACTCACCGATTACTCCAACTGCTGGTTGGGCATGTTTGCGGAGCATCATTAACCACTCTGTGTAGCTGGC
CCTCATTTAGGATGCTGCAC

Downstream 100 bases:

>100_bases
ACGCGCGTCAGACCGCGAACAGCGGGGGCAGCGCGAACACCATGATCAGGCCCCACACGAAGTGGGTCAAGATCGGTGCC
AGCACTCCACCGCTGGCCCG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDD
VWGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAA
TGRIRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDG
QEVLLRTHDFAEGAAAFLQRRTPNFTGS

Sequences:

>Translated_268_residues
MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDD
VWGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAA
TGRIRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDG
QEVLLRTHDFAEGAAAFLQRRTPNFTGS
>Mature_267_residues
PDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDDV
WGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAAT
GRIRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDGQ
EVLLRTHDFAEGAAAFLQRRTPNFTGS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=256, Percent_Identity=28.515625, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45643119, Length=254, Percent_Identity=28.3464566929134, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI260275230, Length=254, Percent_Identity=28.3464566929134, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=25.4032258064516, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4757968, Length=236, Percent_Identity=27.1186440677966, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI49355787, Length=236, Percent_Identity=27.1186440677966, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4757966, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI51538581, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221136756, Length=245, Percent_Identity=27.7551020408163, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221136753, Length=245, Percent_Identity=27.7551020408163, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI25453481, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI51538573, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221307494, Length=245, Percent_Identity=27.7551020408163, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI70995211, Length=186, Percent_Identity=27.4193548387097, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI31542718, Length=261, Percent_Identity=24.5210727969349, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI116235487, Length=213, Percent_Identity=27.2300469483568, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787660, Length=250, Percent_Identity=35.2, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787659, Length=261, Percent_Identity=31.0344827586207, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788597, Length=252, Percent_Identity=29.7619047619048, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082183, Length=263, Percent_Identity=23.9543726235741, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17535521, Length=207, Percent_Identity=28.5024154589372, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=240, Percent_Identity=27.9166666666667, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=25.9842519685039, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=193, Percent_Identity=30.5699481865285, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=24.8091603053435, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=209, Percent_Identity=31.1004784688995, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=261, Percent_Identity=26.4367816091954, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=26.5560165975104, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=26.5560165975104, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24654903, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653139, Length=246, Percent_Identity=26.4227642276423, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19920382, Length=263, Percent_Identity=24.3346007604563, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27616; Mature: 27485

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKV
CCCCCCEEECCCCCCEEEEECEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
VRLGGVGRGFSSGVSMSVDDVWGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVA
HHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
VSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAATGRIRAMRLALLAEQLPARE
HHHHHHHHHHEECCCEEEEEECCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCHHH
ALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
QEVLLRTHDFAEGAAAFLQRRTPNFTGS
CEEEEECCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKV
CCCCCEEECCCCCCEEEEECEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
VRLGGVGRGFSSGVSMSVDDVWGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVA
HHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
VSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAATGRIRAMRLALLAEQLPARE
HHHHHHHHHHEECCCEEEEEECCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCHHH
ALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
QEVLLRTHDFAEGAAAFLQRRTPNFTGS
CEEEEECCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]